Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential (2007)
Wong, Piu, Iwasaki, Masayuki, Somervaille, Tim C.P., So, Chai Wai Eric, Cleary, Michael L.
Oncogenic mutations of the MLL histone methyltransferase confer an unusual ability to transform non-self-renewing myeloid progenitors into leukemia stem cells (LSCs) by mechanisms that remain poorly...
Deguchi, Kenji, Ayton, Paul M., Carapeti, Melina, Kutok, Jeffery L., Snyder, Cynthia S., Williams, Ifor R., ...
The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that...
Deguchi, Kenji, Ayton, Paul M., Carapeti, Melina, Kutok, Jeffery L., Snyder, Cynthia S., Williams, Ifor R., ...
The MOZ-TIF2 fusion is associated with acute myeloid leukemia (AML) with inv(8)(p11q13). MOZ is a MYST family histone acetyltransferase (HAT), whereas TIF2 is a nuclear receptor coactivator that...
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9 (2003)
Ayton, Paul M., Cleary, Michael L.
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal translocations is a common theme in the pathogenesis of acute leukemias;...
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9 (2003)
Ayton, Paul M., Cleary, Michael L.
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal translocations is a common theme in the pathogenesis of acute leukemias;...
Cozzio, Antonio, Passegué, Emmanuelle, Ayton, Paul M., Karsunky, Holger, Cleary, Michael L., Weissman, Irving L.
We have used the hematopoietic system as a model to investigate whether acute myeloid leukemia arises exclusively from self-renewing stem cells or also from short-lived myeloid progenitors. When...
Progenetix.net: an online repository for molecular cytogenetic aberration data (2001)
Baudis, Michael, Cleary, Michael L.
Summary: Through sequencing projects and, more recently, array-based expression analysis experiments, a wealth of genetic data has become accessible via online resources. In contrast, few of the...
Identification by nucleotide sequence analysis of a goat pseudoglobin gene (1980)
Cleary, Michael L., Haynes, Joel R., Schon, Eric A., Lingrel, Jerry B.
We have recently prepared a recombinant library of goat genomic DNA and have isolated clones containing the known goat globin genes. These include the α, γ, βC and βA genes. In addition to these,...
Typescript.
Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1
De Vivo, Immaculata, Cui, Xiangmin, Domen, Jos, Cleary, Michael L.
SET binding factor 1 (Sbf1) was originally discovered by virtue of its interaction with a highly conserved motif (the SET domain) of unknown function in the protooncoprotein homolog of Drosophila...
Kasper, Lawryn H., Brindle, Paul K., Schnabel, Catherine A., Pritchard, Colin E. J., Cleary, Michael L.
Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with human acute myeloid leukemia (AML),...
Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity
Jacobs, Yakop, Schnabel, Catherine A., Cleary, Michael L.
Pbx/exd proteins modulate the DNA binding affinities and specificities of Hox proteins and contribute to the execution of Hox-dependent developmental programs in arthropods and vertebrates. Pbx...
Firestein, Ron, Cui, Xiangmin, Huie, Phil, Cleary, Michael L.
Mammalian SET domain-containing proteins define a distinctive class of chromatin-associated factors that are targets for growth control signals and oncogenic activation. SUV39H1, a mammalian ortholog...
Smith, Kevin S., Rhee, Joon Whan, Naumovski, Louie, Cleary, Michael L.
The hepatic leukemia factor (HLF) gene codes for a basic region-leucine zipper (bZIP) protein that is disrupted by chromosomal translocations in a subset of pediatric acute lymphoblastic leukemias....
Nagy, Peter L., Griesenbeck, Joachim, Kornberg, Roger D., Cleary, Michael L.
Histone methylation has emerged as an important mechanism for regulating the transcriptional accessibility of chromatin. Several methyltransferases have been shown to target histone amino-terminal...
Slany, Robert K., Lavau, Catherine, Cleary, Michael L.
The HRX gene (also called MLL, ALL-1, and Htrx) at chromosome band 11q23 is associated with specific subsets of acute leukemias through translocations that result in its fusion with a variety of...
So, Chi Wai, Cleary, Michael L.
MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused...
Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2
Smith, Kevin S., Rhee, Joon Whan, Cleary, Michael L.
