Lew, Betina J., Collins, Loretta L., O'Reilly, Michael A., Lawrence, B. Paige
Exposure to the aryl hydrocarbon receptor (AhR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during pregnancy causes severe defects in mammary gland development and function; however, the...
p53-Dependent Induction of p21Cip1/WAF1/Sdi1 Protects against Oxygen-Induced Toxicity (2001)
Helt, Christopher E., Rancourt, Raymond C., Staversky, Rhonda J., O'Reilly, Michael A.
The beneficial effects of supplemental oxygen delivered to patients suffering from acute respiratory distress is offset by its reduction to genotoxic reactive oxygen species (ROS) that inhibit...
Johnston, Carl J., Driscoll, Kevin E., Finkelstein, Jacob N., Baggs, R., O'Reilly, Michael A., Carter, Janet, ...
Chronic inhalation of crystalline silica can produce lung tumors in rats whereas this has not been shown for amorphous silica. At present the mechanisms underlying this rat lung tumor response are...
DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
Su, Chuan, Gao, Guang, Schneider, Sandra, Helt, Christopher, Weiss, Carsten, O'Reilly, Michael A, ...
Activation of the G1 checkpoint following DNA damage leads to inhibition of cyclin E–Cdk2 and subsequent G1 arrest in higher eucaryotes. Little, however, is known about the molecular events...
DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway
Su, Chuan, Gao, Guang, Schneider, Sandra, Helt, Christopher, Weiss, Carsten, O'Reilly, Michael A, ...
Activation of the G1 checkpoint following DNA damage leads to inhibition of cyclin E–Cdk2 and subsequent G1 arrest in higher eucaryotes. Little, however, is known about the molecular events...
Neonatal Hyperoxia Enhances the Inflammatory Response in Adult Mice Infected with Influenza A Virus
O'Reilly, Michael A., Marr, Shauna H., Yee, Min, McGrath-Morrow, Sharon A., Lawrence, B. Paige
Rationale: Lungs of adult mice exposed to hyperoxia as newborns are simplified and exhibit reduced function much like that observed in people who had bronchopulmonary dysplasia (BPD) as infants....
Disruption of p21 Attenuates Lung Inflammation Induced by Cigarette Smoke, LPS, and fMLP in Mice
Yao, Hongwei, Yang, Se-Ran, Edirisinghe, Indika, Rajendrasozhan, Saravanan, Caito, Samuel, Adenuga, David, ...
The cyclin-dependent kinase inhibitor p21CIP1/WAF1/SDI1 (p21) is an important inhibitory checkpoint regulator of cell cycle progression in response to oxidative and genotoxic stresses. It is known...