p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication (2009)
Gürlevik, Engin, Woller, Norman, Schache, Peter, Malek, Nisar P., Wirth, Thomas C., Zender, Lars, ...
RNA-interference (RNAi) is a potent tool for specific gene silencing. In this study, we developed an adenovirus for conditional replication in p53-dysfunctional tumor cells that uses p53-selective...
Bachmann, Oliver, Franke, Kristin, Yu, Haoyang, Riederer, Brigitte, Li, Hong C, Soleimani, Manoocher, ...
Abstract Background The renal (kNBC1) and intestinal (pNBC1) electrogenic Na + /HCO 3 - cotransporter variants differ in their primary structure, transport direction, and response to secretagogues....
Hafer, Anne, Krämer, Sigrid, Duncker, Swantje, Krüger, Martin, Manns, Michael P, Bischoff, Stephan C
Abstract Background The prebiotic potential of lactulose is well established and preclinical studies demonstrated a protective effect of lactulose in murine models of colitis. The aim of the present...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response (2007)
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Abstract Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees...
Rifai, Kinan, Kirchner, Gabriele I., Bahr, Matthias J., Cantz, Tobias, Rosenau, Jens, Nashan, Björn, ...
Little is known about hearing impairment in patients after organ transplantation. We conducted a single-center study to evaluate hearing impairment in patients after orthotopic liver transplantation...
Wiegand, Johannes, Buggisch, Peter, Boecher, Wulf, Zeuzem, Stefan, Gelbmann, Cornelia M., Berg, Thomas, ...
Early treatment of acute hepatitis C with interferon alpha-2b for 24 weeks prevents chronic infection in almost all patients. Because pegylated interferons have replaced conventional interferon in...
Zschemisch, Nils-Holger, Cohrs, Anne, Borlak, Jürgen, Manns, Michael P, ...
BACKGROUND & AIMS: Caspase-8 is the apical caspase essential for triggering Fas-induced apoptosis. In this study, we investigated caspase-8 expression in hepatocellular carcinomas (HCCs) using...
Assmus, Ulrike, Wüstefeld, Torsten, Meyer Zu Vilsendorf, Andreas, Schmidt-Supprian, Mark, ...
The inhibitor of NF-kappaB (I-kappaB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-kappaB essential modulator (NEMO), and is involved in the activation of NF-kappaB by various...
Wüstefeld, Torsten, Assmus, Ulrike, Rose-John, Stefan, Müller, Michael, ...
Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6 activates intracellular pathways via the gp130 receptor. In order to identify IL-6-gp130 pathways involved...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression (2004)
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Antal Csepregi, Petra Obermayer-Straub, Susanne Kneip, Anne Kayser, Stephanie Loges, Eleonore Schmidt, ...
Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC). The analysis of...
Tobias Cantz, David M. Zuckerman, Martin R. Burda, Maura Dandri, Maura D, Bettina Göricke, ...
Alpha fetoprotein gene expression had already decreased 2 weeks after transplantation in EGFP-positive regeneration nodules compared to pretransplantation values and was not detectable after 4 and 6...
Antal Csepregi, Petra Obermayer-Straub, Susanne Kneip, Anne Kayser, Stephanie Loges, Eleonore Schmidt, ...
Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC). The analysis of...
High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C (1995)
Clifford, Bernard D., Donahue, Daniel, Smith, Lynda, Cable, Edward Earl, Luttig, Brigit, Manns, Michael P., ...
The advent of specific antiviral therapy for chronic hepatitis C has increased the importance of establishing the correct etiology of chronic hepatitis in patients, especially because interferon alfa...
Mainz, Univ., Fachbereich 05-10 - Medizin, Diss., 1976.
Delaney, William E., Edwards, Ros, Colledge, Danni, Shaw, Tim, Torresi, Joseph, Miller, Thomas G., ...
Long-term nucleoside analog therapy for hepatitis B virus (HBV)-related disease frequently results in the selection of mutant HBV strains that are resistant to therapy. Molecular studies of such...
Krüger, Martin, Beger, Carmela, Welch, Peter J., Barber, Jack R., Manns, Michael P., Wong-Staal, Flossie
Ribozymes are small catalytic RNA molecules that can be engineered to enzymatically cleave RNA transcripts in a sequence-specific fashion and thereby inhibit expression and function of the...
Bock, C.-Thomas, Malek, Nisar P., Tillmann, Hans L., Manns, Michael P., Trautwein, Christian
Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Long-term interaction of the immune system with the virus results in the selection of escape...
Telomere length is reset during early mammalian embryogenesis
Schaetzlein, Sonja, Lucas-Hahn, Andrea, Lemme, Erika, Kues, Wilfried A., Dorsch, Martina, Manns, Michael P., ...
