A New Idea for Welfare Reform (2009)
This article analyzes several proposals to build work incentives into the U.S. welfare system. It concludes that the most cost effective way to do that is to offer a work subsidy to all low-income...
Thanh N. Huynh, S. Sam Weigt, John A. Belperio, Mary Territo, Michael P. Keane
The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who require admission to the intensive care unit (ICU) has been regarded as extremely poor. We sought to re-evaluate recent...
Thanh N. Huynh, S. Sam Weigt, John A. Belperio, Mary Territo, Michael P. Keane
The prognosis of patients with hematopoietic stem cell transplants (HSCTs) who require admission to the intensive care unit (ICU) has been regarded as extremely poor. We sought to re-evaluate recent...
Sauer, Robert, Keane, Michael P.
This paper develops a new simulation estimation algorithm that is particularly useful for estimating dynamic panel data models with unobserved endogenous state variables. The new approach can deal...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection (2005)
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying, Strieter, Robert M
Abstract Background Respiratory viral infections are characterized by the infiltration of leukocytes, including activated neutrophils into the lung that can lead to sustained lung injury and...
Bognanno, Mario F, Keane, Michael P, Yang, Donghoon
Using the Benchmark and Annual Surveys of U.S. Direct Investment Abroad collected by the Bureau of Economic Analysis, the authors examine the operations of U.S. multinational corporations (MNCs) in...
Assessing the Impact of Welfare Reform on Single Mothers (2004)
Fang, Hanming., Keane, Michael P.
Brookings Papers on Economic Activity - 2004, 1
Keane, Michael P, Strieter, Robert M
Abstract The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of...
Macrophage infiltration in human non-small-cell lung cancer: the role of CC chemokines (2000)
DiGiovine, Bruno, Burdick, Marie D., Arenberg, Douglas A., Kunkel, Steven L., Strieter, Robert M., Strom, Scott R. B., ...
Bronchogenic carcinoma is the leading cause of malignancy-related mortality in the United States, with an overall 5-year survival rate of less than 15%. This aggressive behavior reflects, among...
CXC chemokines mechanism of action in regulating tumor angiogenesis (1998)
Moore, Bethany B., Arenberg, Douglas A., Addison, Christina L., Keane, Michael P., Polverini, Peter J., Strieter, Robert M.
The CXC chemokines have recently been identified as a family of molecules which can regulate angiogenesis. Members of this family which contain the amino acid motif Glu–Leu–Arg in their amino...
Single and double ionisation of free molecules and condensed matter /--by Michael P. Keane. (1991)
Thesis (doctoral)--Uppsala University, 1991.
Changes in the Structure of Earnings During the Polish Transition
Eswar Prasad, Michael P. Keane
Wages , Poland , Labor ,
Statistical inference in the multinomial multiperiod probit model
John F. Geweke, Michael P. Keane, David E. Runkle
Statistical inference in multinomial multiperiod probit models has been hindered in the past by the high dimensional numerical integrations necessary to form the likelihood functions, posterior...
Michael P. Keane, Kenneth I. Wolpin
Over the past decade, a substantial literature on the estimation of discrete choice dynamic programming (DC-DP) models of behavior has developed. However, this literature now faces major...
Michael P. Keane, Kenneth I. Wolpin
Using data from the NLSY79, we structurally estimate a dynamic model of the life cycle decisions of young women. The women make joint and sequential decisions about school attendance, work, marriage,...
Michael P. Keane, Kenneth I. Wolpin
Opportunities for external validation of behavioral models in the social sciences that are based on randomized social experiments or on large regime shifts, that can be treated as experiments for the...
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
Keane, Michael P, Strieter, Robert M
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal...
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Huang, Min, Sharma, Sherven, Zhu, Li X., Keane, Michael P., Luo, Jie, Zhang, Ling, ...
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis
Strieter, Robert M., Keane, Michael P.
New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3–expressing cells, specifically...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
An empirical analysis of income dynamics among men in the PSID: 1968-1989
John F. Geweke, Michael P. Keane
This study uses data from the Panel Survey of Income Dynamics (PSID) to address a number of questions about life cycle earnings mobility. It develops a dynamic reduced form model of earnings and...
Sources of Advantageous Selection: Evidence from the Medigap Insurance Market
Hanming Fang, Michael P. Keane, Dan Silverman
We provide strong evidence of advantageous selection in the Medigap insurance market, and analyze its sources. Using Medicare Current Beneficiary Survey (MCBS) data, we find that, conditional on...
