Mitochondrial depolarization and the role of uncoupling proteins in ischemia tolerance (2006)
Modest depolarization of the mitochondrial inner membrane potential is known to attenuate mitochondrial reactive oxygen species generation. Transient pharmacologic uncoupling of mitochondrial...
Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning (2004)
Smith, Robert M., Suleman, Naushaad, Lacerda, Lydia, Opie, Lionel H., Akira, Shizuo, Chien, Kenneth R., ...
Objective: To evaluate the functional requirement of signal transducer and activator of transcription-3 (STAT-3) in cardiac myocyte tolerance to ischemia (I) and in classical preconditioning....
Minners, Jan, McLeod, Christopher J., Sack, Michael N.
Ischemic preconditioning is a powerful biologic phenomenon that activates innate cell survival programs to protect the heart from ischemic injury. The preponderance of research into classical...
Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program (2002)
Smith, Robert M, Lecour, Sandrine, Sack, Michael N
Ischemic preconditioning is thought to evoke cell survival programs in the heart in large part via the activation of GI-protein coupled receptor signal transduction pathways. However, the...
Smith, Robert M, Suleman, Naushaad, McCarthy, Joy, Sack, Michael N
Objective: Tumor necrosis factor alpha (TNF) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNF-preconditioning is mediated by established preconditioning...
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Minners, Jan, Van Den Bos, Ewout J, Yellon, Derek M, Schwalb, Herzl, Opie, Lionel H, Sack, Michael N
Background: Recent studies have postulated that mitochondrial ATP-sensitive potassium (mitoKATP) channel activation may modulate mitochondrial function with the resultant induction of a...
A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
Sack, Michael N., Disch, Dennis L., Rockman, Howard A., Kelly, Daniel P.
During cardiac hypertrophy, the chief myocardial energy source switches from fatty acid β-oxidation (FAO) to glycolysis—a reversion to fetal metabolism. The expression of genes encoding myocardial...
A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
Sack, Michael N., Disch, Dennis L., Rockman, Howard A., Kelly, Daniel P.
During cardiac hypertrophy, the chief myocardial energy source switches from fatty acid β-oxidation (FAO) to glycolysis—a reversion to fetal metabolism. The expression of genes encoding myocardial...
Shiva, Sruti, Sack, Michael N., Greer, James J., Duranski, Mark, Ringwood, Lorna A., Burwell, Lindsay, ...
Nitrite (NO2−) is an intrinsic signaling molecule that is reduced to NO during ischemia and limits apoptosis and cytotoxicity at reperfusion in the mammalian heart, liver, and brain. Although the...
Pagel-Langenickel, Ines, Bao, Jianjun, Joseph, Joshua J., Schwartz, Daniel R., Mantell, Benjamin S., Xu, Xiuli, ...
The pathophysiology underlying mitochondrial dysfunction in insulin-resistant skeletal muscle is incompletely characterized. To further delineate this we investigated the interaction between insulin...
Lu, Zhongping, Sack, Michael N.
Hypoxia induces oxidative damage in skeletal muscle. Uncoupling protein 3 (UCP3) is the skeletal muscle enriched uncoupling protein and has previously been shown to confer resistance against...