The enzyme telomerase is active in germ cells and early embryonic development and is crucial for the maintenance of telomere length. Whereas the different length of telomeres in germ cells and...
Tacke, Frank, Gehrke, Christina, Luedde, Tom, Heim, Albert, Manns, Michael P., Trautwein, Christian
During chronic hepatitis B virus (HBV) infection, mutations in the precore (PC) or basal core promoter (BCP) region affecting HBV e antigen (HBeAg) expression occur commonly and represent the...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Klein, Christian, Wüstefeld, Torsten, Assmus, Ulrike, Roskams, Tania, Rose-John, Stefan, Müller, Michael, ...
Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6 activates intracellular pathways via the gp130 receptor. In order to identify IL-6–gp130 pathways involved...
Luedde, Tom, Assmus, Ulrike, Wüstefeld, Torsten, Meyer Zu Vilsendorf, Andreas, Roskams, Tania, Schmidt-Supprian, Mark, ...
The inhibitor of NF-κB (I-κB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-κB essential modulator (NEMO), and is involved in the activation of NF-κB by various stimuli. IKK2 or...
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Lechel, André, Satyanarayana, Ande, Ju, Zhenyu, Plentz, Ruben R, Schaetzlein, Sonja, Rudolph, Cornelia, ...
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect...
Delaney, William E., Edwards, Ros, Colledge, Danni, Shaw, Tim, Torresi, Joseph, Miller, Thomas G., ...
Long-term nucleoside analog therapy for hepatitis B virus (HBV)-related disease frequently results in the selection of mutant HBV strains that are resistant to therapy. Molecular studies of such...
Krüger, Martin, Beger, Carmela, Welch, Peter J., Barber, Jack R., Manns, Michael P., Wong-Staal, Flossie
Ribozymes are small catalytic RNA molecules that can be engineered to enzymatically cleave RNA transcripts in a sequence-specific fashion and thereby inhibit expression and function of the...
Bock, C.-Thomas, Malek, Nisar P., Tillmann, Hans L., Manns, Michael P., Trautwein, Christian
Chronic hepatitis B virus (HBV) infection can lead to liver cirrhosis and hepatocellular carcinoma. Long-term interaction of the immune system with the virus results in the selection of escape...
Telomere length is reset during early mammalian embryogenesis
Schaetzlein, Sonja, Lucas-Hahn, Andrea, Lemme, Erika, Kues, Wilfried A., Dorsch, Martina, Manns, Michael P., ...
The enzyme telomerase is active in germ cells and early embryonic development and is crucial for the maintenance of telomere length. Whereas the different length of telomeres in germ cells and...
Tacke, Frank, Gehrke, Christina, Luedde, Tom, Heim, Albert, Manns, Michael P., Trautwein, Christian
During chronic hepatitis B virus (HBV) infection, mutations in the precore (PC) or basal core promoter (BCP) region affecting HBV e antigen (HBeAg) expression occur commonly and represent the...
Skp2-dependent degradation of p27kip1 is essential for cell cycle progression
Kossatz, Uta, Dietrich, Nils, Zender, Lars, Buer, Jan, Manns, Michael P., Malek, Nisar P.
The activity of the SCFskp2 E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a...
Klein, Christian, Wüstefeld, Torsten, Assmus, Ulrike, Roskams, Tania, Rose-John, Stefan, Müller, Michael, ...
Increasing evidence demonstrates that IL-6 has a protective role during liver injury. IL-6 activates intracellular pathways via the gp130 receptor. In order to identify IL-6–gp130 pathways involved...
Luedde, Tom, Assmus, Ulrike, Wüstefeld, Torsten, Meyer Zu Vilsendorf, Andreas, Roskams, Tania, Schmidt-Supprian, Mark, ...
The inhibitor of NF-κB (I-κB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-κB essential modulator (NEMO), and is involved in the activation of NF-κB by various stimuli. IKK2 or...
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo
Lechel, André, Satyanarayana, Ande, Ju, Zhenyu, Plentz, Ruben R, Schaetzlein, Sonja, Rudolph, Cornelia, ...
Telomere dysfunction induces two types of cellular response: cellular senescence and apoptosis. We analysed the extent to which the cellular level of telomere dysfunction and p53 gene status affect...
Timmerbeul, Inke, Garrett-Engele, Carrie M., Kossatz, Uta, Chen, Xueyan, Firpo, Eduardo, Grünwald, Viktor, ...
Decreased expression of the CDK inhibitor p27kip1 in human tumors directly correlates with increased resistance to chemotherapies, increased rates of metastasis, and an overall increased rate of...
