Nassir, Rami, Kosoy, Roman, Tian, Chao, White, Phoebe A, Butler, Lesley M, Silva, Gabriel, ...
Abstract Background Case-control genetic studies of complex human diseases can be confounded by population stratification. This issue can be addressed using panels of ancestry informative markers...
Chang, Jeffrey S., Wrensch, Margaret R., Hansen, Helen M., Sison, Jennette D., Aldrich, Melinda C., Quesenberry, Charles P., ...
Base excision repair (BER) is the primary DNA damage repair mechanism for repairing small base lesions resulting from oxidation and alkylation damage. This study examines the association between 24...
Analysis and Application of European Genetic Substructure Using 300 K SNP Information (2008)
Chao Tian, Robert M. Plenge, Michael Ransom, Annette Lee, Pablo Villoslada, Carlo Selmi, ...
European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses...
Aldrich, Melinda C., Selvin, Steve, Hansen, Helen M., Barcellos, Lisa F., Wrensch, Margaret R., Sison, Jennette D., ...
A variety of methods are available for estimating genetic admixture proportions in populations; however, few investigators have conducted detailed comparisons using empirical data. The authors...
Accounting for ancestry: population substructure and genome-wide association studies (2008)
Tian, Chao, Gregersen, Peter K., Seldin, Michael F.
Accounting for the genetic substructure of human populations has become a major practical issue for studying complex genetic disorders. Allele frequency differences among ethnic groups and subgroups...
Amos, Christopher I, Chen, Wei, Remmers, Elaine, Siminovitch, Katherine A, Seldin, Michael F, Criswell, Lindsey A, ...
Abstract For Genetic Analysis Workshop 15 Problem 2, we organized data from several ongoing studies designed to identify genetic and environmental risk factors for rheumatoid arthritis. Data were...
Leukocyte Antigens And, Damini Jawaheer, Wentian Li, Robert R. Graham, Wei Chen, Aarti Damle, ...
are present within the major histocompatibility complex. One of these lies within a 497-kb region in the central portion of the HLA complex, an interval that excludes DRB1. This genetic risk factor...
European Population Substructure: Clustering of Northern and Southern Populations (2006)
Michael F. Seldin, Russell Shigeta, Pablo Villoslada, Carlo Selmi, Jaakko Tuomilehto, Gabriel Silva, ...
Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there...
European Population Substructure: Clustering of Northern and Southern Populations (2006)
Michael F Seldin, Russell Shigeta, Pablo Villoslada, Carlo Selmi, Jaakko Tuomilehto, Gabriel Silva, ...
The development of methodologies for defining population genetic structure has provided the ability to identify the major ethnic contributions in individual subjects in diverse populations. Using a...
Seldin, Michael F., Morii, Takanobu, Collins-Schramm, Heather E., Chima, Bill, Kittles, Rick, Criswell, Lindsey A., ...
Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative...
Seldin, Michael F., Morii, Takanobu, Collins-Schramm, Heather E., Chima, Bill, Kittles, Rick, Criswell, Lindsey A., ...
Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative...
A Hidden Markov Modeling Approach for Admixture Mapping Based on Case-Control Haplotype Data (2003)
Zhang, Chun, Chen, Kun, Seldin, Michael F, Li, Hongzhe
Admixture mapping is potentially a powerful method for mapping genes for complex human diseases, when the disease frequency due to a particular disease susceptible gene is different between founding...
Differentiation-specific effects of LHON mutations introduced into neuronal NT2 cells (2002)
Wong, Alice, Cavelier, Lucia, Collins-Schramm, Heather E., Seldin, Michael F., McGrogan, Michael, Savontaus, Marja-Liisa, ...
Inheritance of one of three primary mutations at positions 11778, 3460 or 14484 of the mitochondrial genome in subunits of Complex I causes Leber’s Hereditary Optic Neuropathy (LHON), a specific...
Todd, John A., Seldin, Michael F., Prins, Jan-Bas, Rodrigues, Nanda R., Meisler, Miriam H.
Peer Reviewed
Wright, Mark D., Rochelle, Julie M., Tomlinson, Michael G., Seldin, Michael F., Williams, Alan F., Hunig, T.
CD53 is a pan-leukocyte surface glycoprotein which spans the plasma membrane four times and is a member of the transmembrane 4 superfamily (TM4SF). The protein sequence and gene structure of mouse...
