Ghisletti, Serena, Huang, Wendy, Jepsen, Kristen, Benner, Chris, Hardiman, Gary, Rosenfeld, Michael G., ...
Innate immune responses to bacterial or viral infection require rapid transition of large cohorts of inflammatory response genes from poised/repressed to actively transcribed states, but the...
Cooperative regulation in development by SMRT and FOXP1. (2008)
Jepsen, Kristen, Gleiberman, Anatoli S., Shi, Can, Simon, Daniel I., Rosenfeld, Michael G.
A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination...
Epigenetic regulation of stem cell fate (2008)
Lunyak, Victoria V., Rosenfeld, Michael G.
Stem cell-based regenerative medicine holds great promise for repair of diseased tissue. Modern directions in the field of epigenetic research aimed to decipher the epigenetic signals that give stem...
Lunyak, Victoria V., Prefontaine, Gratien G., Núñez, Esperanza, Cramer, Thorsten, Ju, Bong-Gun, Ohgi, Kenneth A., ...
4 pages, 4 figures.-- PMID: 17626886 [PubMed].-- Supporting Online Material (Materials and Methods; Figs. S1 to S4; Tables S1 and S2) available at:...
Rosenfeld, Michael G., Lunyak, Victoria V., Glass, Christopher K.
A decade of intensive investigation of coactivators and corepressors required for regulated actions of DNA-binding transcription factors has revealed a network of sequentially exchanged cofactor...
Zhu, Xiaoyan, Zhang, Jie, Tollkuhn, Jessica, Ohsawa, Ryosuke, Bresnick, Emery H., Guillemot, François, ...
Mammalian organogenesis results from the concerted actions of signaling pathways in progenitor cells that induce a hierarchy of regulated transcription factors critical for organ and cell type...
Direct isolation and identification of promoters in the human genome (2005)
Kim, Tae Hoon, Barrera, Leah O., Qu, Chunxu, Van Calcar, Sara, Trinklein, Nathan D., Cooper, Sara J., ...
Transcriptional regulatory elements play essential roles in gene expression during animal development and cellular response to environmental signals, but our knowledge of these regions in the human...
Direct isolation and identification of promoters in the human genome (2005)
Kim, Tae Hoon, Barrera, Leah O., Qu, Chunxu, Van Calcar, Sara, Trinklein, Nathan D., Cooper, Sara J., ...
Transcriptional regulatory elements play essential roles in gene expression during animal development and cellular response to environmental signals, but our knowledge of these regions in the human...
Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...
The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...
Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...
The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of 20 genes deleted in a heterozygous fashion in Miller–Dieker syndrome (MDS), a contiguous gene...
Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...
The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...
Corepressor-dependent silencing of chromosomal regions encoding neuronal genes (2002)
Victoria V. Lunyak, Et Al, Victoria V. Lunyak, Robert Burgess, Gratien G. Prefontaine, Charles Nelson, ...
The following resources related to this article are available online at
Corepressor-dependent silencing of chromosomal regions encoding neuronal genes (2002)
Victoria V. Lunyak, Robert Burgess, Gratien G. Prefontaine, Charles Nelson, Sing-hoi Sze, Josh Chenoweth, ...
The molecular mechanisms by which central nervous system–specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and...
Dasen, Jeremy S., Barbera, Juan-Pedro Martinez, Herman, Thomas S., Connell, Shawn O', Olson, Lorin, Ju, BongGun, ...
Murata, Takashi, Kurokawa, Riki, Krones, Anna, Tatsumi, Ken, Ishii, Masami, Taki, Tomohiko, ...
CREB-binding protein (CBP) is a transcriptional coactivator that has intrinsic histone acetyltransferase (HAT) activity. CBP is the causative gene of Rubinstein–Taybi syndrome (RTS). To investigate...
Molecular determinants of nuclear receptor-corepressor interaction (1999)
Perissi, Valentina, Staszewski, Lena M., McInerney, Eileen M., Kurokawa, Riki, Krones, Anna, Rose, David W., ...
Szeto, Daniel P., Rodriguez-Esteban, Concepción, Ryan, Aimee K., O'Connell, Shawn M., Liu, Forrest, Kioussi, Chrissa, ...
Understanding the molecular basis of breast carcinoma is central to designing rational and effective therapy for this prevalent disease. We have proposed to investigate several regulatory proteins...
