The combined status of ATM and p53 link tumor development with therapeutic response (2009)
Jiang, Hai, Reinhardt, H. Christian, Bartkova, Jirina, Tommiska, Johanna, Blomqvist, Carl, Nevanlinna, Heli, ...
While the contribution of specific tumor suppressor networks to cancer development has been the subject of considerable recent study, it remains unclear how alterations in these networks are...
Research and Departments of (2008)
Kevin A. Janes, Michael B. Yaffe
A table of numbers. Alternatively, a matrix can be viewed as an arrangement of row or column vectors.
Kevin A. Janes, John G. Albeck, Lili X. Peng, Peter K. Sorger, Douglas A. Lauffenburger, Michael B. Yaffe
To treat complex human diseases effectively, a systemslevel approach is needed to understand the interplay of environmental cues, intracellular signals, and cellular behaviors that underlie disease...
NetworKIN: a resource for exploring cellular phosphorylation networks (2008)
Linding, Rune, Jensen, Lars Juhl, Pasculescu, Adrian, Olhovsky, Marina, Colwill, Karen, Bork, Peer, ...
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in...
Signaling netwErks get the global treatment (2007)
Yaffe, Michael B, White, Forest M
Abstract Two landmark studies of cell signaling, by RNA interference and phosphoproteomics, provide complementary global views of the pathways downstream of receptor kinases, including those...
Orion D. Weiner, Maike C. Rentel, Alex Ott, Glenn E. Brown, Mark Jedrychowski, Michael B. Yaffe, ...
The authors describe a group of multiprotein complexes, scaffolded by Hem-1 (a subset of which also contain WAVE2), that are involved in generating and maintaining cellular polarity in neutrophils.
Orion D. Weiner, Maike C. Rentel, Alex Ott, Glenn E. Brown, Mark Jedrychowski, Michael B. Yaffe, ...
Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...
A positive feedback loop couples Ras activation and CD44 alternative splicing (2006)
Cheng, Chonghui, Yaffe, Michael B., Sharp, Phillip A.
The Ras signaling pathway is important in both cell proliferation and tumor progression. Alternatively spliced isoforms of CD44 containing variable exon 6 (v6) can serve as coreceptors for growth...
Mah, Angie S., Elia, Andrew E. H., Devgan, Geeta, Ptacek, Jason, Schutkowski, Mike, Snyder, Michael, ...
Background: The mitotic exit network (MEN) is a group of proteins that form a signaling cascade that is essential for cells to exit mitosis in Saccharomyces cerevisiae. The MEN has also been...
Mah, Angie S, Elia, Andrew EH, Devgan, Geeta, Ptacek, Jason, Schutkowski, Mike, Snyder, Michael, ...
Abstract Background The mitotic exit network (MEN) is a group of proteins that form a signaling cascade that is essential for cells to exit mitosis in Saccharomyces cerevisiae . The MEN has also been...
Joughin, Brian A., Tidor, Bruce, Yaffe, Michael B.
Phosphopeptide-binding domains, including the FHA, SH2, WW, WD40, MH2, and Polo-box domains, as well as the 14-3-3 proteins, exert control functions in important processes such as cell growth,...
Joughin, Brian A., Tidor, Bruce, Yaffe, Michael B.
Phosphopeptide-binding domains, including the FHA, SH2, WW, WD40, MH2, and Polo-box domains, as well as the 14-3-3 proteins, exert control functions in important processes such as cell growth,...
Obenauer, John C., Cantley, Lewis C., Yaffe, Michael B.
Scansite identifies short protein sequence motifs that are recognized by modular signaling domains, phosphorylated by protein Ser/Thr- or Tyr-kinases or mediate specific interactions with protein...
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade (2000)
Bunnell, Stephen C., Diehn, Maximilian, Yaffe, Michael B., Findell, Paul R., Cantley, Lewis C., Berg, Leslie J.
