Merab Kokaia

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2

Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...

Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...

Long-term potentiation and dual-component quantal signaling in the dentate gyrus

Min, Ming-Yuan, Asztely, Fredrik, Kokaia, Merab, Kullmann, Dimitri M.

Long-term potentiation (LTP) of excitatory transmission is an important candidate cellular mechanism for the storage of memories in the mammalian brain. The subcellular phenomena that underlie the...

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

Bengzon, Johan, Kokaia, Zaal, Elmér, Eskil, Nanobashvili, Avtandil, Kokaia, Merab, Lindvall, Olle

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ...

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...

The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Englund, Ulrica, Björklund, Anders, Wictorin, Klas, Lindvall, Olle, Kokaia, Merab

In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation after transplantation to the developing or adult brain, and display morphologies and markers characteristic...

Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor α2

Nanobashvili, Avtandil, Airaksinen, Matti S., Kokaia, Merab, Rossi, Jari, Asztély, Fredrik, Olofsdotter, Klara, ...

Seizure activity regulates gene expression for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), and their receptor components, the transmembrane c-Ret tyrosine kinase and the...

Long-term potentiation and dual-component quantal signaling in the dentate gyrus

Min, Ming-Yuan, Asztely, Fredrik, Kokaia, Merab, Kullmann, Dimitri M.

Long-term potentiation (LTP) of excitatory transmission is an important candidate cellular mechanism for the storage of memories in the mammalian brain. The subcellular phenomena that underlie the...

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

Bengzon, Johan, Kokaia, Zaal, Elmér, Eskil, Nanobashvili, Avtandil, Kokaia, Merab, Lindvall, Olle

Neuronal apoptosis was observed in the rat dentate gyrus in two experimental models of human limbic epilepsy. Five hours after one hippocampal kindling stimulation, a marked increase of in situ...

Suppressed kindling epileptogenesis in mice with ectopic overexpression of galanin

Kokaia, Merab, Holmberg, Kristina, Nanobashvili, Avtandil, Xu, Zhi-Qing D., Kokaia, Zaal, Lendahl, Urban, ...

The neuropeptide galanin has been shown to suppress epileptic seizures. In cortical and hippocampal areas, galanin is normally mainly expressed in noradrenergic afferents. We have generated a mouse...

Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry

Englund, Ulrica, Björklund, Anders, Wictorin, Klas, Lindvall, Olle, Kokaia, Merab

In vitro expanded neural stem/progenitor cells can undergo region-specific differentiation after transplantation to the developing or adult brain, and display morphologies and markers characteristic...

Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice

Parish, Clare L., Castelo-Branco, Gonçalo, Rawal, Nina, Tonnesen, Jan, Sorensen, Andreas Toft, Salto, Carmen, ...

Dopamine (DA) cell replacement therapy in Parkinson disease (PD) can be achieved using human fetal mesencephalic tissue; however, limited tissue availability has hindered further developments....