Understanding the molecular basis of breast carcinoma is central to designing rational and effective therapy for this prevalent disease. We have proposed to investigate several regulatory proteins...
Molecular Mechanisms of Glial Abnormalities in Neurofibromatosis (1998)
Neurofibromatosis is a genetic disease in which the major pathology is due to abnormal proliferation of Schwann cells. One of the two tumor suppressor genes mutated in this disease is the...
Molecular Mechanisms of Glial Abnormalitites in Neurofibromatosis (1998)
Schwann cells proliferation appears to be controlled by cAMP, implicating CREB, and the CREB-binding protein. CBP specifically modulate cAMP and ras-dependent growth events in glia. This is likely to...
The Role of N-CoR During Normal Mammary Gland Development (1998)
Bong-Gun, Ju, Rosenfeld, Michael G.
Recently, coactivator and corepressor complexes required for function of estrogen receptor (ER), and other nuclear receptors, have been identified, with critical implications for aspects of etiology...
The Role of N-CoR During Normal Mammary Gland Development (1998)
Ju, Bong-Gun, Rosenfeld, Michael G.
Understanding the regulation of N-CoR and its associated corepressors, in concert with defining the molecular mechanisms that underlie regulation by estrogen- receptor, offers a reasonable prospect...
The Role of N-Cor During Normal Mammary Gland Development (1998)
Ju, Bong-Gun, Rosenfeld, Michael G.
Understanding the regulation of N-CoR and its associated co-repressors, in concert with defining the molecular mechanisms that underlie regulation by estrogen receptors, offers a reasonable prospect...
McInerney, Eileen M., Rose, David W., Flynn, Sarah E., Westin, Stefan, Mullen, Tina-Marie, Krones, Anna, ...
Multistep signaling requirements for pituitary organogenesis in vivo (1998)
Treier, Mathias, Gleiberman, Anatoli S., O'Connell, Shawn M., Szeto, Daniel P., McMahon, Jill A., McMahon, Andrew P., ...
Understanding the molecular basis of breast carcinoma is central to designing rational and effective therapy for this prevalent disease. We have proposed to investigate several regulatory proteins...
Understanding the molecular basis of breast carcinoma is central to designing rational and effective therapy for this prevalent disease.
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Yu-Der, Perissi, Valentina, Staszewski, Lena M., Yang, Wen-Ming, Krones, Anna, Glass, Christopher K., ...
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase...
Regulation of somatic growth by the p160 coactivator p/CIP
Wang, Zhiyong, Rose, David W., Hermanson, Ola, Liu, Forrest, Herman, Thomas, Wu, Wei, ...
A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to...
Llopis, Juan, Westin, Stefan, Ricote, Mercedes, Wang, Jiahong, Cho, Charles Y., Kurokawa, Riki, ...
Members of the nuclear receptor superfamily are thought to activate transcription by recruitment of one or more recently identified coactivator complexes. Here we demonstrate that both peroxisome...
A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1
Kurahashi, Yuko, Herbertsson, Helena, Söderström, Mats, Rosenfeld, Michael G., Hammarström, Sven
Lewis lung carcinoma cells contain specific high-affinity binding sites for the eicosanoid 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid [12(S)-HETE]. These binding sites have a cytosolic/nuclear...
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
Lavinsky, Robert M., Jepsen, Kristen, Heinzel, Thorsten, Torchia, Joseph, Mullen, Tina-Marie, Schiff, Rachel, ...
Several lines of evidence indicate that the nuclear receptor corepressor (N-CoR) complex imposes ligand dependence on transcriptional activation by the retinoic acid receptor and mediates the...
Factor-specific modulation of CREB-binding protein acetyltransferase activity
Perissi, Valentina, Dasen, Jeremy S., Kurokawa, Riki, Wang, Zhiyong, Korzus, Edward, Rose, David W., ...
CREB-binding proteins (CBP) and p300 are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, including CREB, nuclear receptors, and STATs. CBP...
Reduced fertility in mice deficient for the POU protein sperm-1
Pearse, Richard V., Drolet, Daniel W., Kalla, Kristin A., Hooshmand, Farideh, Bermingham, John R., Rosenfeld, Michael G.
Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain...
Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
Kioussi, Chrissa, O’Connell, Shawn, St-Onge, Luc, Treier, Mathias, Gleiberman, Anatoli S., Gruss, Peter, ...
