Michael J. Difilippantonio

In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

Guo, Liying, Hu-Li, Jane, Zhu, Jinfang, Watson, Cynthia J., Difilippantonio, Michael J., Pannetier, Christophe, ...

TH2 clones may produce very variable amounts of IL-4. Among six TH2 clones prepared from homozygous or heterozygous mice in which Gfp replaced the first exon of Il4, a range of patterns of CpG...

Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles

Forgues, Marshonna, Difilippantonio, Michael J., Linke, Steven P., Ried, Thomas, Nagashima, Kunio, Feden, Jeffrey, ...

Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer...

A comprehensive continuous-time model for the appearance of CGH signal due to chromosomal missegregations during mitosis

Desper, Richard, Difilippantonio, Michael J., Ried, Thomas, Schäffer, Alejandro A.

Aneuploidy, the gain or loss of large regions of the genome, is a common feature in cancer cells. Irregularities in chromosomal copy number caused by missegregations of chromosomes during mitosis can...

In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production

Guo, Liying, Hu-Li, Jane, Zhu, Jinfang, Watson, Cynthia J., Difilippantonio, Michael J., Pannetier, Christophe, ...

TH2 clones may produce very variable amounts of IL-4. Among six TH2 clones prepared from homozygous or heterozygous mice in which Gfp replaced the first exon of Il4, a range of patterns of CpG...

Involvement of Crm1 in Hepatitis B Virus X Protein-Induced Aberrant Centriole Replication and Abnormal Mitotic Spindles

Forgues, Marshonna, Difilippantonio, Michael J., Linke, Steven P., Ried, Thomas, Nagashima, Kunio, Feden, Jeffrey, ...

Hepatitis B virus (HBV) includes an X gene (HBx gene) that plays a critical role in liver carcinogenesis. Because centrosome abnormalities are associated with genomic instability in most human cancer...

Artificially Introduced Aneuploid Chromosomes Assume a Conserved Position in Colon Cancer Cells

Sengupta, Kundan, Upender, Madhvi B., Barenboim-Stapleton, Linda, Nguyen, Quang Tri, Wincovitch, Stephen M., Garfield, Susan H., ...

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

Difilippantonio, Simone, Celeste, Arkady, Kruhlak, Michael J., Lee, Youngsoo, Difilippantonio, Michael J., Feigenbaum, Lionel, ...

The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity,...

Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification

Difilippantonio, Michael J., Petersen, Simone, Chen, Hua Tang, Johnson, Roger, Jasin, Maria, Kanaar, Roland, ...

Nonreciprocal translocations and gene amplifications are commonly found in human tumors. Although little is known about the mechanisms leading to such aberrations, tissue culture models predict that...

β-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo▿ †

Xu, Mai, Yu, Qing, Subrahmanyam, Ramesh, Difilippantonio, Michael J., Ried, Thomas, Sen, Jyoti Misra

The expression of β-catenin, a potent oncogene, is causally linked to tumorigenesis. Therefore, it was surprising that the transgenic expression of oncogenic β-catenin in thymocytes resulted in...