Genetic Analysis of Human Breast Cancer. (1998)
Wigler, Michael H., Lisitsyn, Nikolia
Cancer is a disorder brought upon by the accumulation of specific mutations in the cancerous cells. Our understanding of the disease, and potentially its diagnosis and therapeutic treatment, is...
Genetic Analysis of Human Breast Cancer (1998)
The genetic abnormalities that accumulate in tumor cells are potential clues to their evolution. To identify such abnormalities, we have developed RDA (representational difference analysis), a method...
High Resolution Analysis of Copy Number Mutation in Breast Cancer (1998)
Cancer is a disease associated with both germline and somatic mutation, and undoubtedly evolves in the host through increasingly malignant states by changes in the genome. Many of these changes can...
Genetic Analysis of Human Breast Cancer. (1997)
Cancer is a disorder brought upon by the accumulation of specific mutations in the cancerous cells. Our understanding of the disease, and potentially its diagnosis and therapeutic treatment, is...
Nucleosomes in metaphase chromosomes (1976)
Wigler, Michael H., Axel, Richard
Previous studies of the structure of metaphase chromosomes have relied heavily on electron micrography and have revealed the existence of a 10-nm unit fiber that is thought to generate the native...
Rapid isolation of cDNA by hybridization
Hamaguchi, Masaaki, O’Connor, Elizabeth A., Chen, Tong, Parnell, Larry, McCombie, Richard W., Wigler, Michael H.
The isolation of genes from a given genomic region can be a rate-limiting step in the discovery of disease genes. We describe an approach to the isolation of cDNAs that have sequences in common with...
Signaling pathways in Ras-mediated tumorigenicity and metastasis
Webb, Craig P., Van Aelst, Linda, Wigler, Michael H., Vande Woude, George F.
The effector domain mutants of oncogenic Ras, V12S35 Ras, V12G37 Ras, and V12C40 Ras were tested for their abilities to mediate tumorigenic and metastatic phenotypes in athymic nude mice when...
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, Michael P., Stolarov, Javor P., Eng, Charis, Li, Jing, Wang, Steven I., Wigler, Michael H., ...
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate...
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
Myers, Michael P., Pass, Ian, Batty, Ian H., Van Der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., ...
Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their ability to antagonize the growth-promoting protein tyrosine kinases....
PTEN controls tumor-induced angiogenesis
Wen, Shenghua, Stolarov, Javor, Myers, Michael P., Su, Jing Dong, Wigler, Michael H., Tonks, Nicholas K., ...
Mutations of the tumor suppressor PTEN, a phosphatase with specificity for 3-phosphorylated inositol phospholipids, accompany progression of brain tumors from benign to the most malignant forms....
Stolarov, Javor, Chang, Kenneth, Reiner, Andrew, Rodgers, Linda, Hannon, Gregory J., Wigler, Michael H., ...
We have engineered the ecdysone-inducible mammalian expression system for general retroviral delivery to cultured mammalian cells. We inducibly expressed PTEN in the glioblastoma cell line, U87MG,...
DBC2, a candidate for a tumor suppressor gene involved in breast cancer
Hamaguchi, Masaaki, Meth, Jennifer L., Von Klitzing, Christine, Wei, Wen, Esposito, Diane, Rodgers, Linda, ...
A previously uncharacterized gene, DBC2 (deleted in breast cancer), was cloned from a homozygously deleted region at human chromosome 8p21. DBC2 contains a highly conserved RAS domain and two...
Rapid isolation of cDNA by hybridization
Hamaguchi, Masaaki, O’Connor, Elizabeth A., Chen, Tong, Parnell, Larry, McCombie, Richard W., Wigler, Michael H.
The isolation of genes from a given genomic region can be a rate-limiting step in the discovery of disease genes. We describe an approach to the isolation of cDNAs that have sequences in common with...
Signaling pathways in Ras-mediated tumorigenicity and metastasis
Webb, Craig P., Van Aelst, Linda, Wigler, Michael H., Vande Woude, George F.
The effector domain mutants of oncogenic Ras, V12S35 Ras, V12G37 Ras, and V12C40 Ras were tested for their abilities to mediate tumorigenic and metastatic phenotypes in athymic nude mice when...
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, Michael P., Stolarov, Javor P., Eng, Charis, Li, Jing, Wang, Steven I., Wigler, Michael H., ...
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate...
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
Myers, Michael P., Pass, Ian, Batty, Ian H., Van Der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., ...
Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their ability to antagonize the growth-promoting protein tyrosine kinases....
PTEN controls tumor-induced angiogenesis
Wen, Shenghua, Stolarov, Javor, Myers, Michael P., Su, Jing Dong, Wigler, Michael H., Tonks, Nicholas K., ...
Mutations of the tumor suppressor PTEN, a phosphatase with specificity for 3-phosphorylated inositol phospholipids, accompany progression of brain tumors from benign to the most malignant forms....
Stolarov, Javor, Chang, Kenneth, Reiner, Andrew, Rodgers, Linda, Hannon, Gregory J., Wigler, Michael H., ...
We have engineered the ecdysone-inducible mammalian expression system for general retroviral delivery to cultured mammalian cells. We inducibly expressed PTEN in the glioblastoma cell line, U87MG,...
DBC2, a candidate for a tumor suppressor gene involved in breast cancer
Hamaguchi, Masaaki, Meth, Jennifer L., Von Klitzing, Christine, Wei, Wen, Esposito, Diane, Rodgers, Linda, ...
A previously uncharacterized gene, DBC2 (deleted in breast cancer), was cloned from a homozygously deleted region at human chromosome 8p21. DBC2 contains a highly conserved RAS domain and two...