Pax6, a highly conserved member of the paired homeodomain transcription factor family that plays essential roles in ocular, neural, and pancreatic development and effects asymmetric transient dorsal...
Control of alternative pre-mRNA splicing by distributed pentameric repeats
Hedjran, Farah, Yeakley, Joanne M., Huh, Gene S., Hynes, Richard O., Rosenfeld, Michael G.
Multiple copies of the hexamer TGCATG have been shown to regulate fibronectin pre-mRNA alternative splicing. GCATG repeats also are clustered near the regulated calcitonin-specific 3′ splice site...
Zamir, Iris, Dawson, Jessica, Lavinsky, Robert M., Glass, Christopher K., Rosenfeld, Michael G., Lazar, Mitchell A.
Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear...
Rühmann, Andreas, Bonk, Ines, Lin, Chijen R., Rosenfeld, Michael G., Spiess, Joachim
Different truncated and conformationally constrained analogs of corticotropin-releasing factor (CRF) were synthesized on the basis of the amino acid sequences of human/rat CRF (h/rCRF), ovine CRF...
Sugihara, Tod M., Bach, Ingolf, Kioussi, Chrissa, Rosenfeld, Michael G., Andersen, Bogi
Nuclear LIM domains interact with a family of coregulators referred to as Clim/Ldb/Nli. Although one family member, Clim-2/Ldb-1/Nli, is highly expressed in epidermal keratinocytes, no nuclear LIM...
Tbx19, a tissue-selective regulator of POMC gene expression
Liu, Jianxiang, Lin, Chijen, Gleiberman, Anatoli, Ohgi, Kenneth A., Herman, Thomas, Huang, Hsiang-Po, ...
Pituitary cell types arise in a temporally and spatially specific fashion, in response to combinatorial actions of transcription factors induced by transient signaling gradients. The critical...
Transcriptional Activation by NF-κB Requires Multiple Coactivators
Sheppard, Kelly-Ann, Rose, David W., Haque, Zaffar K., Kurokawa, Riki, McInerney, Eileen, Westin, Stefan, ...
Nuclear factor-κB (NF-κB) plays a role in the transcriptional regulation of genes involved in inflammation and cell survival. In this report we demonstrate that NF-κB recruits a coactivator...
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
Lutterbach, Bart, Westendorf, Jennifer J., Linggi, Bryan, Patten, Andrea, Moniwa, Mariko, Davie, James R., ...
t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric protein, acute myeloid leukemia-1 (AML-1)–eight-twenty-one (ETO), that contains the...
Beischlag, Timothy V., Wang, Song, Rose, David W., Torchia, Joseph, Reisz-Porszasz, Suzanne, Muhammad, Khurshid, ...
The aryl hydrocarbon receptor complex heterodimeric transcription factor, comprising the basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain aryl hydrocarbon receptor (AHR) and aryl hydrocarbon...
Evidence for vestibular regulation of autonomic functions in a mouse genetic model
Murakami, Dean M., Erkman, Linda, Hermanson, Ola, Rosenfeld, Michael G., Fuller, Charles A.
Physiological responses to changes in the gravitational field and body position, as well as symptoms of patients with anxiety-related disorders, have indicated an interrelationship between vestibular...
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
Baek, Sung Hee, Kioussi, Chrissa, Briata, Paola, Wang, Degeng, Nguyen, H. D., Ohgi, Kenneth A., ...
Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2. Here, we report that...
Wagner, Brandee L., Valledor, Annabel F., Shao, Gang, Daige, Chris L., Bischoff, Eric D., Petrowski, Mary, ...
Liver X receptors (LXRs) regulate the expression of genes involved in cholesterol and fatty acid homeostasis, including the genes for ATP-binding cassette transporter A1 (ABCA1) and sterol response...
Szeto, Daniel P., Rodriguez-Esteban, Concepción, Ryan, Aimee K., O’Connell, Shawn M., Liu, Forrest, Kioussi, Chrissa, ...
Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary gland and first branchial arch. Here, we...
Multistep signaling requirements for pituitary organogenesis in vivo
Treier, Mathias, Gleiberman, Anatoli S., O’Connell, Shawn M., Szeto, Daniel P., McMahon, Jill A., McMahon, Andrew P., ...
During development of the mammalian pituitary gland specific hormone-producing cell types, critical in maintaining homeostasis, emerge in a spatially and temporally specific fashion from an...
