Bacillus anthracis: Balancing innocent research with dual-use potential (2008)
Hudson, Michael J., Beyer, Wolfgang, Böhm, Reinhard, Fasanella, Antonio, Garofolo, Giuliano, Golinski, Robert, ...
Primary Involvement of Pharynx and Peyer's Patch in Inhalational and Intestinal Anthrax (2007)
Ian J. Glomski, Alejandro Piris-Gimenez, Michel Huerre, Michèle Mock, Pierre L. Goossens
Bacillus anthracis causes three forms of anthrax: inhalational, gastrointestinal, and cutaneous. Anthrax is characterized by both toxemia, which is caused by secretion of immunomodulating toxins...
Screening inhibitors of anthrax lethal factor (2002)
Tonello, Fiorella, Seveso, Michela, Marin, Oriano, Mock, Michèle, Montecucco, Cesare
The disease anthrax is caused by lethal factor, an enzyme component of the toxin produced by the spore-forming bacterium Bacillus anthracis. Here we describe substrate molecules for this factor that...
Mock, Michèle, Miyada, C. Garrett, Gunsalus, Robert P.
We have determined the nucleotide sequence of a segment of Co1E3 DNA coding for the carboxyl–terminal, catalytic peptide of colicin E3 and for the immunity protein. The end of the colicin E3 gene...
Mesnage, Stéphane, Weber-Levy, Martine, Haustant, Michel, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B....
Brossier, Fabien, Weber-Levy, Martine, Mock, Michèle, Sirard, Jean-Claude
Bacillus anthracis secretes a lethal toxin composed of two proteins, the lethal factor (LF) and the protective antigen (PA), which interact within the host or in vitro at the surfaces of eukaryotic...
Molecular Characterization of Bacillus Strains Involved in Outbreaks of Anthrax in France in 1997
Patra, Guy, Vaissaire, Josée, Weber-Levy, Martine, Le Doujet, Claudine, Mock, Michèle
Outbreaks of anthrax zoonose occurred in two regions of France in 1997. Ninety-four animals died, and there were three nonfatal cases in humans. The diagnosis of anthrax was rapidly confirmed by...
Mesnage, Stéphane, Tosi-Couture, Evelyne, Gounon, Pierre, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the etiological agent of anthrax, is a gram-positive spore-forming bacterium. Fully virulent bacilli are toxinogenic and capsulated. Two abundant surface proteins, including the...
Anthrax Spores Make an Essential Contribution to Vaccine Efficacy
Brossier, Fabien, Levy, Martine, Mock, Michèle
Anthrax is caused by Bacillus anthracis, a gram-positive spore-forming bacterium. Septicemia and toxemia rapidly lead to death in infected mammal hosts. Currently used acellular vaccines against...
Sylvestre, Patricia, Couture-Tosi, Evelyne, Mock, Michèle
We recently identified a Bacillus anthracis glycoprotein which is a structural constituent of the exosporium filaments (P. Sylvestre, E. Couture-Tosi, and M. Mock, Mol. Microbiol. 45:169-178, 2002)....
Diversity among French Bacillus anthracis Isolates
Fouet, Agnès, Smith, Kimothy L., Keys, Chris, Vaissaire, Josée, Le Doujet, Claudine, Lévy, Martine, ...
While outbreaks of animal anthrax zoonoses still regularly occur in France, little is known about the epidemiology links between them. We have used the eight-locus multilocus variable-number tandem...
The BtuB Group Col Plasmids and Homology Between the Colicins They Encode
Mock, Michèle, Pugsley, Anthony P.
Colicins A, E1, E2, E3, E4, E5, E6, and E7 exhibited reduced activity against BtuB mutants of Escherichia coli K-12 and also against wild-type cells in the presence of vitamin B12. Plasmids encoding...
Action of Lysozyme on Penicillin-Induced Filaments of Proteus vulgaris
Fleck, Jacqueline, Martin, Jean-Pierre, Mock, Michèle
Penicillin-induced filaments of Proteus vulgaris P 18 had a seemingly unaltered cell envelope. Lysozyme, however, reduced the wall part of these filaments into a three-layered structure and caused...
Mesnage, Stéphane, Fontaine, Thierry, Mignot, Tâm, Delepierre, Muriel, Mock, Michèle, Fouet, Agnès
Several bacterial proteins are non-covalently anchored to the cell surface via an S-layer homology (SLH) domain. Previous studies have suggested that this cell surface display mechanism involves a...
