Complement and arthritis: another step in understanding (2008)
Frank, Michael M, Hester, C Garren
Abstract In a recent research article in Arthritis Research and Therapy ('Analysis of C204 and the C4 binding protein in the MRL/lpr mouse'), Wenderfer and colleagues report that deficiency in C4...
Miami transportation center /--[Michael M. Frank] (1986)
Title supplied by cataloger.
Shevach, Ethan M., Herberman, Ronald, Frank, Michael M., Green, Ira
The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC′). Monocytes and...
Atkinson, John P., Frank, Michael M.
Purified human IgM isoagglutinins were utilized to sensitize 51Cr-labeled erythrocytes so as to produce a known number of complement-fixing sites. These cells were then reinfused into the erythrocyte...
Schreiber, Aland D., Frank, Michael M.
A model which permits evaluation in molecular terms of the role of antibody and of complement in the immune destruction of erythrocytes was established in the guinea pig. IgM and IgG immunoglobulins...
Schreiber, Alan D., Frank, Michael M.
A model for the immune clearance and destruction of homologous erythrocytes has been further explored. In this model, every IgM anti-erythrocyte antibody molecule in an antibody preparation was shown...
Kane, Michael A., May, Joseph E., Frank, Michael M.
The contributions of the classical and alternate pathways of complement activation to the biological effects of endotoxin have been examined in the guinea pig, with particular reference to...
Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes
Atkinson, John P., Schreiber, Alan D., Frank, Michael M.
Corticosteroids and splenectomy constitute two important therapeutic modalities in the treatment of autoimmune hemolytic anemia. Each of these may affect both the rate of synthesis of autoantibody...
Atkinson, John P., Frank, Michael M.
The clearance of 51Cr-labeled guinea pig erythrocytes, sensitized with a known amount of IgM or IgG antibody, was examined in normal and BCG-infected guinea pigs. In normal animals, IgM-coated cells...
Gadek, James E., Fulmer, Jack D., Gelfand, Jeffrey A., Frank, Michael M., Petty, Thomas L., Crystal, Ronald G.
Individuals with serum α1-antitrypsin levels below 80 mg/dl are clearly at risk for the development of accelerated panacinar emphysema. One possible approach to the therapy of this disorder would be...
Jaffe, Charles J., Vierling, John M., Jones, E. Anthony, Lawley, Thomas J., Frank, Michael M.
An approach to the assessment of reticuloendothelial function that quantitates clearance specifically mediated by membrane receptors for C3b and immunoglobulin (Ig)G has been applied in man....
Response of Variant Hereditary Angioedema Phenotypes to Danazol Therapy: GENETIC IMPLICATIONS
Gadek, James E., Hosea, Stephen W., Gelfand, Jeffrey A., Frank, Michael M.
Hereditary angioedema (HAE), an auto-somal dominant disorder characterized by attacks of episodic edema is associated with decreased functional levels of the C1 esterase inhibitor. Approximately 85%...
A New Complement-Mediated Cytolytic Mechanism—the C1-Bypass Activation Pathway
May, Joseph E., Frank, Michael M.
A new cytolytic pathway is described whereby cells sensitized with cytotoxic antibody can be specifically lysed in the complete absence of intact, classical complement pathway function. Evaluation of...
Bypassing complement: evolutionary lessons and future implications
Atkinson, John P., Frank, Michael M.
Lectins like mannan-binding protein are part of the innate immune system. They circulate in association with serine proteases. Upon binding oligosaccharides, they activate the complement cascade...
Shevach, Ethan M., Herberman, Ronald, Frank, Michael M., Green, Ira
The bone marrow-derived (B) lymphocyte can be identified by the presence of easily detectable surface immunoglobulin and a receptor for antigen-antibody-complement complexes (EAC′). Monocytes and...
Atkinson, John P., Frank, Michael M.
Purified human IgM isoagglutinins were utilized to sensitize 51Cr-labeled erythrocytes so as to produce a known number of complement-fixing sites. These cells were then reinfused into the erythrocyte...
Schreiber, Aland D., Frank, Michael M.
A model which permits evaluation in molecular terms of the role of antibody and of complement in the immune destruction of erythrocytes was established in the guinea pig. IgM and IgG immunoglobulins...
Schreiber, Alan D., Frank, Michael M.