Molecular determinants of nuclear receptor–corepressor interaction
Perissi, Valentina, Staszewski, Lena M., McInerney, Eileen M., Kurokawa, Riki, Krones, Anna, Rose, David W., ...
Retinoic acid and thyroid hormone receptors can act alternatively as ligand-independent repressors or ligand-dependent activators, based on an exchange of N-CoR or SMRT-containing corepressor...
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
McInerney, Eileen M., Rose, David W., Flynn, Sarah E., Westin, Stefan, Mullen, Tina-Marie, Krones, Anna, ...
Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three...
Control of Transcription of RNA Rich in Polyadenylic Acid in Human Lymphocytes
Rosenfeld, Michael G., Abrass, Itamar B., Mendelsohn, John, Roos, Bernard A., Boone, Robert F., Garren, Leonard D.
Rapidly labeled polyribosomal RNA rich in poly(A) has been isolated from cultures of highly purified human peripheral blood lymphocytes. Messenger RNA function for this RNA is suggested by its...
Ogawa, Sumito, Lozach, Jean, Jepsen, Kristen, Sawka-Verhelle, Dominique, Perissi, Valentina, Sasik, Roman, ...
The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of multiprotein complexes that...
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
Olson, Lorin E., Zhang, Jie, Taylor, Havilah, Rose, David W., Rosenfeld, Michael G.
The hair-growth cycle, a complex biological system requiring coordinate alterations in gene expression and cellular behavior, provides a challenging model for investigating the interplay of specific...
Direct isolation and identification of promoters in the human genome
Kim, Tae Hoon, Barrera, Leah O., Qu, Chunxu, Van Calcar, Sara, Trinklein, Nathan D., Cooper, Sara J., ...
Transcriptional regulatory elements play essential roles in gene expression during animal development and cellular response to environmental signals, but our knowledge of these regions in the human...
Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET
Telese, Francesca, Bruni, Paola, Donizetti, Aldo, Gianni, Davide, D'Ambrosio, Chiara, Scaloni, Andrea, ...
Fe65 protein interacts with the cytosolic domain of the amyloid precursor APP. Its possible involvement in gene regulation is suggested by numerous observations, including those demonstrating that it...
Dasen, Jeremy S., Barbera, Juan-Pedro Martinez, Herman, Thomas S., Connell, Shawn O', Olson, Lorin, Ju, BongGun, ...
Understanding the functional significance of the coordinate expression of specific corepressors and DNA-binding transcription factors remains a critical question in mammalian development. During the...
Ogawa, Sumito, Lozach, Jean, Benner, Chris, Pascual, Gabriel, Tangirala, Rajendra K., Westin, Stefan, ...
The ability of nuclear receptors (NRs) to repress transcriptional responses to diverse signaling pathways is an essential aspect of their biological activities, but mechanisms determining the...
A sumoylation-dependent pathway mediating transrepression of inflammatory response genes by PPARγ
Pascual, Gabriel, Fong, Amy L., Ogawa, Sumito, Gamliel, Amir, Li, Andrew C., Perissi, Valentina, ...
The peroxisome proliferator-activated receptor γ (PPARγ) plays essential roles in adipogenesis and glucose homeostasis and is a molecular target of insulin-sensitizing drugs1–3. Although the...
Baek, Sung Hee, Ohgi, Kenneth A., Nelson, Charles A., Welsbie, Derek, Chen, Charlie, Sawyers, Charles L., ...
The androgen receptor not only mediates prostate development but also serves as a key regulator of primary prostatic cancer growth. Although initially responsive to selective androgen receptor...
The histone deacetylase-3 complex contains nuclear receptor corepressors
Wen, Yu-Der, Perissi, Valentina, Staszewski, Lena M., Yang, Wen-Ming, Krones, Anna, Glass, Christopher K., ...
Acetylation and deacetylation of nucleosomal histones have profound effects on gene transcription in all eukaryotes. In humans, three highly homologous class I and four class II histone deacetylase...
Regulation of somatic growth by the p160 coactivator p/CIP
Wang, Zhiyong, Rose, David W., Hermanson, Ola, Liu, Forrest, Herman, Thomas, Wu, Wei, ...
A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to...
Llopis, Juan, Westin, Stefan, Ricote, Mercedes, Wang, Jiahong, Cho, Charles Y., Kurokawa, Riki, ...