Michael P. Keane, Robert M. Sauer
Two key issues in the literature on female labor supply are: (1) if persistence in employment status is due to unobserved heterogeneity or state dependence, and (2) if fertility is exogenous to labor...
Are economic forecasts rational?
Michael P. Keane, David E. Runkle
This paper discusses at an undergraduate level how forecast rationality can be tested. It explains that forecasters should correctly use any relevant information they knew in making their...
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
Keane, Michael P, Strieter, Robert M
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to the destruction of normal...
IL-7 inhibits fibroblast TGF-β production and signaling in pulmonary fibrosis
Huang, Min, Sharma, Sherven, Zhu, Li X., Keane, Michael P., Luo, Jie, Zhang, Ling, ...
Based on studies by our group and others, we hypothesized that IL-7 may possess antifibrotic activities in an IFN-γ–dependent and independent manner. Here, we have evaluated the antifibrotic...
Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury
Belperio, John A., Keane, Michael P., Burdick, Marie D., Londhe, Vedang, Xue, Ying Ying, Li, Kewang, ...
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal...
Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Lynch, Joseph P., Xue, Ying Ying, Berlin, Aaron, ...
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte...
Innate immunity dictates cytokine polarization relevant to the development of pulmonary fibrosis
Strieter, Robert M., Keane, Michael P.
New data support the importance of the innate immune response in the resolution or progression of pulmonary fibrosis. The presence of CXC chemokine receptor 3–expressing cells, specifically...
Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis
Phillips, Roderick J., Burdick, Marie D., Hong, Kurt, Lutz, Marin A., Murray, Lynne A., Xue, Ying Ying, ...
Previous reports have identified a circulating pool of CD45+ collagen I+ CXCR4+ (CD45+Col I+CXCR4+) cells, termed fibrocytes, that traffic to areas of fibrosis. No studies have demonstrated that...
Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
Belperio, John A., Keane, Michael P., Burdick, Marie D., Gomperts, Brigitte, Xue, Ying Ying, Hong, Kurt, ...
Angiogenesis and vascular remodeling support fibroproliferative processes; however, no study has addressed the importance of angiogenesis during fibro-obliteration of the allograft airway during...
CXCR2 is critical for dsRNA-induced lung injury: relevance to viral lung infection
Londhe, Vedang A, Belperio, John A, Keane, Michael P, Burdick, Marie D, Xue, Ying Ying, Strieter, Robert M
The role of CXC chemokines in pulmonary fibrosis
Strieter, Robert M., Gomperts, Brigitte N., Keane, Michael P.
The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in...
Mario F. Bognanno, Michael P. Keane, Donghoon Yang
Using the Benchmark and Annual Surveys of U.S. Direct Investment Abroad collected by the Bureau of Economic Analysis, the authors examine the operations of U.S. multinational corporations (MNCs) in...
Assessing the Impact of Welfare Reform on Single Mothers
Hanming Fang, Michael P. Keane
macroeconomics, Welfare Reform, Single Mothers
Intertemporal Labor Supply and Human Capital Accumulation
We solve and estimate a dynamic model that allows agents to optimally choose their labor hours and consumption and that allows for both human capital accumulation and savings. Estimation results and...
Assessing the Impact of Welfare Reform on Single Mothers
Hanming Fang, Michael P. Keane
macroeconomics, Welfare Reform, Single Mothers
Money, Political Ambition, and the Career Decisions of Politicians
Michael P. Keane, Antonio Merlo
In this paper we assess the impact of a variety of policies that may influence the career decisions of members of the U.S. Congress, using the empirical framework of Diermeier, Keane and Merlo...
Assessing the Impact of Welfare Reform on Single Mothers
Hanming Fang, Michael P. Keane
macroeconomics, Welfare Reform, Single Mothers
Keane, Michael P, Sauer, Robert M
This paper develops a new simulation estimation algorithm that is particularly useful for estimating dynamic panel data models with unobserved endogenous state variables. The new approach can deal...
MICHAEL P. KEANE, SUSAN E. FEINBERG
Intra-firm trade in intermediates between U.S. multinational parents (MNCs) and their Canadian manufacturing affiliates increased dramatically in the 1984-1995 period (i.e., it roughly doubled)....
Trade Liberalization and Delocalization: New Evidence from Firm-Level Panel Data
Susan E. Feinberg, Michael P. Keane, Mario F. Bognanno
The authors examine how U.S. multinational corporations (MNCs) and their Canadian affiliates responded to the substantial bilateral tariff reductions that occurred over the 1983-92 period. Using...
