Michael Freitag

Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa (2009)

Lewis, Zachary A., Honda, Shinji, Khlafallah, Tamir K., Jeffress, Jennifer K., Freitag, Michael, Mohn, Fabio, ...

Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and...

The fungus Neurospora crassadisplays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9 (2008)

Smith, Kristina M, Kothe, Gregory O, Matsen, Cindy B, Khlafallah, Tamir K, Adhvaryu, Keyur K, Hemphill, Melissa, ...

Abstract Background Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa , a...

Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae (2005)

Galagan, James E., Calvo, Sarah E., Cuomo, Christina, Ma, Li-Jun, Wortman, Jennifer R., Batzoglou, Serafim, ...

The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a...

El naufragio de la universidad y otros ensayos de epistemología política (2004)

Freitag, Michael

Traducción de: Le naufrage de l'Université et autres essais d'epistémologie politique

The methylated component of the Neurospora crassa genome (2003)

Selker, Eric U, Tountas, Nikolaos A, Cross, Sally H, Margolin, Brian S, Murphy, Jonathan G, Bird, Adrian P, ...

Cytosine methylation is common, but not ubiquitous, in eukaryotes. Mammals (1) and the fungus Neurospora crassa (2,3) have about 2–3% of cytosines methylated. In mammals, methylation is almost...

The methylated component of the Neurospora crassa genome (2003)

Selker, Eric U, Tountas, Nikolaos A, Cross, Sally H, Margolin, Brian S, Murphy, Jonathan G, Bird, Adrian P, ...

Cytosine methylation is common, but not ubiquitous, in eukaryotes. Mammals (1) and the fungus Neurospora crassa (2,3) have about 2–3% of cytosines methylated. In mammals, methylation is almost...

A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa

Freitag, Michael, Williams, Rebecca L., Kothe, Gregory O., Selker, Eric U.

During sexual development, Neurospora crassa inactivates genes in duplicated DNA segments by a hypermutation process, repeat-induced point mutation (RIP). RIP introduces C:G to T:A transition...

Induction and maintenance of nonsymmetrical DNA methylation in Neurospora

Selker, Eric U., Freitag, Michael, Kothe, Gregory O., Margolin, Brian S., Rountree, Michael R., Allis, C. David, ...

One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that...

Histone H1 Is Required for Proper Regulation of Pyruvate Decarboxylase Gene Expression in Neurospora crassa

Folco, H. Diego, Freitag, Michael, Ramón, Ana, Temporini, Esteban D., Alvarez, María E., García, Irene, ...

We show that Neurospora crassa has a single histone H1 gene, hH1, which encodes a typical linker histone with highly basic N- and C-terminal tails and a central globular domain. A green fluorescent...

Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism

Borkovich, Katherine A., Alex, Lisa A., Yarden, Oded, Freitag, Michael, Turner, Gloria E., Read, Nick D., ...

We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics and...

The Neurospora crassa White Collar-1 dependent Blue Light Response Requires Acetylation of Histone H3 Lysine 14 by NGF-1

Grimaldi, Benedetto, Coiro, Pierluca, Filetici, Patrizia, Berge, Emanuela, Dobosy, Joseph R., Freitag, Michael, ...

Blue light-induced transcription in Neurospora crassa is regulated by the White Collar-1 (WC-1) photoreceptor. We report that residue K14 of histone H3 associated with the light-inducible albino-3...

A cytosine methyltransferase homologue is essential for repeat-induced point mutation in Neurospora crassa

Freitag, Michael, Williams, Rebecca L., Kothe, Gregory O., Selker, Eric U.

During sexual development, Neurospora crassa inactivates genes in duplicated DNA segments by a hypermutation process, repeat-induced point mutation (RIP). RIP introduces C:G to T:A transition...

Induction and maintenance of nonsymmetrical DNA methylation in Neurospora

Selker, Eric U., Freitag, Michael, Kothe, Gregory O., Margolin, Brian S., Rountree, Michael R., Allis, C. David, ...

One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that...

Histone H1 Is Required for Proper Regulation of Pyruvate Decarboxylase Gene Expression in Neurospora crassa

Folco, H. Diego, Freitag, Michael, Ramón, Ana, Temporini, Esteban D., Alvarez, María E., García, Irene, ...

We show that Neurospora crassa has a single histone H1 gene, hH1, which encodes a typical linker histone with highly basic N- and C-terminal tails and a central globular domain. A green fluorescent...

Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism

Borkovich, Katherine A., Alex, Lisa A., Yarden, Oded, Freitag, Michael, Turner, Gloria E., Read, Nick D., ...

We present an analysis of over 1,100 of the ∼10,000 predicted proteins encoded by the genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of Neurospora genomics and...

The Neurospora crassa White Collar-1 dependent Blue Light Response Requires Acetylation of Histone H3 Lysine 14 by NGF-1

Grimaldi, Benedetto, Coiro, Pierluca, Filetici, Patrizia, Berge, Emanuela, Dobosy, Joseph R., Freitag, Michael, ...

Blue light-induced transcription in Neurospora crassa is regulated by the White Collar-1 (WC-1) photoreceptor. We report that residue K14 of histone H3 associated with the light-inducible albino-3...

Recurrent Locus-Specific Mutation Resulting From a Cryptic Ectopic Insertion in Neurospora

Perkins, David D., Freitag, Michael, Pollard, Virginia C., Bailey-Shrode, Lori A., Selker, Eric U., Ebbole, Daniel J.

New mutations are found among ∼20% of progeny when one or both parents carry eas allele UCLA191 (easUCLA, easily wettable, hydrophobin-deficient, linkage group II). The mutations inactivate the...

Spitzenkörper Localization and Intracellular Traffic of Green Fluorescent Protein-Labeled CHS-3 and CHS-6 Chitin Synthases in Living Hyphae of Neurospora crassa▿ †

Riquelme, Meritxell, Bartnicki-García, Salomon, González-Prieto, Juan Manuel, Sánchez-León, Eddy, Verdín-Ramos, Jorge A., Beltrán-Aguilar, Alejandro, ...

The subcellular location and traffic of two selected chitin synthases (CHS) from Neurospora crassa, CHS-3 and CHS-6, labeled with green fluorescent protein (GFP), were studied by high-resolution...

The Genome of Nectria haematococca: Contribution of Supernumerary Chromosomes to Gene Expansion

Coleman, Jeffrey J., Rounsley, Steve D., Rodriguez-Carres, Marianela, Kuo, Alan, Wasmann, Catherine C., Grimwood, Jane, ...

The ascomycetous fungus Nectria haematococca, (asexual name Fusarium solani), is a member of a group of >50 species known as the “Fusarium solani species complex”. Members of this complex have...

Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa

Lewis, Zachary A., Honda, Shinji, Khlafallah, Tamir K., Jeffress, Jennifer K., Freitag, Michael, Mohn, Fabio, ...

Both RNAi-dependent and -independent mechanisms have been implicated in the establishment of heterochromatin domains, which may be stabilized by feedback loops involving chromatin proteins and...