The chimeric transcription factor E2a-Hlf is an oncoprotein associated with a subset of acute lymphoblastic leukemias of early B-lineage derivation. We employed a retroviral...
Firestein, Ron, Nagy, Peter L., Daly, Megan, Huie, Phil, Conti, Marco, Cleary, Michael L.
Pseudophosphatases display extensive sequence similarities to phosphatases but harbor amino acid alterations in their active-site consensus motifs that render them catalytically inactive. A potential...
Nie, Zuqin, Yan, Zhijiang, Chen, Everett H., Sechi, Salvatore, Ling, Chen, Zhou, Sharleen, ...
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their...
Kim, Soo-A, Vacratsis, Panayiotis O., Firestein, Ron, Cleary, Michael L., Dixon, Jack E.
The myotubularin (MTM) family constitutes one of the most highly conserved protein-tyrosine phosphatase subfamilies in eukaryotes. MTM1, the archetypal member of this family, is mutated in X-linked...
Nagy, Peter L., Cleary, Michael L., Brown, Patrick O., Lieb, Jason D.
Epigenetic modifications of chromatin serve an important role in regulating the expression and accessibility of genomic DNA. We report here a genomewide approach for fractionating yeast chromatin...
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
Ayton, Paul M., Cleary, Michael L.
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal translocations is a common theme in the pathogenesis of acute leukemias;...
Cozzio, Antonio, Passegué, Emmanuelle, Ayton, Paul M., Karsunky, Holger, Cleary, Michael L., Weissman, Irving L.
We have used the hematopoietic system as a model to investigate whether acute myeloid leukemia arises exclusively from self-renewing stem cells or also from short-lived myeloid progenitors. When...
The TALE Homeodomain Protein Pbx2 Is Not Essential for Development and Long-Term Survival
Selleri, Licia, DiMartino, Jorge, Van Deursen, Jan, Brendolan, Andrea, Sanyal, Mrinmoy, Boon, Elles, ...
Pbx2 is one of four mammalian genes that encode closely related TALE homeodomain proteins, which serve as DNA binding partners for a subset of Hox transcription factors. The expression and...
Yokoyama, Akihiko, Wang, Zhong, Wysocka, Joanna, Sanyal, Mrinmoy, Aufiero, Deborah J., Kitabayashi, Issay, ...
MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic histone...
Ayton, Paul M., Chen, Everett H., Cleary, Michael L.
The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric oncoproteins. These invariably contain the amino-terminal 1,400 residues of...
Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1
De Vivo, Immaculata, Cui, Xiangmin, Domen, Jos, Cleary, Michael L.
SET binding factor 1 (Sbf1) was originally discovered by virtue of its interaction with a highly conserved motif (the SET domain) of unknown function in the protooncoprotein homolog of Drosophila...
Kasper, Lawryn H., Brindle, Paul K., Schnabel, Catherine A., Pritchard, Colin E. J., Cleary, Michael L.
Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with human acute myeloid leukemia (AML),...
Trimeric Association of Hox and TALE Homeodomain Proteins Mediates Hoxb2 Hindbrain Enhancer Activity
Jacobs, Yakop, Schnabel, Catherine A., Cleary, Michael L.
Pbx/exd proteins modulate the DNA binding affinities and specificities of Hox proteins and contribute to the execution of Hox-dependent developmental programs in arthropods and vertebrates. Pbx...
Firestein, Ron, Cui, Xiangmin, Huie, Phil, Cleary, Michael L.
Mammalian SET domain-containing proteins define a distinctive class of chromatin-associated factors that are targets for growth control signals and oncogenic activation. SUV39H1, a mammalian ortholog...
Smith, Kevin S., Rhee, Joon Whan, Naumovski, Louie, Cleary, Michael L.
The hepatic leukemia factor (HLF) gene codes for a basic region-leucine zipper (bZIP) protein that is disrupted by chromosomal translocations in a subset of pediatric acute lymphoblastic leukemias....
Nagy, Peter L., Griesenbeck, Joachim, Kornberg, Roger D., Cleary, Michael L.
Histone methylation has emerged as an important mechanism for regulating the transcriptional accessibility of chromatin. Several methyltransferases have been shown to target histone amino-terminal...
Slany, Robert K., Lavau, Catherine, Cleary, Michael L.