Accounting for the Growth of MNC-Based Trade Using a Structural Model of U.S. MNCs
Susan E. Feinberg, Michael P. Keane
In recent decades, U.S. foreign trade grew much faster than GDP, but there is no consensus why. Notably lacking is an understanding of the role of multinational corporations (MNCs), which mediate...
Michael P. Keane, Kenneth I. Wolpin
A particularly challenging use of decision-theoretic models in economics is to forecast the impact of large changes in the environment. The problem we explore in this article is how to gain...
Mario F. Bognanno, Michael P. Keane, Donghoon Yang
Using the Benchmark and Annual Surveys of U.S. Direct Investment Abroad collected by the Bureau of Economic Analysis, the authors examine the operations of U.S. multinational corporations (MNCs) in...
Robert M. Sauer, Michael P. Keane
This paper develops a new simulation estimation algorithm that is particularly useful for estimating dynamic panel data models with unobserved endogenous state variables. The new approach can deal...
A Computationally Practical Simulation Estimator for Panel Data.
The author develops a practical extension of D. McFadden's method of simulated moments estimator for limited dependent variable models to the panel data case. The method is based on factorization of...
Nominal-Contracting Theories of Unemployment: Evidence from Panel Data.
This paper examines economywide and sector-specific responses of real wages to nominal shocks using micro panel data from the National Longitudinal Survey of Young Men. The observed response patterns...
Testing the Rationality of Price Forecasts: New Evidence from Panel Data.
Keane, Michael P, Runkle, David E
This paper tests the rationality of individual price forecasts in a panel of professional forecasters. Here, unlike in most previous studies, rationality is not rejected. The results here differ...
Inequality, Transfers and Growth: New Evidence from the Economic Transition in Poland
Keane, Michael P., Prasad, Eswar S.
This paper analyzes the evolution of inequality in Poland during the economic transition that began in 1989-90. Using micro data from the Household Budget Surveys, we find that, after a brief spike...
Changes in the Structure of Earnings During the Polish Transition
Keane, Michael P., Prasad, Eswar S.
We document changes in the structure of earnings during the economic transition in Poland. We find that inequality in labor earnings increased substantially from 1988 to 1996. A common view is that...
Modeling Heterogeneity and State Dependence in Consumer Choice Behavior.
In frequently-purchased-consumer-goods markets, consumer brand choices exhibit substantial persistence across purchase occasions. In this article, the author estimates a choice model that admits of...
A Note on Identification in the Multinomial Probit Model.
Although formal conditions for identification in the multinational probit model are now clearly established, little is known about how various estimable multinational probit specifications perform in...
Mixture of normals probit models
John F. Geweke, Michael P. Keane
This paper generalizes the normal probit model of dichotomous choice by introducing mixtures of normals distributions for the disturbance term. By mixing on both the mean and variance parameters and...
Business cycles ; Economics
Nominal contracting theories of unemployment: evidence from panel data
This paper examines the response of real wages and employment probabilities to nominal shocks using micro-panel data from the National Longitudinal Survey of Young Men. Both economy-wide and...
Sectoral shift theories of unemployment: evidence from panel data
This paper examines the response of sectoral real wages and location probabilities to oil price shocks using U.S. micro-panel data (the National Longitudinal Survey of Young Men). The goal is to...
The relation between skill levels and the cyclical variability of employment, hours and wages
Michael P. Keane, Eswar S. Prasad
This paper uses micro data to examine differences in the cyclical variability of employment, hours, and wages for skilled and unskilled workers. Contrary to conventional wisdom, we find that, at the...
The employment and wage effects of oil price shocks: a sectoral analysis
Michael P. Keane, Eswar S. Prasad
In this paper we use micro panel data to examine the effects of oil price shocks on employment and real wages, at the aggregate and industry levels. We also measure differences in the employment and...
Individual heterogeneity and interindustry wage differentials
Estimates of interindustry wage differentials are obtained using a fixed-effects estimator on a long panel, the National Longitudinal Survey of Young Men (NLS). After controlling for observable...
The career decisions of young men
Michael P. Keane, Kenneth I. Wolpin
Career development - Sex differences
A structural model of multiple welfare program participation and labor supply
Michael P. Keane, Robert Moffitt
One of the long-standing issues in the literature on transfer programs for the U.S. low-income population concerns the high cumulative marginal tax rate on earnings induced by participation in the...
Bayesian inference for dynamic choice models without the need for dynamic programming
John F. Geweke, Michael P. Keane
Programming (Mathematics)
Inequality, Transfers, And Growth: New Evidence From The Economic Transition In Poland
Michael P. Keane, Eswar S. Prasad
This paper analyzes the evolution of inequality in Poland during the economic transition that began in 1989-1990. Using microdata from the Household Budget Surveys, we find that, after a brief spike...