Distinct Mutations in PlcR Explain Why Some Strains of the Bacillus cereus Group Are Nonhemolytic
Slamti, Leyla, Perchat, Stéphane, Gominet, Myriam, Vilas-Bôas, Gislayne, Fouet, Agnès, Mock, Michèle, ...
Bacillus thuringiensis, Bacillus cereus, and Bacillus anthracis are closely related species belonging to the Bacillus cereus group. B. thuringiensis and B. cereus generally produce extracellular...
Brossier, Fabien, Lévy, Martine, Landier, Annie, Lafaye, Pierre, Mock, Michèle
Protective antigen (PA) is central to the action of the lethal and edema toxins produced by Bacillus anthracis. It is the common cell-binding component, mediating the translocation of the enzymatic...
Sylvestre, Patricia, Couture-Tosi, Evelyne, Mock, Michèle
Spores of Bacillus anthracis, the etiological agent of anthrax, and the closely related species Bacillus cereus and Bacillus thuringiensis, possess an exosporium, which is the outermost structure...
Identification of the Bacillus anthracis γ Phage Receptor
Davison, Sophie, Couture-Tosi, Evelyne, Candela, Thomas, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, a gram-positive, spore-forming bacterium, is the etiological agent of anthrax. It belongs to the Bacillus cereus group, which also contains Bacillus cereus and Bacillus...
CapE, a 47-Amino-Acid Peptide, Is Necessary for Bacillus anthracis Polyglutamate Capsule Synthesis
Candela, Thomas, Mock, Michèle, Fouet, Agnès
Polyglutamate is found in various bacteria, but displays different functions depending on the species and their environment. Here, we describe a minimal polyglutamate synthesis system in Bacillus...
Potent inhibitors of anthrax lethal factor from green tea
Dell'Aica, Isabella, Donà, Massimo, Tonello, Fiorella, Piris, Alejandro, Mock, Michèle, Montecucco, Cesare, ...
The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the...
Mesnage, Stéphane, Weber-Levy, Martine, Haustant, Michel, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the causal agent of anthrax, synthesizes two surface layer (S-layer) proteins, EA1 and Sap, which account for 5 to 10% of total protein and are expressed in vivo. A recombinant B....
Brossier, Fabien, Weber-Levy, Martine, Mock, Michèle, Sirard, Jean-Claude
Bacillus anthracis secretes a lethal toxin composed of two proteins, the lethal factor (LF) and the protective antigen (PA), which interact within the host or in vitro at the surfaces of eukaryotic...
Molecular Characterization of Bacillus Strains Involved in Outbreaks of Anthrax in France in 1997
Patra, Guy, Vaissaire, Josée, Weber-Levy, Martine, Le Doujet, Claudine, Mock, Michèle
Outbreaks of anthrax zoonose occurred in two regions of France in 1997. Ninety-four animals died, and there were three nonfatal cases in humans. The diagnosis of anthrax was rapidly confirmed by...
Mesnage, Stéphane, Tosi-Couture, Evelyne, Gounon, Pierre, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, the etiological agent of anthrax, is a gram-positive spore-forming bacterium. Fully virulent bacilli are toxinogenic and capsulated. Two abundant surface proteins, including the...
Anthrax Spores Make an Essential Contribution to Vaccine Efficacy
Brossier, Fabien, Levy, Martine, Mock, Michèle
Anthrax is caused by Bacillus anthracis, a gram-positive spore-forming bacterium. Septicemia and toxemia rapidly lead to death in infected mammal hosts. Currently used acellular vaccines against...
Sylvestre, Patricia, Couture-Tosi, Evelyne, Mock, Michèle
We recently identified a Bacillus anthracis glycoprotein which is a structural constituent of the exosporium filaments (P. Sylvestre, E. Couture-Tosi, and M. Mock, Mol. Microbiol. 45:169-178, 2002)....
Diversity among French Bacillus anthracis Isolates
Fouet, Agnès, Smith, Kimothy L., Keys, Chris, Vaissaire, Josée, Le Doujet, Claudine, Lévy, Martine, ...
While outbreaks of animal anthrax zoonoses still regularly occur in France, little is known about the epidemiology links between them. We have used the eight-locus multilocus variable-number tandem...
