Young, Matthew R., Li, Jian-Jian, Rincón, Mercedes, Flavell, Richard A., Sathyanarayana, B. K., Hunziker, Rosemarie, ...
Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced...
Requirement for Transcription Factor NFAT in Interleukin-2 Expression
Chow, Chi-Wing, Rincón, Mercedes, Davis, Roger J.
The nuclear factor of activated T cells (NFAT) transcription factor is implicated in expression of the cytokine interleukin-2 (IL-2). Binding sites for NFAT are located in the IL-2 promoter....
Merritt, Chris, Enslen, Hervé, Diehl, Nicole, Conze, Dietrich, Davis, Roger J., Rincón, Mercedes
CD4+ and CD8+ T cells play specific roles during an immune response. Different molecular mechanisms could regulate the proliferation, death, and effector functions of these two subsets of T cells....
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Farley, Nicholas, Pedraza-Alva, Gustavo, Serrano-Gomez, Diego, Nagaleekar, Viswas, Aronshtam, Alexander, Krahl, Troy, ...
The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated by a variety of stress stimuli such as UV radiation and osmotic stress. The regulation and role of this pathway in...
Young, Matthew R., Li, Jian-Jian, Rincón, Mercedes, Flavell, Richard A., Sathyanarayana, B. K., Hunziker, Rosemarie, ...
Activator protein-1 (AP-1) is a transcription factor that consists of either a Jun-Jun homodimer or a Jun-Fos heterodimer. Transactivation of AP-1 is required for tumor promoter-induced...
Requirement for Transcription Factor NFAT in Interleukin-2 Expression
Chow, Chi-Wing, Rincón, Mercedes, Davis, Roger J.
The nuclear factor of activated T cells (NFAT) transcription factor is implicated in expression of the cytokine interleukin-2 (IL-2). Binding sites for NFAT are located in the IL-2 promoter....
Merritt, Chris, Enslen, Hervé, Diehl, Nicole, Conze, Dietrich, Davis, Roger J., Rincón, Mercedes
CD4+ and CD8+ T cells play specific roles during an immune response. Different molecular mechanisms could regulate the proliferation, death, and effector functions of these two subsets of T cells....
Jaeschke, Anja, Rincón, Mercedes, Doran, Beth, Reilly, Judith, Neuberg, Donna, Greiner, Dale L., ...
The c-Jun NH2-terminal kinase isoform (JNK) 1 is implicated in type 2 diabetes. However, a potential role for the JNK2 protein kinase in diabetes has not been established. Here, we demonstrate that...
Farley, Nicholas, Pedraza-Alva, Gustavo, Serrano-Gomez, Diego, Nagaleekar, Viswas, Aronshtam, Alexander, Krahl, Troy, ...
The p38 mitogen-activated protein kinase (MAPK) signaling pathway can be activated by a variety of stress stimuli such as UV radiation and osmotic stress. The regulation and role of this pathway in...
Hedrick, Michael N., Olson, Chris M., Conze, Dietrich B., Bates, Tonya C., Rincón, Mercedes, Anguita, Juan
Infection with Borrelia burgdorferi, the causative agent of Lyme disease, results in a Th1 response and proinflammatory cytokine production. Mice deficient for MKK3, an upstream activator of p38...
Pedraza-Alva, Gustavo, Koulnis, Miroslav, Charland, Colette, Thornton, Tina, Clements, James L, Schlissel, Mark S, ...
Delay of cell cycle progression in response to double-strand DNA breaks (DSBs) is critical to allow time for DNA repair and prevent cellular transformation. Here, we show that the p38...
Hatle, Ketki M., Neveu, Wendy, Dienz, Oliver, Rymarchyk, Stacia, Barrantes, Ramiro, Hale, Sarah, ...
Methylation-controlled J protein (MCJ) is a newly identified member of the DnaJ family of cochaperones. Hypermethylation-mediated transcriptional silencing of the MCJ gene has been associated with...
c-Jun N-Terminal Kinase 1 Is Required for Toll-Like Receptor 1 Gene Expression in Macrophages▿
Izadi, Hooman, Motameni, Amirreza T., Bates, Tonya C., Olivera, Elias R., Villar-Suarez, Vega, Joshi, Ila, ...
The regulation of innate immune responses to pathogens occurs through the interaction of Toll-like receptors (TLRs) with pathogen-associated molecular patterns and the activation of several signaling...
Induction of NFATc2 Expression by Interleukin 6 Promotes T Helper Type 2 Differentiation
Diehl, Sean, Chow, Chi-Wing, Weiss, Linda, Palmetshofer, Alois, Twardzik, Thomas, Rounds, Laura, ...
Interleukin (IL)-6 is produced by professional antigen-presenting cells (APCs) such as B cells, macrophages, and dendritic cells. It has been previously shown that APC-derived IL-6 promotes the...
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation
Conze, Dietrich, Krahl, Troy, Kennedy, Norman, Weiss, Linda, Lumsden, Joanne, Hess, Patricia, ...
The c-Jun NH2-terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathway depends...
Diehl, Nicole L., Enslen, Hervé, Fortner, Karen A., Merritt, Chris, Stetson, Nate, Charland, Colette, ...
The development of T cells in the thymus is coordinated by cell-specific gene expression programs that involve multiple transcription factors and signaling pathways. Here, we show that the p38...
Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation
Weiss, Linda, Whitmarsh, Alan J., Yang, Derek D., Rincón, Mercedes, Davis, Roger J., Flavell, Richard A.
The c-Jun NH2-terminal kinases (JNKs) are a group of mitogen-activated protein (MAP) kinases that participate in signal transduction events mediating specific cellular functions. Activation of JNK is...
Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells
Rincón, Mercedes, Anguita, Juan, Nakamura, Tetsuo, Fikrig, Erol, Flavell, Richard A.
Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of Th1...
The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes
Rincón, Mercedes, Whitmarsh, Alan, Yang, Derek D., Weiss, Linda, Dérijard, Benoit, Jayaraj, Prash, ...
The extracellular signal-regulated kinase (ERK), the c-Jun NH2-terminal kinase (JNK), and p38 MAP kinase pathways are triggered upon ligation of the antigen-specific T cell receptor (TCR). During the...
Requirement of transcription factor NFAT in developing atrial myocardium
Schubert, William, Yang, Xiao Yong, Yang, Teddy T.C., Factor, Stephen M., Lisanti, Michael P., Molkentin, Jeffery D., ...
Nuclear factor of activated T cell (NFAT) is a ubiquitous regulator involved in multiple biological processes. Here, we demonstrate that NFAT is temporally required in the developing atrial...
Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos
Manning, Christopher B., Sabo-Attwood, Tara, Robledo, Raymond F., MacPherson, Maximilian B., Rincón, Mercedes, Vacek, Pamela, ...
The extracellular signal–regulated kinases 1 and 2 (ERK1/2) are phosphorylated after inhalation of asbestos. The effect of blocking this signaling pathway in lung epithelium is unclear....