Yates, Melinda S., Tran, Quynh T., Dolan, Patrick M., Osburn, William O., Shin, Soona, McCulloch, Colin C., ...
Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity, inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In contrast,...
Burrage, Peter S, Schmucker, Adam C, Ren, Yanqing, Sporn, Michael B, Brinckerhoff, Constance E
Abstract Introduction We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-β)-driven matrix metalloproteinase-1 ( MMP-1 ) and...
Tran, Thi A, McCoy, Melissa K, Sporn, Michael B, Tansey, Malú G
Abstract Background Recent animal and human studies implicate chronic activation of microglia in the progressive loss of CNS neurons. The inflammatory mechanisms that have neurotoxic effects and...
Osburn, William O., Yates, Melinda S., Dolan, Patrick D., Chen, Sining, Liby, Karen T., Sporn, Michael B., ...
Oxidative stress–mediated destruction of normal parenchymal cells during hepatic inflammatory responses contributes to the pathogenesis of immune-mediated hepatitis and is implicated in the...
Han, Seong-Su, Peng, Liangping, Chung, Seung-Tae, DuBois, Wendy, Maeng, Sung-Ho, Shaffer, Arthur L, ...
Abstract Background Gene-targeted iMyc Eμ mice that carry a His 6 -tagged mouse Myc (c- myc )cDNA, Myc His , just 5' of the immunoglobulin heavy-chain enhancer, Eμ, are prone to B cell and plasma...
New Approaches to Chemoprevention of Breast Cancer. (2003)
Triterpenoids, natural products related to steroids and retinoids, represent an important class of new structures for drug discovery, with potential applications in many fields of medicine,...
New Approaches to Chemoprevention of Breast Cancer. (2003)
Triterpenoids, natural products related to steroids and retinolds, represent an important class of new structures for drug discovery, with potential applications in many fields of medicine,...
Triterpenoids and Prevention of Prostate Cancer (2003)
This entire project is based on the hypothesis that we can design and develop new synthetic triterpenoids that would eventually be useful for chemoprevention of prostate cancer. With the known...
Triterpenoids and Prevention of Prostate Cancer (2003)
This entire project is based on the hypothesis that we can design and develop new synthetic triterpenoids that would eventually be useful for chemoprevention of prostate cancer. With the known...
Chemoprevention of cancer (2000)
Sporn, Michael B., Suh, Nanjoo
In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemopreventive agents based on...
Veronesi, Umberto, De Palo, Giuseppe, Marubini, Ettore, Costa, Alberto, Formelli, Franca, Mariani, Luigi, ...
BACKGROUND: Fenretinide, a vitamin A analogue, has been shown to inhibit breast carcinogenesis in preclinical studies. We determined the efficacy of fenretinide in preventing a second breast...
New Triterpenoids for Prevention of Breast Cancer (1998)
We have shown that the synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) is a highly potent inhibitor of the proliferation of several ER-positive and ER-negative human...
Anzano, Mario A., Peer, Christopher W., Smith, Joseph M., Mullen, Larry T., Shrader, Mark W., Logsdon, Daniel L., ...
Workshop on growth factors (1991)
Crowther, Derek, Sporn, Michael B., Roberts, Anita B., Durie, Brian G. M.
The ‘Workshop on Growth Factors’ which took place at the Lugano Lymphoma Conference on June 8, 1990, included a presentation by Michael Sporn on the concept that loss of inhibitory control...
Peptide growth factors and their receptors / contributors K. I. Arai... [et. al.] (1990)
Arai, Ken-Ichi, Sporn, Michael B., Roberts, Anita B
Incluye bibliografía e índice
Nucleotide sequence of chicken transforming growth factor-beta 1 (TGF-{beta} 1) (1988)
Jakowlew, Sonia B., Dillard, Pamela J., Sporn, Michael B., Roberts, Anita B.
2′-O-Methylation of Adenosine, Guanosine, Uridine, and Cytidine in RNA of Isolated Rat Liver Nuclei
Al-Arif, Adhid, Sporn, Michael B.
Nuclei isolated from rat liver, when incubated with methyl-labeled S-adenosylmethionine, incorporated label into 2′-O-methyladenosine, 2′-O-methylguanosine, 2′-O-methyluridine, and...
Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, ...
A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ of inducible nitric oxide synthase...
Vázquez, Nancy, Greenwell-Wild, Teresa, Marinos, Nancy J., Swaim, William D., Nares, Salvador, Ott, David E., ...
In contrast to CD4+ T cells, human immunodeficiency virus type 1 (HIV-1)-infected macrophages typically resist cell death, support viral replication, and consequently, may facilitate HIV-1...
Han, Seong-Su, Peng, Liangping, Chung, Seung-Tae, DuBois, Wendy, Maeng, Sung-Ho, Shaffer, Arthur L, ...
2′-O-Methylation of Adenosine, Guanosine, Uridine, and Cytidine in RNA of Isolated Rat Liver Nuclei
Al-Arif, Adhid, Sporn, Michael B.
Nuclei isolated from rat liver, when incubated with methyl-labeled S-adenosylmethionine, incorporated label into 2′-O-methyladenosine, 2′-O-methylguanosine, 2′-O-methyluridine, and...
Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, ...
A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ of inducible nitric oxide synthase...
Vázquez, Nancy, Greenwell-Wild, Teresa, Marinos, Nancy J., Swaim, William D., Nares, Salvador, Ott, David E., ...
In contrast to CD4+ T cells, human immunodeficiency virus type 1 (HIV-1)-infected macrophages typically resist cell death, support viral replication, and consequently, may facilitate HIV-1...
Han, Seong-Su, Peng, Liangping, Chung, Seung-Tae, DuBois, Wendy, Maeng, Sung-Ho, Shaffer, Arthur L, ...
THE ISOLATION OF CELL NUCLEI FROM RAT BRAIN
Sporn, Michael B., Wanko, Theodor, Dingman, Wesley
A method for preparing highly pure cell nuclei from adult rat brain, using both differential and isopycnic centrifugation in sucrose media, is described. The morphology of these preparations was...
Koschmieder, Steffen, D'Alò, Francesco, Radomska, Hanna, Schöneich, Christine, Chang, Ji Suk, Konopleva, Marina, ...
2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces differentiation and apoptosis of tumor cells in vitro and in vivo. Here we assessed the effects of CDDO on CCAAT enhancer–binding...
To, Ciric, Kulkarni, Sarang, Pawson, Tony, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., ...
The anti-tumor synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO)-imidazolide (CDDO-Im) ectopically activates the transforming growth factor β (TGFβ)-Smad pathway and...
Sussan, Thomas E., Rangasamy, Tirumalai, Blake, David J., Malhotra, Deepti, El-Haddad, Hazim, Bedja, Djahida, ...
Chronic obstructive pulmonary disease (COPD), which comprises emphysema and chronic bronchitis resulting from prolonged exposure to cigarette smoke (CS), is a major public health burden with no...