An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis (2008)
Silvia S. Kang, Seth M. Bloom, Lyse A. Norian, Michael J. Geske, Richard A. Flavell, Thaddeus S. Stappenbeck, ...
BackgroundThe constellation of human inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, which both display a wide spectrum in the severity of pathology. One theory is...
Michael J. Geske, Valerie A. Ramey, Matthew D. Shapiro
The value of installed computers falls rapidly and therefore computers have a very high user cost. The paper provides a complete account of the non-financial user cost of personal computers --...
Brown, Sarah L., Riehl, Terrence E., Walker, Monica R., Geske, Michael J., Doherty, Jason M., Stenson, William F., ...
We identified cellular and molecular mechanisms within the stem cell niche that control the activity of colonic epithelial progenitors (ColEPs) during injury. Here, we show that while WT mice...
An Antibiotic-Responsive Mouse Model of Fulminant Ulcerative Colitis
Kang, Silvia S, Bloom, Seth M, Norian, Lyse A, Geske, Michael J, Flavell, Richard A, Stappenbeck, Thaddeus S, ...
Paul Allen and colleagues describe the development of a mouse model of fulminant ulcerative colitis with multiple genetic hits in immune regulation which can be moderated by anti-cytokine therapy and...
Efficient colonic mucosal wound repair requires Trem2 signaling
Seno, Hiroshi, Miyoshi, Hiroyuki, Brown, Sarah L., Geske, Michael J., Colonna, Marco, Stappenbeck, Thaddeus S.
The colonic epithelial lining undergoes constant replacement, driven by epithelial stem cells in crypts of Lieberkühn. Stem cells lost because of damage or disease can be replaced by adjacent crypts...