Members of the nuclear receptor superfamily are thought to activate transcription by recruitment of one or more recently identified coactivator complexes. Here we demonstrate that both peroxisome...
A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1
Kurahashi, Yuko, Herbertsson, Helena, Söderström, Mats, Rosenfeld, Michael G., Hammarström, Sven
Lewis lung carcinoma cells contain specific high-affinity binding sites for the eicosanoid 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid [12(S)-HETE]. These binding sites have a cytosolic/nuclear...
Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes
Lavinsky, Robert M., Jepsen, Kristen, Heinzel, Thorsten, Torchia, Joseph, Mullen, Tina-Marie, Schiff, Rachel, ...
Several lines of evidence indicate that the nuclear receptor corepressor (N-CoR) complex imposes ligand dependence on transcriptional activation by the retinoic acid receptor and mediates the...
Factor-specific modulation of CREB-binding protein acetyltransferase activity
Perissi, Valentina, Dasen, Jeremy S., Kurokawa, Riki, Wang, Zhiyong, Korzus, Edward, Rose, David W., ...
CREB-binding proteins (CBP) and p300 are essential transcriptional coactivators for a large number of regulated DNA-binding transcription factors, including CREB, nuclear receptors, and STATs. CBP...
Reduced fertility in mice deficient for the POU protein sperm-1
Pearse, Richard V., Drolet, Daniel W., Kalla, Kristin A., Hooshmand, Farideh, Bermingham, John R., Rosenfeld, Michael G.
Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain...
Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development
Kioussi, Chrissa, O’Connell, Shawn, St-Onge, Luc, Treier, Mathias, Gleiberman, Anatoli S., Gruss, Peter, ...
Pax6, a highly conserved member of the paired homeodomain transcription factor family that plays essential roles in ocular, neural, and pancreatic development and effects asymmetric transient dorsal...
Control of alternative pre-mRNA splicing by distributed pentameric repeats
Hedjran, Farah, Yeakley, Joanne M., Huh, Gene S., Hynes, Richard O., Rosenfeld, Michael G.
Multiple copies of the hexamer TGCATG have been shown to regulate fibronectin pre-mRNA alternative splicing. GCATG repeats also are clustered near the regulated calcitonin-specific 3′ splice site...
Zamir, Iris, Dawson, Jessica, Lavinsky, Robert M., Glass, Christopher K., Rosenfeld, Michael G., Lazar, Mitchell A.
Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear...
Rühmann, Andreas, Bonk, Ines, Lin, Chijen R., Rosenfeld, Michael G., Spiess, Joachim
Different truncated and conformationally constrained analogs of corticotropin-releasing factor (CRF) were synthesized on the basis of the amino acid sequences of human/rat CRF (h/rCRF), ovine CRF...
Sugihara, Tod M., Bach, Ingolf, Kioussi, Chrissa, Rosenfeld, Michael G., Andersen, Bogi
Nuclear LIM domains interact with a family of coregulators referred to as Clim/Ldb/Nli. Although one family member, Clim-2/Ldb-1/Nli, is highly expressed in epidermal keratinocytes, no nuclear LIM...
Tbx19, a tissue-selective regulator of POMC gene expression
Liu, Jianxiang, Lin, Chijen, Gleiberman, Anatoli, Ohgi, Kenneth A., Herman, Thomas, Huang, Hsiang-Po, ...
Pituitary cell types arise in a temporally and spatially specific fashion, in response to combinatorial actions of transcription factors induced by transient signaling gradients. The critical...
Transcriptional Activation by NF-κB Requires Multiple Coactivators
Sheppard, Kelly-Ann, Rose, David W., Haque, Zaffar K., Kurokawa, Riki, McInerney, Eileen, Westin, Stefan, ...
Nuclear factor-κB (NF-κB) plays a role in the transcriptional regulation of genes involved in inflammation and cell survival. In this report we demonstrate that NF-κB recruits a coactivator...
ETO, a Target of t(8;21) in Acute Leukemia, Interacts with the N-CoR and mSin3 Corepressors
Lutterbach, Bart, Westendorf, Jennifer J., Linggi, Bryan, Patten, Andrea, Moniwa, Mariko, Davie, James R., ...
t(8;21) is one of the most frequent translocations associated with acute myeloid leukemia. It produces a chimeric protein, acute myeloid leukemia-1 (AML-1)–eight-twenty-one (ETO), that contains the...