Itk, a Tec family tyrosine kinase, acts downstream of Lck and phosphatidylinositol 3'-kinase to facilitate T cell receptor (TCR)-dependent calcium influxes and increases in extracellular-regulated...
Morra, Massimo, Lu, Jun, Poy, Florence, Martin, Margarita, Sayos, Joan, Calpe, Silvia, ...
The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a ‘free SH2 domain’ that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface...
Powell, David W., Rane, Madhavi J., Joughin, Brian A., Kalmukova, Ralitsa, Hong, Jeong-Ho, Tidor, Bruce, ...
Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAPK2) mediates multiple p38 MAPK-dependent inflammatory responses. To define the signal transduction pathways activated by...
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs
Obenauer, John C., Cantley, Lewis C., Yaffe, Michael B.
Scansite identifies short protein sequence motifs that are recognized by modular signaling domains, phosphorylated by protein Ser/Thr- or Tyr-kinases or mediate specific interactions with protein or...
Kanai, Fumihiko, Marignani, Paola A., Sarbassova, Dilara, Yagi, Ryohei, Hall, Randy A., Donowitz, Mark, ...
The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal...
Master of all things phosphorylated.
Serine/threonine phosphorylation plays a central role in cellular regulation, either by altering a protein's activity directly or by inducing specific protein-protein interactions, which, in turn,...
Mah, Angie S, Elia, Andrew EH, Devgan, Geeta, Ptacek, Jason, Schutkowski, Mike, Snyder, Michael, ...
Weiner, Orion D, Rentel, Maike C, Ott, Alex, Brown, Glenn E, Jedrychowski, Mark, Yaffe, Michael B, ...
Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...
Morra, Massimo, Lu, Jun, Poy, Florence, Martin, Margarita, Sayos, Joan, Calpe, Silvia, ...
The T and natural killer (NK) cell-specific gene SAP (SH2D1A) encodes a ‘free SH2 domain’ that binds a specific tyrosine motif in the cytoplasmic tail of SLAM (CD150) and related cell surface...
Powell, David W., Rane, Madhavi J., Joughin, Brian A., Kalmukova, Ralitsa, Hong, Jeong-Ho, Tidor, Bruce, ...
Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAPK2) mediates multiple p38 MAPK-dependent inflammatory responses. To define the signal transduction pathways activated by...
Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs
Obenauer, John C., Cantley, Lewis C., Yaffe, Michael B.
Scansite identifies short protein sequence motifs that are recognized by modular signaling domains, phosphorylated by protein Ser/Thr- or Tyr-kinases or mediate specific interactions with protein or...
Kanai, Fumihiko, Marignani, Paola A., Sarbassova, Dilara, Yagi, Ryohei, Hall, Randy A., Donowitz, Mark, ...
The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal...
Master of all things phosphorylated.
Serine/threonine phosphorylation plays a central role in cellular regulation, either by altering a protein's activity directly or by inducing specific protein-protein interactions, which, in turn,...
Mah, Angie S, Elia, Andrew EH, Devgan, Geeta, Ptacek, Jason, Schutkowski, Mike, Snyder, Michael, ...
Weiner, Orion D, Rentel, Maike C, Ott, Alex, Brown, Glenn E, Jedrychowski, Mark, Yaffe, Michael B, ...
Migrating cells need to make different actin assemblies at the cell's leading and trailing edges and to maintain physical separation of signals for these assemblies. This asymmetric control of...
A positive feedback loop couples Ras activation and CD44 alternative splicing
Cheng, Chonghui, Yaffe, Michael B., Sharp, Phillip A.
The Ras signaling pathway is important in both cell proliferation and tumor progression. Alternatively spliced isoforms of CD44 containing variable exon 6 (v6) can serve as coreceptors for growth...
Signaling netwErks get the global treatment
Yaffe, Michael B, White, Forest M
Two landmark analyses of signaling networks by RNAi and phosphoproteomics provide complementary snapshots of the phosphoproteome.