A model for the immune clearance and destruction of homologous erythrocytes has been further explored. In this model, every IgM anti-erythrocyte antibody molecule in an antibody preparation was shown...
Kane, Michael A., May, Joseph E., Frank, Michael M.
The contributions of the classical and alternate pathways of complement activation to the biological effects of endotoxin have been examined in the guinea pig, with particular reference to...
Effects of Corticosteroids and Splenectomy on the Immune Clearance and Destruction of Erythrocytes
Atkinson, John P., Schreiber, Alan D., Frank, Michael M.
Corticosteroids and splenectomy constitute two important therapeutic modalities in the treatment of autoimmune hemolytic anemia. Each of these may affect both the rate of synthesis of autoantibody...
Atkinson, John P., Frank, Michael M.
The clearance of 51Cr-labeled guinea pig erythrocytes, sensitized with a known amount of IgM or IgG antibody, was examined in normal and BCG-infected guinea pigs. In normal animals, IgM-coated cells...
Gadek, James E., Fulmer, Jack D., Gelfand, Jeffrey A., Frank, Michael M., Petty, Thomas L., Crystal, Ronald G.
Individuals with serum α1-antitrypsin levels below 80 mg/dl are clearly at risk for the development of accelerated panacinar emphysema. One possible approach to the therapy of this disorder would be...
Jaffe, Charles J., Vierling, John M., Jones, E. Anthony, Lawley, Thomas J., Frank, Michael M.
An approach to the assessment of reticuloendothelial function that quantitates clearance specifically mediated by membrane receptors for C3b and immunoglobulin (Ig)G has been applied in man....
Response of Variant Hereditary Angioedema Phenotypes to Danazol Therapy: GENETIC IMPLICATIONS
Gadek, James E., Hosea, Stephen W., Gelfand, Jeffrey A., Frank, Michael M.
Hereditary angioedema (HAE), an auto-somal dominant disorder characterized by attacks of episodic edema is associated with decreased functional levels of the C1 esterase inhibitor. Approximately 85%...
A New Complement-Mediated Cytolytic Mechanism—the C1-Bypass Activation Pathway
May, Joseph E., Frank, Michael M.
A new cytolytic pathway is described whereby cells sensitized with cytotoxic antibody can be specifically lysed in the complete absence of intact, classical complement pathway function. Evaluation of...
Bypassing complement: evolutionary lessons and future implications
Atkinson, John P., Frank, Michael M.
Lectins like mannan-binding protein are part of the innate immune system. They circulate in association with serine proteases. Upon binding oligosaccharides, they activate the complement cascade...
THE SUBUNITS IN RABBIT ANTI-FORSSMAN IGM ANTIBODY
Frank, Michael M., Humphrey, John H.
Rabbit IgM anti-Forssman antibody was highly purified and the subunits obtained on reduction and alkylation were labeled radioactively and isolated by two different and unrelated methods. In both...
IN VITRO STUDIES OF COMPLEMENT FUNCTION IN SERA OF C4-DEFICIENT GUINEA PIGS
Frank, Michael M., May, Joseph, Gaither, Thelma, Ellman, Leonard
In vitro studies were performed utilizing sera from a strain of guinea pigs with a total absence of hemolytically active C4. Previous studies in these animals have demonstrated normal...
IN VIVO STUDIES IN C4-DEFICIENT GUINEA PIGS
Ellman, Leonard, Green, Ira, Judge, Francis, Frank, Michael M.
Guinea pigs with a genetically determined total deficiency of the fourth component of complement have been studied for various in vivo immunological functions. Passive cutaneous anaphylaxsis, contact...
Gelfand, Michael C., Elfenbein, Gerald J., Frank, Michael M., Paul, William E.
Many bursa-equivalent (B) lymphocytes of adult mice bear surface Ig and receptors for C3. The frequency of Ig-bearing cells increases rapidly immediately after birth, but these cells lack complement...
Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway
Jiang, Haixiang, Wagner, Eric, Zhang, Huamei, Frank, Michael M.
We studied complement 1 inhibitor (C1-INH) as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, of paroxysmal nocturnal...
Complement and arthritis: another step in understanding
Frank, Michael M, Hester, C Garren
In a recent research article in Arthritis Research and Therapy ('Analysis of C204 and the C4 binding protein in the MRL/lpr mouse'), Wenderfer and colleagues report that deficiency in C4 binding...