Cantz, Tobias, Zuckerman, David M., Burda, Martin R., Dandri, Maura, Göricke, Bettina, Thalhammer, Stefan, ...
Therapies for liver diseases with stem and progenitor cells will require a detailed knowledge of the molecular mechanisms driving the in vivo differentiation process toward adult hepatic tissue. We...
Clearance of low levels of HCV viremia in the absence of a strong adaptive immune response
Meyer, Manuela F, Lehmann, Marc, Cornberg, Markus, Wiegand, Johannes, Manns, Michael P, Klade, Christoph, ...
Spontaneous clearance of hepatitis C virus (HCV) has frequently been associated with the presence of HCV-specific cellular immunity. However, there had been also reports in chimpanzees demonstrating...
Hafer, Anne, Krämer, Sigrid, Duncker, Swantje, Krüger, Martin, Manns, Michael P, Bischoff, Stephan C
C-terminal phosphorylation controls the stability and function of p27kip1
Kossatz, Uta, Vervoorts, Jörg, Nickeleit, Irina, Sundberg, Holly A, Arthur, J Simon C, Manns, Michael P, ...
Entry of cells into the cell division cycle requires the coordinated activation of cyclin-dependent kinases (cdks) and the deactivation of cyclin kinase inhibitors. Degradation of p27kip1 is known to...
Kirchner, Gabriele I, Winkler, Michael, Mueller, Lueke, Vidal, Christian, Jacobsen, Wolfgang, Franzke, Anke, ...
Csepregi, Antal, Obermayer-Straub, Petra, Kneip, Susanne, Kayser, Anne, Loges, Stephanie, Schmidt, Eleonore, ...
Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC). The analysis of...
Human Endothelial Cells Regulate Survival and Proliferation of Human Mast Cells
Mierke, Claudia T., Ballmaier, Matthias, Werner, Uwe, Manns, Michael P., Welte, Karl, Bischoff, Stephan C.
Mast cells (MCs) are immunoregulatory and inflammatory tissue cells preferentially located around blood vessels. Since endothelial cells have been suggested to regulate MC functions, we analyzed...
Csepregi, Antal, Obermayer-Straub, Petra, Kneip, Susanne, Kayser, Anne, Loges, Stephanie, Schmidt, Eleonore, ...
Background and aims: Antimitochondrial antibodies (AMA) which recognize pyruvate acetyltransferase (PDC-E2) represent a highly diagnostic feature of primary biliary cirrhosis (PBC). The analysis of...
Obermann, Sonja, Petrykowska, Susanne, Manns, Michael P, Korangy, Firouzeh, Greten, Tim F
Adoptive T-cell therapy represents a promising therapeutic approach for the treatment of cancer. Successful adoptive immunotherapy depends on the ex vivo priming and expansion of antigen-specific T...
Bachmann, Oliver, Franke, Kristin, Yu, Haoyang, Riederer, Brigitte, Li, Hong C, Soleimani, Manoocher, ...
Jiang, Hong, Schiffer, Eric, Song, Zhangfa, Wang, Jianwei, Zürbig, Petra, Thedieck, Kathrin, ...
Telomere dysfunction limits the proliferative capacity of human cells by activation of DNA damage responses, inducing senescence or apoptosis. In humans, telomere shortening occurs in the vast...
p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication
Gürlevik, Engin, Woller, Norman, Schache, Peter, Malek, Nisar P., Wirth, Thomas C., Zender, Lars, ...
RNA-interference (RNAi) is a potent tool for specific gene silencing. In this study, we developed an adenovirus for conditional replication in p53-dysfunctional tumor cells that uses p53-selective...
Stem cells in liver regeneration and therapy
Cantz, Tobias, Manns, Michael P., Ott, Michael
The liver has adapted to the inflow of ingested toxins by the evolutionary development of unique regenerative properties and responds to injury or tissue loss by the rapid division of mature cells....
Ehmer, Ursula, Lankisch, Tim O., Erichsen, Thomas J., Kalthoff, Sandra, Freiberg, Nicole, Wehmeier, Michael, ...
Gilbert’s syndrome causes mild, unconjugated hyperbilirubinemia and is present in approximately 10% of the Caucasian population. The basis of the disorder is a 70% reduction in bilirubin...
Beckmann, Max G., Bahr, Matthias J., Hadem, Johannes, Bredt, Martin, Wedemeyer, Heiner, Schneider, Andrea S., ...
Background. Transjugular liver biopsy (TJLB) is frequently used to obtain liver specimens in high-risk patients. However, TJLB sample size possibly limits their clinical relevance. Methods. 102...