Beischlag, Timothy V., Wang, Song, Rose, David W., Torchia, Joseph, Reisz-Porszasz, Suzanne, Muhammad, Khurshid, ...
The aryl hydrocarbon receptor complex heterodimeric transcription factor, comprising the basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain aryl hydrocarbon receptor (AHR) and aryl hydrocarbon...
Evidence for vestibular regulation of autonomic functions in a mouse genetic model
Murakami, Dean M., Erkman, Linda, Hermanson, Ola, Rosenfeld, Michael G., Fuller, Charles A.
Physiological responses to changes in the gravitational field and body position, as well as symptoms of patients with anxiety-related disorders, have indicated an interrelationship between vestibular...
Regulated subset of G1 growth-control genes in response to derepression by the Wnt pathway
Baek, Sung Hee, Kioussi, Chrissa, Briata, Paola, Wang, Degeng, Nguyen, H. D., Ohgi, Kenneth A., ...
Pitx2 is a bicoid-related homeodomain factor that is required for effective cell type-specific proliferation directly activating a specific growth-regulating gene cyclin D2. Here, we report that...
Wagner, Brandee L., Valledor, Annabel F., Shao, Gang, Daige, Chris L., Bischoff, Eric D., Petrowski, Mary, ...
Liver X receptors (LXRs) regulate the expression of genes involved in cholesterol and fatty acid homeostasis, including the genes for ATP-binding cassette transporter A1 (ABCA1) and sterol response...
Dasen, Jeremy S., Barbera, Juan-Pedro Martinez, Herman, Thomas S., Connell, Shawn O', Olson, Lorin, Ju, BongGun, ...
Understanding the functional significance of the coordinate expression of specific corepressors and DNA-binding transcription factors remains a critical question in mammalian development. During the...
Szeto, Daniel P., Rodriguez-Esteban, Concepción, Ryan, Aimee K., O’Connell, Shawn M., Liu, Forrest, Kioussi, Chrissa, ...
Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary gland and first branchial arch. Here, we...
Multistep signaling requirements for pituitary organogenesis in vivo
Treier, Mathias, Gleiberman, Anatoli S., O’Connell, Shawn M., Szeto, Daniel P., McMahon, Jill A., McMahon, Andrew P., ...
During development of the mammalian pituitary gland specific hormone-producing cell types, critical in maintaining homeostasis, emerge in a spatially and temporally specific fashion from an...
Molecular determinants of nuclear receptor–corepressor interaction
Perissi, Valentina, Staszewski, Lena M., McInerney, Eileen M., Kurokawa, Riki, Krones, Anna, Rose, David W., ...
Retinoic acid and thyroid hormone receptors can act alternatively as ligand-independent repressors or ligand-dependent activators, based on an exchange of N-CoR or SMRT-containing corepressor...
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
McInerney, Eileen M., Rose, David W., Flynn, Sarah E., Westin, Stefan, Mullen, Tina-Marie, Krones, Anna, ...
Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three...
Control of Transcription of RNA Rich in Polyadenylic Acid in Human Lymphocytes
Rosenfeld, Michael G., Abrass, Itamar B., Mendelsohn, John, Roos, Bernard A., Boone, Robert F., Garren, Leonard D.
Rapidly labeled polyribosomal RNA rich in poly(A) has been isolated from cultures of highly purified human peripheral blood lymphocytes. Messenger RNA function for this RNA is suggested by its...
Ogawa, Sumito, Lozach, Jean, Jepsen, Kristen, Sawka-Verhelle, Dominique, Perissi, Valentina, Sasik, Roman, ...
The nuclear receptor corepressor (NCoR) and the related factor known as silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of multiprotein complexes that...
Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling
Olson, Lorin E., Zhang, Jie, Taylor, Havilah, Rose, David W., Rosenfeld, Michael G.
The hair-growth cycle, a complex biological system requiring coordinate alterations in gene expression and cellular behavior, provides a challenging model for investigating the interplay of specific...
Direct isolation and identification of promoters in the human genome
Kim, Tae Hoon, Barrera, Leah O., Qu, Chunxu, Van Calcar, Sara, Trinklein, Nathan D., Cooper, Sara J., ...
Transcriptional regulatory elements play essential roles in gene expression during animal development and cellular response to environmental signals, but our knowledge of these regions in the human...
Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET
Telese, Francesca, Bruni, Paola, Donizetti, Aldo, Gianni, Davide, D'Ambrosio, Chiara, Scaloni, Andrea, ...
Fe65 protein interacts with the cytosolic domain of the amyloid precursor APP. Its possible involvement in gene regulation is suggested by numerous observations, including those demonstrating that it...
Baek, Sung Hee, Ohgi, Kenneth A., Nelson, Charles A., Welsbie, Derek, Chen, Charlie, Sawyers, Charles L., ...
The androgen receptor not only mediates prostate development but also serves as a key regulator of primary prostatic cancer growth. Although initially responsive to selective androgen receptor...
Zhu, Xiaoyan, Zhang, Jie, Tollkuhn, Jessica, Ohsawa, Ryosuke, Bresnick, Emery H., Guillemot, François, ...
Mammalian organogenesis results from the concerted actions of signaling pathways in progenitor cells that induce a hierarchy of regulated transcription factors critical for organ and cell type...
Kwon, Young-Soo, Garcia-Bassets, Ivan, Hutt, Kasey R., Cheng, Christine S., Jin, Mingjie, Liu, Dongyan, ...
ChIP coupled with microarray provides a powerful tool to determine in vivo binding profiling of transcription factors to deduce regulatory circuitries in mammalian cells. Aiming at improving the...
Lin, Lizhu, Cui, Li, Zhou, Wenlai, Dufort, Daniel, Zhang, Xiaoxue, Cai, Chen-Leng, ...
Recent studies have demonstrated that the LIM homeodomain transcription factor Islet1 (Isl1) marks pluripotent cardiovascular progenitor cells and is required for proliferation, survival, and...
Xiao, Ran, Sun, Ye, Ding, Jian-Hua, Lin, Shengrong, Rose, Dave W., Rosenfeld, Michael G., ...
The members of the SR family of splicing regulators were initially characterized for their critical roles in constitutive and regulated splicing. They are implicated in different aspects of gene...
Atbf1 is required for the Pit1 gene early activation
Qi, Yingchuan, Ranish, Jeffrey A., Zhu, Xiaoyan, Krones, Anna, Zhang, Jie, Aebersold, Ruedi, ...
Enhancers have been functionally described for >35 years, but the molecular principles underlying the integration of regulatory inputs to alternate gene enhancers used during mammalian organogenesis...
Cooperative regulation in development by SMRT and FOXP1
Jepsen, Kristen, Gleiberman, Anatoli S., Shi, Can, Simon, Daniel I., Rosenfeld, Michael G.
A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination...
Genetic approaches identify adult pituitary stem cells
Gleiberman, Anatoli S., Michurina, Tatyana, Encinas, Juan M., Roig, Jose L., Krasnov, Peter, Balordi, Francesca, ...
Adult tissues undergo continuous cell turnover in response to stress, damage, or physiological demand. New differentiated cells are generated from dedicated or facultative stem cells or from...
Hu, Qidong, Kwon, Young-Soo, Nunez, Esperanza, Cardamone, Maria Dafne, Hutt, Kasey R., Ohgi, Kenneth A., ...
Although the role of liganded nuclear receptors in mediating coactivator/corepressor exchange is well-established, little is known about the potential regulation of chromosomal organization in the...
Li, Hairi, Lovci, Michael T., Kwon, Young-Soo, Rosenfeld, Michael G., Fu, Xiang-Dong, Yeo, Gene W.
High-throughput sequencing has rapidly gained popularity for transcriptome analysis in mammalian cells because of its ability to generate digital and quantitative information on annotated genes and...
Cardamone, Maria Dafne, Bardella, Chiara, Gutierrez, Arantxa, Di Croce, Luciano, Rosenfeld, Michael G., Di Renzo, Maria Flavia, ...
Estrogen receptor α (ERα) and E-cadherin are primary markers of luminal epithelial breast cancer cells with E-cadherin being a main caretaker of the epithelial phenotype. E-cadherin repression is...
Ghisletti, Serena, Huang, Wendy, Jepsen, Kristen, Benner, Chris, Hardiman, Gary, Rosenfeld, Michael G., ...
Innate immune responses to bacterial or viral infection require rapid transition of large cohorts of inflammatory response genes from poised/repressed to actively transcribed states, but the...