Michael J. Gambello

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse (2009)

Way, Sharon W., McKenna, James, Mietzsch, Ulrike, Reith, R. Michelle, Wu, Henry Cheng-ju, Gambello, Michael J.

Tuberous sclerosis complex (TSC) is an autosomal dominant, tumor predisposition disorder characterized by significant neurodevelopmental brain lesions, such as tubers and subependymal nodules. The...

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of 20 genes deleted in a heterozygous fashion in Miller–Dieker syndrome (MDS), a contiguous gene...

Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome (2004)

Toyo-oka, Kazuhito, Hirotsune, Shinji, Gambello, Michael J., Zhou, Zi-Qiang, Olson, Lorin, Rosenfeld, Michael G., ...

The Mnt gene encodes a Mad-family bHLH transcription factor located on human 17p13.3. Mnt is one of twenty genes deleted in a heterozygous fashion in Miller-Dieker syndrome (MDS), a contiguous gene...

LIS1 and dynein motor function in neuronal migration and development (2001)

Wynshaw-Boris, Anthony, Gambello, Michael J.

Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant Mice

Paylor, Richard, Hirotsune, Shinji, Gambello, Michael J., Yuva-Paylor, Lisa, Crawley, Jacqueline N., Wynshaw-Boris, Anthony

Heterozygous mutation or deletion of Pafah1b1 (LIS1) in humans is associated with syndromes with type 1 lissencephaly, a severe brain developmental disorder resulting from abnormal neuronal...

Impaired Learning and Motor Behavior in Heterozygous Pafah1b1 (Lis1) Mutant Mice

Paylor, Richard, Hirotsune, Shinji, Gambello, Michael J., Yuva-Paylor, Lisa, Crawley, Jacqueline N., Wynshaw-Boris, Anthony

Heterozygous mutation or deletion of Pafah1b1 (LIS1) in humans is associated with syndromes with type 1 lissencephaly, a severe brain developmental disorder resulting from abnormal neuronal...

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

Tanaka, Teruyuki, Serneo, Finley F., Higgins, Christine, Gambello, Michael J., Wynshaw-Boris, Anthony, Gleeson, Joseph G.

Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro neuronal migration...

Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner

Rachdi, Latif, Balcazar, Norman, Osorio-Duque, Fernando, Elghazi, Lynda, Weiss, Aaron, Gould, Aaron, ...

Regulation of pancreatic β cell mass and function is a major determinant for the development of diabetes. Growth factors and nutrients are important regulators of β cell mass and function. The...

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

Way, Sharon W., McKenna, James, Mietzsch, Ulrike, Reith, R. Michelle, Wu, Henry Cheng-ju, Gambello, Michael J.

Tuberous sclerosis complex (TSC) is an autosomal dominant, tumor predisposition disorder characterized by significant neurodevelopmental brain lesions, such as tubers and subependymal nodules. The...