Michael P. Myers, Jay Yang, Per Stampe
We have constructed a fusion protein between mSlo (a recombinant, high conductance, calcium-activated potassium channel or maxi-K), and GFP (green fluorescent protein). This construct represents a...
HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis (2004)
Ajit Janardhan, Tomek Swigut, Brian Hill, Michael P. Myers, Jacek Skowronski
The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase...
Myers, Michael P., Yang, Jay, Stampe, Per
We have constructed a fusion protein between (mSlo) (a recombinant, high conductance, calcium-activated potassium channel or Maxi-K), and GFP (green flourescent protein). This construct represents a...
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
Myers, Michael P., Stolarov, Javor P., Eng, Charis, Li, Jing, Wang, Steven I., Wigler, Michael H., ...
Protein tyrosine phosphatases (PTPs) have long been thought to play a role in tumor suppression due to their ability to antagonize the growth promoting protein tyrosine kinases. Recently, a candidate...
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
Myers, Michael P., Pass, Ian, Batty, Ian H., Van Der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., ...
Since their discovery, protein tyrosine phosphatases have been speculated to play a role in tumor suppression because of their ability to antagonize the growth-promoting protein tyrosine kinases....
PTEN controls tumor-induced angiogenesis
Wen, Shenghua, Stolarov, Javor, Myers, Michael P., Su, Jing Dong, Wigler, Michael H., Tonks, Nicholas K., ...
Mutations of the tumor suppressor PTEN, a phosphatase with specificity for 3-phosphorylated inositol phospholipids, accompany progression of brain tumors from benign to the most malignant forms....
Hu, Ping, Wu, Si, Sun, Yuling, Yuan, Chih-Chi, Kobayashi, Ryuji, Myers, Michael P., ...
Unlike Saccharomyces cerevisiae RNA polymerase III, human RNA polymerase III has not been entirely characterized. Orthologues of the yeast RNA polymerase III subunits C128 and C37 remain...
Wysocka, Joanna, Myers, Michael P., Laherty, Carol D., Eisenman, Robert N., Herr, Winship
The abundant and chromatin-associated protein HCF-1 is a critical player in mammalian cell proliferation as well as herpes simplex virus (HSV) transcription. We show here that separate regions of...
HIV-1 Nef Binds the DOCK2–ELMO1 Complex to Activate Rac and Inhibit Lymphocyte Chemotaxis
Janardhan, Ajit, Swigut, Tomek, Hill, Brian, Myers, Michael P, Skowronski, Jacek
The infectious cycle of primate lentiviruses is intimately linked to interactions between cells of the immune system. Nef, a potent virulence factor, alters cellular environments to increase...
Regulation of Adeno-Associated Virus DNA Replication by the Cellular TAF-I/Set Complex†
Pegoraro, Gianluca, Marcello, Alessandro, Myers, Michael P., Giacca, Mauro
The Rep proteins of the adeno-associated virus (AAV) are required for viral replication in the presence of adenovirus helper functions and as yet poorly characterized cellular factors. In an attempt...
Control of Pre-mRNA Splicing by the General Splicing Factors PUF60 and U2AF65
Hastings, Michelle L., Allemand, Eric, Duelli, Dominik M., Myers, Michael P., Krainer, Adrian R.
Pre-mRNA splicing is a crucial step in gene expression, and accurate recognition of splice sites is an essential part of this process. Splice sites with weak matches to the consensus sequences are...
A primate virus generates transformed human cells by fusion
Duelli, Dominik M., Hearn, Stephen, Myers, Michael P., Lazebnik, Yuri
Amodel that explains both the origin and sporadic nature of cancer argues that cancer cells are a chance result of events that cause genomic and epigenetic variability. The prevailing view is that...
Hoa, Neil, Myers, Michael P., Douglass, Thomas G., Zhang, Jian Gang, Delgado, Christina, Driggers, Lara, ...
Paraptosis is the programmed cell death pathway that leads to cellular necrosis. Previously, rodent and human monocytes/macrophages killed glioma cells bearing the membrane macrophage colony...