Jones, Julie M., Meisler, Miriam H., Seldin, Michael F., Lee, Barbara K., Eicher, Eva M.
A DNA mapping panel derived from an interspecific backcross was used to position the mouse insulin-2 locus (Ins-2) on Chromosome 7, near H19 (0/114 recombinants) and Th (1/114 recombinants). Ins-2 is...
Wakeland, Edward K., Seldin, Michael F., Rodrigues, Nanda R., Todd, John A., Meisler, Miriam H.
Peer Reviewed
Oakey, Rebecca J., Watson, Mark L., Seldin, Michael F.
Long range restriction site maps of 13 Mb of mouse chromosome 1 and 11 Mb of human chromosome 1 were constructed using a framework provided by a detailed mouse genetic map. Where an unambiguous gene...
Taylor, Gregory A., Lai, Wi S., Oakey, Rebecca J., Seldin, Michael F., Shows, Thomas B., Eddy, Roger L., ...
The mouse tristetraprolin (TTP) protein is a basic proline-nch protein of Mr 33,600 that contains three PPPPG repeats (1). Its mRNA levels increase dramatically after stimulation with various...
Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, Lingxiang, Hathcock, Karen S., Hande, Prakash, Lansdorp, Peter M., Seldin, Michael F., Hodes, Richard J.
Little is known about the mechanisms that regulate species-specific telomere length, particularly in mammalian species. The genetic regulation of telomere length was therefore investigated by using...
Recognition of Hapten-Modified Cells In Vitro by Human T Lymphocytes
Seldin, Michael F., Rich, Robert R., Abramson, Stuart L.
Clearer definition of the recognitive structures of human T lymphocytes for antigens will be required to elucidate the molecular basis of diseases and immunological responses induced or regulated by...
Seldin, Michael F., Morii, Takanobu, Collins-Schramm, Heather E., Chima, Bill, Kittles, Rick, Criswell, Lindsey A., ...
Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative...
Begovich, Ann B., Carlton, Victoria E. H., Honigberg, Lee A., Schrodi, Steven J., Chokkalingam, Anand P., Alexander, Heather C., ...
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1% of the adult population worldwide, with an estimated heritability of 60%. To identify genes involved in RA...
Jawaheer, Damini, Seldin, Michael F., Amos, Christopher I., Chen, Wei V., Shigeta, Russell, Monteiro, Joanita, ...
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex families with RA gathered in the United...
European Population Substructure: Clustering of Northern and Southern Populations
Seldin, Michael F, Shigeta, Russell, Villoslada, Pablo, Selmi, Carlo, Tuomilehto, Jaakko, Silva, Gabriel, ...
Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there...
Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, Lingxiang, Hathcock, Karen S., Hande, Prakash, Lansdorp, Peter M., Seldin, Michael F., Hodes, Richard J.
Little is known about the mechanisms that regulate species-specific telomere length, particularly in mammalian species. The genetic regulation of telomere length was therefore investigated by using...
Recognition of Hapten-Modified Cells In Vitro by Human T Lymphocytes
Seldin, Michael F., Rich, Robert R., Abramson, Stuart L.
Clearer definition of the recognitive structures of human T lymphocytes for antigens will be required to elucidate the molecular basis of diseases and immunological responses induced or regulated by...
Ethnic-Difference Markers for Use in Mapping by Admixture Linkage Disequilibrium
Collins-Schramm, Heather E., Phillips, Carolyn M., Operario, Darwin J., Lee, Jane S., Weber, James L., Hanson, Robert L., ...
Mapping by admixture linkage disequilibrium (MALD) is a potentially powerful technique for the mapping of complex genetic diseases. The practical requirements of this method include (a) a set of...
Seldin, Michael F., Morii, Takanobu, Collins-Schramm, Heather E., Chima, Bill, Kittles, Rick, Criswell, Lindsey A., ...
Theoretically, markers that distinguish European from West African ancestry can be used to examine the origin of chromosomal segments in individual African Americans. In this study, putative...
Jawaheer, Damini, Li, Wentian, Graham, Robert R., Chen, Wei, Damle, Aarti, Xiao, Xiangli, ...
Rheumatoid arthritis (RA) is an inflammatory disease with a complex genetic component. An association between RA and the human leukocyte antigen (HLA) complex has long been observed in many different...
Begovich, Ann B., Carlton, Victoria E. H., Honigberg, Lee A., Schrodi, Steven J., Chokkalingam, Anand P., Alexander, Heather C., ...
