Michael Eckhaus

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. (2000)

Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...

We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient (Atm-/-)...

Life without white fat: a transgenic mouse (1998)

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...

We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...

The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...

Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene

Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, ...

Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of...

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...

Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...

RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice

Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...

Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...

Enhanced Mucosal Immunoglobulin A Response of Intranasal Adenoviral Vector Human Immunodeficiency Virus Vaccine and Localization in the Central Nervous System

Lemiale, Franck, Kong, Wing-pui, Akyürek, Levent M., Ling, Xu, Huang, Yue, Chakrabarti, Bimal K., ...

Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation

Barlow, Carrolee, Ribaut-Barassin, Catherine, Zwingman, Theresa A., Pope, Amber J., Brown, Kevin D., Owens, Jennie W., ...

We previously generated a mouse model with a mutation in the murine Atm gene that recapitulates many aspects of the childhood neurodegenerative disease ataxia-telangiectasia. Atm-deficient...

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice

Petiniot, Lisa K., Weaver, Zoë, Barlow, Carrolee, Shen, Rhuna, Eckhaus, Michael, Steinberg, Seth M., ...

The majority of Atm-deficient mice die of malignant thymic lymphoma by 4–5 mo of age. Cytogenetic abnormalities in these tumors are consistently identified within the Tcr α/δ locus, suggesting...

Variable and tissue-specific hormone resistance in heterotrimeric Gs protein α-subunit (Gsα) knockout mice is due to tissue-specific imprinting of the Gsα gene

Yu, Shuhua, Yu, Dawen, Lee, Eric, Eckhaus, Michael, Lee, Randy, Corria, Zakia, ...

Albright hereditary osteodystrophy (AHO), an autosomal dominant disorder characterized by short stature, obesity, and skeletal defects, is associated with heterozygous inactivating mutations of...

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, ...

Polymorphonuclear leukocytes are essential for host defense to infectious diseases. CCAAT/enhancer binding protein ɛ (C/EBPɛ) is preferentially expressed in granulocytes and lymphoid cells. Mice...

RAG-Mediated V(D)J Recombination Is Not Essential for Tumorigenesis in Atm-Deficient Mice

Petiniot, Lisa K., Weaver, Zoë, Vacchio, Melanie, Shen, Rhuna, Wangsa, Danny, Barlow, Carrolee, ...

Atm-deficient mice die of malignant thymic lymphomas characterized by translocations within the Tcrα/δ locus, suggesting that tumorigenesis is secondary to aberrant responses to double-stranded DNA...

Enhanced Mucosal Immunoglobulin A Response of Intranasal Adenoviral Vector Human Immunodeficiency Virus Vaccine and Localization in the Central Nervous System

Lemiale, Franck, Kong, Wing-pui, Akyürek, Levent M., Ling, Xu, Huang, Yue, Chakrabarti, Bimal K., ...

Replication-defective adenovirus (ADV) vectors represent a promising potential platform for the development of a vaccine for AIDS. Although this vector is typically administered intramuscularly, it...

Life without white fat: a transgenic mouse

Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...

We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...

Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice

Gavrilova, Oksana, Marcus-Samuels, Bernice, Graham, David, Kim, Jason K., Shulman, Gerald I., Castle, Arthur L., ...

In lipoatrophic diabetes, a lack of fat is associated with insulin resistance and hyperglycemia. This is in striking contrast to the usual association of diabetes with obesity. To understand the...

Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma

Kundu, Mondira, Compton, Sheila, Garrett-Beal, Lisa, Stacy, Terryl, Starost, Matthew F., Eckhaus, Michael, ...

Chromosomal rearrangements affecting RUNX1 and CBFB are common in acute leukemias. These mutations result in the expression of fusion proteins that act dominant-negatively to suppress the normal...

Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax▿

Sheleg, Sergey V., Peloponese, Jean-Marie, Chi, Ya-Hui, Li, Yan, Eckhaus, Michael, Jeang, Kuan-Teh

Aneuploidy is frequent in cancers. Recently it was found that pituitary tumor transforming gene (PTTG; also called Pds1p or securin) is overexpressed in many different tumors. Human T-cell leukemia...