TAZ Promotes PC2 Degradation through a SCFβ-Trcp E3 Ligase Complex▿ †
Tian, Yu, Kolb, Robert, Hong, Jeong-Ho, Carroll, John, Li, Dawei, You, John, ...
Studies of a TAZ knockout mouse reveal a novel function of the transcriptional regulator TAZ, that is, as a binding partner of the F-box protein β-Trcp. TAZ−/− mice develop polycystic kidney...
Suh, Chang-Il, Stull, Natalie D., Li, Xing Jun, Tian, Wei, Price, Marianne O., Grinstein, Sergio, ...
Superoxide produced by the phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is essential for host defense. Enzyme activation requires translocation of p67phox, p47phox,...
NetworKIN: a resource for exploring cellular phosphorylation networks
Linding, Rune, Jensen, Lars Juhl, Pasculescu, Adrian, Olhovsky, Marina, Colwill, Karen, Bork, Peer, ...
Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in...
A computational method for the analysis and prediction of protein:phosphopeptide-binding sites
Joughin, Brian A., Tidor, Bruce, Yaffe, Michael B.
Phosphopeptide-binding domains, including the FHA, SH2, WW, WD40, MH2, and Polo-box domains, as well as the 14-3-3 proteins, exert control functions in important processes such as cell growth,...
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate
Lowery, Drew M, Clauser, Karl R, Hjerrild, Majbrit, Lim, Dan, Alexander, Jes, Kishi, Kazuhiro, ...
Polo-like kinase-1 (Plk1) phosphorylates a number of mitotic substrates, but the diversity of Plk1-dependent processes suggests the existence of additional targets. Plk1 contains a specialized...
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
Brunet, Anne, Kanai, Fumihiko, Stehn, Justine, Xu, Jian, Sarbassova, Dilara, Frangioni, John V., ...
14-3-3 proteins regulate the cell cycle and prevent apoptosis by controlling the nuclear and cytoplasmic distribution of signaling molecules with which they interact. Although the majority of 14-3-3...
Polo-Like Kinase-1 Controls Aurora A Destruction by Activating APC/C-Cdh1
Van Leuken, Renske, Clijsters, Linda, Van Zon, Wouter, Lim, Dan, Yao, XueBiao, Wolthuis, Rob M. F., ...
Polo-like kinase-1 (Plk1) is activated before mitosis by Aurora A and its cofactor Bora. In mitosis, Bora is degraded in a manner dependent on Plk1 kinase activity and the E3 ubiquitin ligase...
Burkard, Mark E., Maciejowski, John, Rodriguez-Bravo, Verónica, Repka, Michael, Lowery, Drew M., Clauser, Karl R., ...
Self-regulated movement of Polo-like kinase 1 to the midzone of the mitotic spindle initiates a local signaling cascade that activates the cell division machinery at the cell's equator.
Distinct mechanisms act in concert to mediate cell cycle arrest
Toettcher, Jared E., Loewer, Alexander, Ostheimer, Gerard J., Yaffe, Michael B., Tidor, Bruce, Lahav, Galit
In response to DNA damage, cells arrest at specific stages in the cell cycle. This arrest must fulfill at least 3 requirements: it must be activated promptly; it must be sustained as long as damage...
Edbauer, Dieter, Cheng, Dongmei, Batterton, Matthew N., Wang, Chi-Fong, Duong, Duc M., Yaffe, Michael B., ...
Mitogen-activated protein kinases (MAPKs) control neuronal synaptic function; however, little is known about the synaptic substrates regulated by MAPKs. A phosphopeptide library incorporating the...
Tian, Wei, Li, Xing Jun, Stull, Natalie D., Ming, Wenyu, Suh, Chang-Il, Bissonnette, Sarah A., ...
The phagocyte NADPH oxidase generates superoxide for microbial killing, and includes a membrane-bound flavocytochrome b558 and cytosolic p67phox, p47phox, and p40phox subunits that undergo membrane...