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1% of the adult population worldwide, with an estimated heritability of 60%. To identify genes involved in RA...
PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis
Carlton, Victoria E. H., Hu, Xiaolan, Chokkalingam, Anand P., Schrodi, Steven J., Brandon, Rhonda, Alexander, Heather C., ...
The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein tyrosine phosphatase gene, PTPN22, has been associated with multiple...
Jawaheer, Damini, Seldin, Michael F., Amos, Christopher I., Chen, Wei V., Shigeta, Russell, Monteiro, Joanita, ...
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. We report the first major genomewide screen of multiplex families with RA gathered in the United...
European Population Substructure: Clustering of Northern and Southern Populations
Seldin, Michael F, Shigeta, Russell, Villoslada, Pablo, Selmi, Carlo, Tuomilehto, Jaakko, Silva, Gabriel, ...
Using a genome-wide single nucleotide polymorphism (SNP) panel, we observed population structure in a diverse group of Europeans and European Americans. Under a variety of conditions and tests, there...
Tian, Chao, Hinds, David A., Shigeta, Russell, Kittles, Rick, Ballinger, Dennis G., Seldin, Michael F.
Admixture mapping requires a genomewide panel of relatively evenly spaced markers that can distinguish the ancestral origins of chromosomal segments in admixed individuals. Through use of the results...
Analysis and Application of European Genetic Substructure Using 300 K SNP Information
Tian, Chao, Plenge, Robert M, Ransom, Michael, Lee, Annette, Villoslada, Pablo, Selmi, Carlo, ...
European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both STRUCTURE and principal component analyses...
Gilkeson, Gary S., Mudgett, John S., Seldin, Michael F., Ruiz, Phil, Alexander, Audrey A., Misukonis, Mary A., ...
Nitric oxide (NO) is an important mediator of the inflammatory response. MRL–lpr/lpr mice overexpress inducible nitric oxide synthase (NOS2) and overproduce NO in parallel with the development of...
Amos, Christopher I, Chen, Wei Vivien, Remmers, Elaine, Siminovitch, Katherine A, Seldin, Michael F, Criswell, Lindsey A, ...
For Genetic Analysis Workshop 15 Problem 2, we organized data from several ongoing studies designed to identify genetic and environmental risk factors for rheumatoid arthritis. Data were derived from...
Lee, Hye-Soon, Lee, Annette T, Criswell, Lindsey A, Seldin, Michael F, Amos, Christopher I, Carulli, John P, ...
Recent evidence suggests that additional risk loci for RA are present in the major histocompatibility complex (MHC), independent of the class II HLA-DRB1 locus. We have now tested a total of 1,769...
Taylor, Kimberly E., Remmers, Elaine F., Lee, Annette T., Ortmann, Ward A., Plenge, Robert M., Tian, Chao, ...
Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently been established as a risk factor for...
A Large-Scale Rheumatoid Arthritis Genetic Study Identifies Association at Chromosome 9q33.2
Chang, Monica, Rowland, Charles M., Garcia, Veronica E., Schrodi, Steven J., Catanese, Joseph J., ...
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease affecting both joints and extra-articular tissues. Although some genetic risk factors for RA are well-established, most notably...
Analysis of East Asia Genetic Substructure Using Genome-Wide SNP Arrays
Tian, Chao, Kosoy, Roman, Lee, Annette, Ransom, Michael, Belmont, John W., Gregersen, Peter K., ...
Accounting for population genetic substructure is important in reducing type 1 errors in genetic studies of complex disease. As efforts to understand complex genetic disease are expanded to different...
Barcellos, Lisa F., May, Suzanne L., Ramsay, Patricia P., Quach, Hong L., Lane, Julie A., Nititham, Joanne, ...
A substantial genetic contribution to systemic lupus erythematosus (SLE) risk is conferred by major histocompatibility complex (MHC) gene(s) on chromosome 6p21. Previous studies in SLE have lacked...
Aldrich, Melinda C., Selvin, Steve, Hansen, Helen M., Barcellos, Lisa F., Wrensch, Margaret R., Sison, Jennette D., ...
A variety of methods are available for estimating genetic admixture proportions in populations; however, few investigators have conducted detailed comparisons using empirical data. The authors...
Tian, Chao, Kosoy, Roman, Nassir, Rami, Lee, Annette, Villoslada, Pablo, Klareskog, Lars, ...
The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4,000 subjects...