Noyes, Marcus B., Christensen, Ryan G., Wakabayashi, Atsuya, Stormo, Gary D., Brodsky, Michael H., Wolfe, Scot A.
We describe the comprehensive characterization of homeodomain DNA-binding specificities from a metazoan genome. The analysis of all 84 independent homeodomains from D. melanogaster reveals the...
Noyes, Marcus B., Meng, Xiangdong, Wakabayashi, Atsuya, Sinha, Saurabh, Brodsky, Michael H., Wolfe, Scot A.
Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis-regulatory modules in a genome. The primary...
Noyes, Marcus B., Meng, Xiangdong, Wakabayashi, Atsuya, Sinha, Saurabh, Brodsky, Michael H., Wolfe, Scot A.
Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis-regulatory modules in a genome. The primary...
Quantitative analysis of Hedgehog gradient formation using an inducible expression system (2007)
Su, Vivian F., Jones, Kelly A., Brodsky, Michael H., The, Inge
BACKGROUND: The Hedgehog (Hh) family of secreted growth factors are morphogens that act in development to direct growth and patterning. Mutations in human Hh and other Hh pathway components have been...
Epigenetic telomere protection by Drosophila DNA damage response pathways (2006)
Oikemus, Sarah R., Queiroz-Machado, Joana, Lai, KuanJu, McGinnis-Schultz, Nadine, Sunkel, Claudio E., Brodsky, Michael H.
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...
Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways (2006)
Sarah R. Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine McGinnis, Claudio Sunkel, Michael H. Brodsky
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...
Epigenetic telomere protection by Drosophila DNA damage response pathways (2006)
Sarah R Oikemus, Joana Queiroz-Machado, KuanJu Lai, Nadine M McGinnis, Claudio E. Sunkel, Michael H Brodsky
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...
Meng, Xiangdong, Brodsky, Michael H., Wolfe, Scot A.
The DNA-binding specificities of transcription factors can be used to computationally predict cis-regulatory modules (CRMs) that regulate gene expression. However, the absence of specificity data for...
Oikemus, Sarah R., McGinnis-Schultz, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., Schultz, Nadine, Golic, Kent G., ...
We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent...
Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development (2000)
Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.
mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.
Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...
Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., McGinnis, Nadine M., Golic, Kent G., ...
We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent...
Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors
Meng, Xiangdong, Brodsky, Michael H., Wolfe, Scot A.
The DNA-binding specificities of transcription factors can be used to computationally predict cis-regulatory modules (CRMs) that regulate gene expression1. However, the absence of specificity data...
Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
Oikemus, Sarah R, Queiroz-Machado, Joana, Lai, KuanJu, McGinnis, Nadine, Sunkel, Claudio, Brodsky, Michael H
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...
mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development
Brodsky, Michael H., Sekelsky, Jeff J., Tsang, Garson, Hawley, R. Scott, Rubin, Gerald M.
Checkpoints block cell cycle progression in eukaryotic cells exposed to DNA damaging agents. We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3ε, regulate a DNA...
Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., McGinnis, Nadine M., Golic, Kent G., ...
We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent...
Oikemus, Sarah R., McGinnis, Nadine, Queiroz-Machado, Joana, Tukachinsky, Hanna, Takada, Saeko, Sunkel, Claudio E., ...
Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these...
Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
Oikemus, Sarah R, Queiroz-Machado, Joana, Lai, KuanJu, McGinnis, Nadine, Sunkel, Claudio, Brodsky, Michael H
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as...
Noyes, Marcus B., Meng, Xiangdong, Wakabayashi, Atsuya, Sinha, Saurabh, Brodsky, Michael H., Wolfe, Scot A.
Specificity data for groups of transcription factors (TFs) in a common regulatory network can be used to computationally identify the location of cis-regulatory modules in a genome. The primary...
p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy
McNamee, Laura M., Brodsky, Michael H.
DNA damage or unprotected telomeres can trigger apoptosis via signaling pathways that directly sense abnormal DNA structures and activate the p53 transcription factor. We describe a p53-independent...