Breining, Scott R., Bencherif, Merouane, Grady, Sharon R., Whiteaker, Paul, Marks, Michael J., Wageman, Charles R., ...
Direct comparison of pyridine versus pyrimidine substituents on a small but diverse set of ligands indicates that the pyrimidine substitution has the potential to enhance affinity and/or functional...
Drenan, Ryan M., Grady, Sharon R., Whiteaker, Paul, McClure-Begley, Tristan, McKinney, Sheri, Miwa, Julie M., ...
α6-containing (α6*) nicotinic ACh receptors (nAChRs) are selectively expressed in dopamine (DA) neurons and participate in cholinergic transmission. We generated and studied mice with...
Whyte, Douglas, Cahir, Elizabeth, Lester, Henry A, Grady, Sharon R, Marks, Michael J, ...
We generated a mouse line harboring an autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) mutation: the alpha 4 nicotinic receptor S248F knock-in strain. In this mouse, modest nicotine doses...
Subtype Enriched, Retinocollicular Afferents, Cecilia Gotti, Milena Moretti, Alessio Zanardi, Annalisa Gaimarri, ...
The activation of neuronal nicotinic acetylcholine receptors (nAChRs) has been implicated in the activity-dependent development and plasticity of retina and the refinement of retinal projections....
The sexual double standard as a group process / (2004)
Thesis (M.A. in Psychology)--University of Illinois at Chicago, 2004.
Pharmacological and Null Mutation Approaches Reveal Nicotinic Receptor Diversity (2000)
Paul Whiteaker, Michael J. Marks, Sharon R. Grady, Ying Lu, Marina R. Picciotto, Jean-Pierre Changeux, ...
w 125 x Z.w 3 x We have developed an array of assays for nicotinic acetylcholine receptor binding and function. I a-Bungarotoxin-, y - H nico- w 3 x tine-, and H epibatidine-binding nicotinic...
Subunit Michael Marks, Michael J. Marks, Paul Whiteaker, Jennifer Calcaterra, Jerry A. Stitzel, Amy E. Bullock, ...
Nicotinic agonist-stimulated efflux of 86 Rb 1 from mouse brain synaptosomes was monitored continuously by on-line radioactivity detection. The concentration-effect curve following a 5-s stimulation...
Ying Lu, Sharon Grady, Michael J. Marks, Marina Picciotto, Jean-Pierre Changeux, Allan C. Collins
Several recent electrophysiological studies have demonstrated that nicotinic agonists stimulate the release of #-aminobutyric acid (GABA) from rodent brain tissue. Our studies used a neurochemical...
Measures of viability in isolated cells (1975)
Medzihradsky, Fedor, Marks, Michael J.
Various methods were compared for estimation of cell viability. Cell count, uptake of trypan blue, release of cellular LDH, as well as cell contents of K+ and Na+ were determined in leukocytes,...
Drug inhibitable ecto-ATPase in leukocytes (1975)
Medzihradsky, Fedor, Lin, Hsia-Lien, Marks, Michael J.
In rat leukocytes, the total ATP-hydrolyzing activity was highest when determined in cells with an intact plasma membrane. The ecto-ATPase, exhibiting a Km for ATP of 0.3 mM, was inhibited 30% by...
Transport and interaction of drugs in leukocytes (1974)
Marks, Michael J., Medzihradsky, Fedor
The accumulation of selected CNS drugs by rat leukocytes was previously reported. This paper presents evidence for the transport into leukocytes of additional drugs. Also studied was the inhibition...
Medzihradsky, Fedor, Marks, Michael J., Metcalfe, Joan I.
A simple procedure is presented for the isolation of erythrocytes, leukocytes and platelets from single small samples of both human and rat blood. The separation of cells is based on sedimentation...
Energy-dependent uptake of benzomorphans by leukocytes (1972)
Medzihradsky, Fedor, Marks, Michael J.
Pentazocine rapidly enters the brain after i.p. administration to rats. Using leukocytes as model mammalian cells, the uptake of this drug was studied. Morphologically intact and metabolically active...
Identification of a novel nicotinic binding site in mouse brain using [125I]-epibatidine
Whiteaker, Paul, Jimenez, Melissa, McIntosh, J Michael, Collins, Allan C, Marks, Michael J
[125I]-Epibatidine binds to multiple nicotinic acetylcholine receptor (nAChR) subtypes with high affinity. In this study, [125I]-epibatidine was used to label and characterize a novel nAChR subtype...