The BtuB Group Col Plasmids and Homology Between the Colicins They Encode
Mock, Michèle, Pugsley, Anthony P.
Colicins A, E1, E2, E3, E4, E5, E6, and E7 exhibited reduced activity against BtuB mutants of Escherichia coli K-12 and also against wild-type cells in the presence of vitamin B12. Plasmids encoding...
Action of Lysozyme on Penicillin-Induced Filaments of Proteus vulgaris
Fleck, Jacqueline, Martin, Jean-Pierre, Mock, Michèle
Penicillin-induced filaments of Proteus vulgaris P 18 had a seemingly unaltered cell envelope. Lysozyme, however, reduced the wall part of these filaments into a three-layered structure and caused...
Mesnage, Stéphane, Fontaine, Thierry, Mignot, Tâm, Delepierre, Muriel, Mock, Michèle, Fouet, Agnès
Several bacterial proteins are non-covalently anchored to the cell surface via an S-layer homology (SLH) domain. Previous studies have suggested that this cell surface display mechanism involves a...
Distinct Mutations in PlcR Explain Why Some Strains of the Bacillus cereus Group Are Nonhemolytic
Slamti, Leyla, Perchat, Stéphane, Gominet, Myriam, Vilas-Bôas, Gislayne, Fouet, Agnès, Mock, Michèle, ...
Bacillus thuringiensis, Bacillus cereus, and Bacillus anthracis are closely related species belonging to the Bacillus cereus group. B. thuringiensis and B. cereus generally produce extracellular...
Brossier, Fabien, Lévy, Martine, Landier, Annie, Lafaye, Pierre, Mock, Michèle
Protective antigen (PA) is central to the action of the lethal and edema toxins produced by Bacillus anthracis. It is the common cell-binding component, mediating the translocation of the enzymatic...
Sylvestre, Patricia, Couture-Tosi, Evelyne, Mock, Michèle
Spores of Bacillus anthracis, the etiological agent of anthrax, and the closely related species Bacillus cereus and Bacillus thuringiensis, possess an exosporium, which is the outermost structure...
Identification of the Bacillus anthracis γ Phage Receptor
Davison, Sophie, Couture-Tosi, Evelyne, Candela, Thomas, Mock, Michèle, Fouet, Agnès
Bacillus anthracis, a gram-positive, spore-forming bacterium, is the etiological agent of anthrax. It belongs to the Bacillus cereus group, which also contains Bacillus cereus and Bacillus...
CapE, a 47-Amino-Acid Peptide, Is Necessary for Bacillus anthracis Polyglutamate Capsule Synthesis
Candela, Thomas, Mock, Michèle, Fouet, Agnès
Polyglutamate is found in various bacteria, but displays different functions depending on the species and their environment. Here, we describe a minimal polyglutamate synthesis system in Bacillus...
Potent inhibitors of anthrax lethal factor from green tea
Dell'Aica, Isabella, Donà, Massimo, Tonello, Fiorella, Piris, Alejandro, Mock, Michèle, Montecucco, Cesare, ...
The anthrax lethal factor (LF) has a major role in the development of anthrax. LF is delivered by the protective antigen (PA) inside the cell, where it exerts its metalloprotease activity on the...
Primary Involvement of Pharynx and Peyer's Patch in Inhalational and Intestinal Anthrax
Glomski, Ian J, Piris-Gimenez, Alejandro, Huerre, Michel, Mock, Michèle, Goossens, Pierre L
Bacillus anthracis causes three forms of anthrax: inhalational, gastrointestinal, and cutaneous. Anthrax is characterized by both toxemia, which is caused by secretion of immunomodulating toxins...
Glomski, Ian J., Corre, Jean-Philippe, Mock, Michèle, Goossens, Pierre L.
Bacillus anthracis is a spore-forming bacterium that causes anthrax. B. anthracis has three major virulence factors, namely, lethal toxin, edema toxin, and a poly-γ-d-glutamic acid capsule. The...
Gauthier, Yves P., Tournier, Jean-Nicolas, Paucod, Jean-Charles, Corre, Jean-Philippe, Mock, Michèle, Goossens, Pierre L., ...
Protective antigen (PA)-based anthrax vaccines acting on toxins are less effective than live attenuated vaccines, suggesting that additional antigens may contribute to protective immunity. Several...