The HRX gene (also called MLL, ALL-1, and Htrx) at chromosome band 11q23 is associated with specific subsets of acute leukemias through translocations that result in its fusion with a variety of...
So, Chi Wai, Cleary, Michael L.
MLL-AFX is a fusion gene created by t(X;11) chromosomal translocations in a subset of acute leukemias of either myeloid or lymphoid derivation. It codes for a chimeric protein consisting of MLL fused...
Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2
Smith, Kevin S., Rhee, Joon Whan, Cleary, Michael L.
The chimeric transcription factor E2a-Hlf is an oncoprotein associated with a subset of acute lymphoblastic leukemias of early B-lineage derivation. We employed a retroviral...
Firestein, Ron, Nagy, Peter L., Daly, Megan, Huie, Phil, Conti, Marco, Cleary, Michael L.
Pseudophosphatases display extensive sequence similarities to phosphatases but harbor amino acid alterations in their active-site consensus motifs that render them catalytically inactive. A potential...
Nie, Zuqin, Yan, Zhijiang, Chen, Everett H., Sechi, Salvatore, Ling, Chen, Zhou, Sharleen, ...
The SWI/SNF family of chromatin-remodeling complexes has been discovered in many species and has been shown to regulate gene expression by assisting transcriptional machinery to gain access to their...
Kim, Soo-A, Vacratsis, Panayiotis O., Firestein, Ron, Cleary, Michael L., Dixon, Jack E.
The myotubularin (MTM) family constitutes one of the most highly conserved protein-tyrosine phosphatase subfamilies in eukaryotes. MTM1, the archetypal member of this family, is mutated in X-linked...
Nagy, Peter L., Cleary, Michael L., Brown, Patrick O., Lieb, Jason D.
Epigenetic modifications of chromatin serve an important role in regulating the expression and accessibility of genomic DNA. We report here a genomewide approach for fractionating yeast chromatin...
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
Ayton, Paul M., Cleary, Michael L.
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal translocations is a common theme in the pathogenesis of acute leukemias;...
Cozzio, Antonio, Passegué, Emmanuelle, Ayton, Paul M., Karsunky, Holger, Cleary, Michael L., Weissman, Irving L.
We have used the hematopoietic system as a model to investigate whether acute myeloid leukemia arises exclusively from self-renewing stem cells or also from short-lived myeloid progenitors. When...
The TALE Homeodomain Protein Pbx2 Is Not Essential for Development and Long-Term Survival
Selleri, Licia, DiMartino, Jorge, Van Deursen, Jan, Brendolan, Andrea, Sanyal, Mrinmoy, Boon, Elles, ...
Pbx2 is one of four mammalian genes that encode closely related TALE homeodomain proteins, which serve as DNA binding partners for a subset of Hox transcription factors. The expression and...
Yokoyama, Akihiko, Wang, Zhong, Wysocka, Joanna, Sanyal, Mrinmoy, Aufiero, Deborah J., Kitabayashi, Issay, ...
MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic histone...
Ayton, Paul M., Chen, Everett H., Cleary, Michael L.
The MLL gene is a frequent target for leukemia-associated chromosomal translocations that generate dominant-acting chimeric oncoproteins. These invariably contain the amino-terminal 1,400 residues of...
Pbx3 Deficiency Results in Central Hypoventilation
Rhee, Joon Whan, Arata, Akiko, Selleri, Licia, Jacobs, Yakop, Arata, Satoru, Onimaru, Hiroshi, ...
Pbx proteins comprise a family of TALE (three amino acid loop extension) class homeodomain transcription factors that are implicated in developmental gene expression through their abilities to form...
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
Wong, Piu, Iwasaki, Masayuki, Somervaille, Tim C.P., So, Chai Wai Eric, Cleary, Michael L.
Oncogenic mutations of the MLL histone methyltransferase confer an unusual ability to transform non-self-renewing myeloid progenitors into leukemia stem cells (LSCs) by mechanisms that remain poorly...
B-cell development fails in the absence of the Pbx1 proto-oncogene
Sanyal, Mrinmoy, Tung, James W., Karsunky, Holger, Zeng, Hong, Selleri, Licia, Weissman, Irving L., ...
Pbx1, a homeodomain transcription factor that was originally identified as the product of a proto-oncogene in acute pre-B–cell leukemia, is a global regulator of embryonic development. However,...