Hox go omics: insights from Drosophilainto Hox gene targets (2007)
Pavlopoulos, Anastasios, Akam, Michael
Abstract Genetic studies of the targets of the Hox genes have revealed only the tip of the iceberg. Recent microarray studies that have identified hundreds more transcriptional responses to Hox genes...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
Alonso, Claudio R., Akam, Michael
Nonsense mutations are usually assumed to affect protein function by generating truncated protein products. Nonetheless, it is now clear that these mutations affect not just protein synthesis but...
Hox genes in brachiopods and priapulids and protostome evolution (1999)
Renaud De Rosa, Jennifer K. Grenier, Tatiana Andreeva, Charles E. Cook, André Adoutte, Michael Akam, ...
Homology and developmental genes (1997)
Abouheif, Ehab, Akam, Michael, Dickinson, William J., Holland, Peter W. H., Meyer, Axel, Patel, Nipam H., ...
Oligonucleotide probes detect splicing variants in situ in Drosophila embryos (1992)
Artero, Rubén D., Akam, Michael, Pérez-Alonso, Manuel
We describe a method for the in situ detection of specific splicing variants. The method is based on the use of antisense oligonucleotides designed to span splice junctions labelled with digoxigenin...
Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria
Ferrier, David E. K., Akam, Michael
The conserved organization of the Hox genes throughout the animal kingdom has become one of the major paradigms of evolutionary developmental biology. We have examined the organization of the Hox...
Arthropods: Developmental diversity within a (super) phylum
The expression patterns of developmental genes provide new markers that address the homology of body parts and provide clues as to how body plans have evolved. Such markers support the idea that...
Alonso, Claudio R., Akam, Michael
Nonsense mutations are usually assumed to affect protein function by generating truncated protein products. Nonetheless, it is now clear that these mutations affect not just protein synthesis but...
Hox gene control of segment-specific bristle patterns in Drosophila
Rozowski, Marion, Akam, Michael
Hox genes specify the different morphologies of segments along the anteroposterior axis of animals. How they control complex segment morphologies is not well understood. We have studied how the Hox...
The structure and expression of a hybrid homeotic gene
We describe the structure and expression of an exceptional bithorax complex mutation, C1. This deletion mutation removes major portions of both the Ultrabithorax (Ubx) and abdominal-A (abd-A) protein...
Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit
Wilde, C. Deborah, Akam, Michael
Clones homologous to the 5' region of the Ultrabithorax gene of Drosophila melanogaster have been isolated from D. pseudoobscura, D. funebris and Musca domestica. Regions that encode most of the Ubx...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
Organization of the Hox gene cluster in the grasshopper, Schistocerca gregaria
Ferrier, David E. K., Akam, Michael
The conserved organization of the Hox genes throughout the animal kingdom has become one of the major paradigms of evolutionary developmental biology. We have examined the organization of the Hox...
Arthropods: Developmental diversity within a (super) phylum
The expression patterns of developmental genes provide new markers that address the homology of body parts and provide clues as to how body plans have evolved. Such markers support the idea that...
Alonso, Claudio R., Akam, Michael
Nonsense mutations are usually assumed to affect protein function by generating truncated protein products. Nonetheless, it is now clear that these mutations affect not just protein synthesis but...
Hox gene control of segment-specific bristle patterns in Drosophila
Rozowski, Marion, Akam, Michael
Hox genes specify the different morphologies of segments along the anteroposterior axis of animals. How they control complex segment morphologies is not well understood. We have studied how the Hox...
The structure and expression of a hybrid homeotic gene
We describe the structure and expression of an exceptional bithorax complex mutation, C1. This deletion mutation removes major portions of both the Ultrabithorax (Ubx) and abdominal-A (abd-A) protein...
Conserved sequence elements in the 5' region of the Ultrabithorax transcription unit
Wilde, C. Deborah, Akam, Michael
Clones homologous to the 5' region of the Ultrabithorax gene of Drosophila melanogaster have been isolated from D. pseudoobscura, D. funebris and Musca domestica. Regions that encode most of the Ubx...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
Hox go omics: insights from Drosophila into Hox gene targets
Pavlopoulos, Anastasios, Akam, Michael
Microarray analysis reveals hundreds of hitherto unsuspected Hox gene targets.
Mitochondrial genomes suggest that hexapods and crustaceans are mutually paraphyletic
Cook, Charles E, Yue, Qiaoyun, Akam, Michael
For over a century the relationships between the four major groups of the phylum Arthropoda (Chelicerata, Crustacea, Hexapoda and Myriapoda) have been debated. Recent molecular evidence has confirmed...
The evolution of hexapod engrailed-family genes: evidence for conservation and concerted evolution
Peel, Andrew D, Telford, Maximilian J, Akam, Michael
Phylogenetic analyses imply that multiple engrailed-family gene duplications occurred during hexapod evolution, a view supported by previous reports of only a single engrailed-family gene in members...
Gene Circuit Analysis of the Terminal Gap Gene huckebein
Ashyraliyev, Maksat, Siggens, Ken, Janssens, Hilde, Blom, Joke, Akam, Michael, Jaeger, Johannes
The early embryo of Drosophila melanogaster provides a powerful model system to study the role of genes in pattern formation. The gap gene network constitutes the first zygotic regulatory tier in the...
Pavlopoulos, Anastasios, Kontarakis, Zacharias, Liubicich, Danielle M., Serano, Julia M., Akam, Michael, Patel, Nipam H., ...
Changes in the expression of Hox genes have been widely linked to the evolution of animal body plans, but functional demonstrations of this relationship have been impeded by the lack of suitable...
Alternative Splicing Modulates Ubx Protein Function in Drosophila melanogaster
Reed, Hilary C., Hoare, Tim, Thomsen, Stefan, Weaver, Thomas A., White, Robert A. H., Akam, Michael, ...
The Drosophila Hox gene Ultrabithorax (Ubx) produces a family of protein isoforms through alternative splicing. Isoforms differ from one another by the presence of optional segments—encoded by...