Melvyn P. Heyes

Elevated cerebrospinal fluid quinolinic acid levels are associated with region-specific cerebral volume loss in HIV infection (2001)

Heyes, Melvyn P., Ellis, Ronald J., Ryan, Lee, Childers, Meredith E., Grant, Igor, Wolfson, Tanya, ...

Neuronal injury, dendritic loss and brain atrophy are frequent complications of infection with human immunodeficiency virus (HIV) type 1. Activated brain macrophages and microglia can release...

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Gunther, Erik C., Stone, David J., Gerwien, Robert W., Bento, Patricia, Heyes, Melvyn P.

Assays of drug action typically evaluate biochemical activity. However, accurately matching therapeutic efficacy with biochemical activity is a challenge. High-content cellular assays seek to bridge...

Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

Gunther, Erik C., Stone, David J., Gerwien, Robert W., Bento, Patricia, Heyes, Melvyn P.

Assays of drug action typically evaluate biochemical activity. However, accurately matching therapeutic efficacy with biochemical activity is a challenge. High-content cellular assays seek to bridge...