U.S.-Canada Trade Liberalization And Mnc Production Location
Susan E. Feinberg, Michael P. Keane
Using confidential firm-level panel data from the Bureau of Economic Analysis, we examine how the bilateral trade flows of U.S. multinational corporations (MNCs) and their Canadian affiliates...
The Employment and Wage Effects of Oil Price Changes: A Sectoral Analysis.
Keane, Michael P, Prasad, Eswar S
In this paper, we use micro panel data to examine the effects of oil price changes on employment and real wages, at the aggregate and industry levels. We also measure differences in the employment...
Keane, Michael P, Wolpin, Kenneth I
Over the past decade, a substantial literature on methods for the estimation of discrete choice dynamic programming (DDP) models of behavior has developed. However, the implementation of these...
Alternative Computational Approaches to Inference in the Multinomial Probit Model.
Geweke, John, Keane, Michael P, Runkle, David
This research compares several approaches to inference in the multinominal profit model, based on two Monte Carlo experiments for a seven choice model. The methods compared are the simulated maximum...
The Employment and Wage Effects of Oil Price Changes: A Sectoral Analysis
Eswar Prasad, Michael P. Keane
Oil prices , Wages , Employment , Skilled labor ,
The Relation Between Skill Levels and the Cyclical Variability of Employment, Hours, and Wages
Eswar Prasad, Michael P. Keane
Labor markets , Skilled labor , Employment , Wages ,
Consumption and Income Inequality in Poland During the Economic Transition
Eswar Prasad, Michael P. Keane
Consumption , Poland , Income ,
Inequality, Transfers and Growth - New Evidence from the Economic Transition in Poland
Eswar Prasad, Michael P. Keane
Economic growth , Poland , Transition economies , Income , Economic reform ,
Keratinocyte Growth Factor Improves Repair in the Injured Tracheal Epithelium
Gomperts, Brigitte N., Belperio, John A., Fishbein, Michael C., Keane, Michael P., Burdick, Marie D., Strieter, Robert M.
Keratinocyte growth factor (KGF) is a critical growth factor in lung development and is a protective agent after lung injury, although the exact mechanisms of this protective effect have not yet been...
Empirical Applications of Discrete Choice Dynamic Programming Models
Michael P. Keane, Kenneth I. Wolpin
The development over the past 25 years of methods for the estimation of discrete choice dynamic programming (DCDP) models opened up new frontiers for empirical research in a host of areas, including...
Eliminating Race Differences in School Attainment and Labor Market Success.
Keane, Michael P, Wolpin, Kenneth I
In this article, we provide quantitative evidence on the effects of monetary incentive schemes designed to reduce racial differences in school attainment and earnings. Our analysis is based on the...
The Career Decisions of Young Men.
Keane, Michael P, Wolpin, Kenneth I
This paper provides structural estimates of a dynamic model of schooling, work, and occupational choice decisions based on eleven years of observations on a sample of young men from the 1979 youth...
Eliminating Race Differences in School Attainment and Labor Market Success
Michael P. Keane, Kenneth Wolpin
Between 1940 and 1980, the average school attainment of black men increased by about 1.5 years every decade, about .5 years more than for white men. Similarly, over the same period real income more...
Sources of Advantageous Selection: Evidence from the Medigap Insurance Market
Hanming Fang, Michael P. Keane, Dan Silverman
We provide evidence of advantageous selection in the Medigap insurance market and analyze its sources. Conditional on controls for Medigap prices, those with Medigap spend, on average, $4,000 less on...
Keane, Michael P., Sauer, Robert M.
This paper develops a simulation estimation algorithm that is particularly useful for estimating dynamic panel data models with unobserved endogenous state variables. The new approach can easily deal...
Michael P. Keane, Robert M. Sauer
Two key issues in the literature on female labor supply are (i) whether persistence in employment status is due to unobserved heterogeneity or state dependence, and (ii) whether fertility is...
Keane, Michael P., Roemer, John E.
The inter-generational correlation of education in the U.S. is tremendous. For instance, in PSID data from 1990, young males with college-educated parents had a 70% chance of attending college. But...
SIMULATED MAXIMUM LIKELIHOOD ESTIMATION BASED ON FIRST-ORDER CONDITIONS
I describe a strategy for structural estimation that uses simulated maximum likelihood (SML) to estimate the structural parameters appearing in a model's first-order conditions (FOCs). Generalized...