Michael J. Cieslewicz

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

Malley, Richard, Henneke, Philipp, Morse, Sarah C., Cieslewicz, Michael J., Lipsitch, Marc, Thompson, Claudette M., ...

Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contribute...

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, Xiaoming, Gao, Junjun, Jain, Chaitanya, Cieslewicz, Michael J., Swartz, James R., Georgiou, George

We designed a selection strategy for the isolation of Escherichia coli mutants exhibiting enhanced protein disulfide isomerase activity. The folding of a variant of tissue plasminogen activator...

Regulation of Virulence by a Two-Component System in Group B Streptococcus†

Jiang, Sheng-Mei, Cieslewicz, Michael J., Kasper, Dennis L., Wessels, Michael R.

Group B Streptococcus (GBS) is frequently carried in the gastrointestinal or genitourinary tract as a commensal organism, yet it has the potential to cause life-threatening infection in newborn...

Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides

Cieslewicz, Michael J., Chaffin, Donald, Glusman, Gustavo, Kasper, Dennis, Madan, Anup, Rodrigues, Stephani, ...

Group B Streptococcus (GBS) is an important pathogen of neonates, pregnant women, and immunocompromised individuals. GBS isolates associated with human infection produce one of nine antigenically...

Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome”

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...

The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...

Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....

Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection

Malley, Richard, Henneke, Philipp, Morse, Sarah C., Cieslewicz, Michael J., Lipsitch, Marc, Thompson, Claudette M., ...

Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contribute...

Genetic Analysis of Disulfide Isomerization in Escherichia coli: Expression of DsbC Is Modulated by RNase E-Dependent mRNA Processing

Zhan, Xiaoming, Gao, Junjun, Jain, Chaitanya, Cieslewicz, Michael J., Swartz, James R., Georgiou, George

We designed a selection strategy for the isolation of Escherichia coli mutants exhibiting enhanced protein disulfide isomerase activity. The folding of a variant of tissue plasminogen activator...

Regulation of Virulence by a Two-Component System in Group B Streptococcus†

Jiang, Sheng-Mei, Cieslewicz, Michael J., Kasper, Dennis L., Wessels, Michael R.

Group B Streptococcus (GBS) is frequently carried in the gastrointestinal or genitourinary tract as a commensal organism, yet it has the potential to cause life-threatening infection in newborn...

Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides

Cieslewicz, Michael J., Chaffin, Donald, Glusman, Gustavo, Kasper, Dennis, Madan, Anup, Rodrigues, Stephani, ...

Group B Streptococcus (GBS) is an important pathogen of neonates, pregnant women, and immunocompromised individuals. GBS isolates associated with human infection produce one of nine antigenically...

Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome”

Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...

The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...

Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †

Jiang, Sheng-Mei, Ishmael, Nadeeza, Hotopp, Julie Dunning, Puliti, Manuela, Tissi, Luciana, Kumar, Nikhil, ...

CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene...