Sheng-mei Jiang, Nadeeza Ishmael, Manuela Puliti, Luciana Tissi, Nikhil Kumar, ...
in the group B Streptococcus CsrRS regulon and effects on pathogenicity
Measurement of Human Antibodies to Type III Group B Streptococcus
Kasper, Dennis L., Wessels, Michael R., Guttormsen, Hilde-Kari, Paoletti, Lawrence C., Edwards, Morven S., Baker, Carol J.
Ashbaugh, Cameron D., Wessels, Michael R.
The cysteine protease of group A streptococci has been suggested to contribute to the pathogenesis of invasive infection through degradation of host tissue, activation of the host inflammatory...
Ashbaugh, Cameron D., Albertí, Sebastián, Wessels, Michael R.
Enzymes directing the biosynthesis of the group A streptococcal hyaluronic acid capsule are encoded in the hasABC gene cluster. Inactivation of hasC, encoding UDP-glucose pyrophosphorylase in the...
Wessels, Michael R., Paoletti, Lawrence C., Guttormsen, Hilde-Kari, Michon, Francis, D’Ambra, Anello J., Kasper, Dennis L.
In this study, we tested the hypothesis that the immunogenicity and protective efficacy of polysaccharide-protein conjugate vaccines are influenced by three variables: (i) molecular size of the...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....
Sierig, Gabriele, Cywes, Colette, Wessels, Michael R., Ashbaugh, Cameron D.
Although the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (GAS) has been established, the effect of these molecules in natural infection is not well...
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
Malley, Richard, Henneke, Philipp, Morse, Sarah C., Cieslewicz, Michael J., Lipsitch, Marc, Thompson, Claudette M., ...
Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contribute...
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+
Gryllos, Ioannis, Levin, James C., Wessels, Michael R.
Group A streptococci control expression of key virulence determinants via the two-component sensor/regulator system CsrR/CsrS. The membrane-bound sensor CsrS is thought to respond to previously...
Levy, Ofer, Jean-Jacques, Rochelle M., Cywes, Colette, Sisson, Richard B., Zarember, Kol A., Godowski, Paul J., ...
Group B Streptococcus (GBS) is a major cause of newborn sepsis and meningitis and induces systemic release of tumor necrosis factor alpha (TNF-α), believed to play a role in morbidity and mortality....
CD44 as a receptor for colonization of the pharynx by group A Streptococcus
Cywes, Colette, Stamenkovic, Ivan, Wessels, Michael R.
The pharynx is the primary reservoir for strains of group A Streptococcus (GAS) associated both with pharyngitis (streptococcal sore throat) and with invasive or “flesh-eating” soft tissue...
Regulation of Virulence by a Two-Component System in Group B Streptococcus†
Jiang, Sheng-Mei, Cieslewicz, Michael J., Kasper, Dennis L., Wessels, Michael R.
Group B Streptococcus (GBS) is frequently carried in the gastrointestinal or genitourinary tract as a commensal organism, yet it has the potential to cause life-threatening infection in newborn...
Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides
Cieslewicz, Michael J., Chaffin, Donald, Glusman, Gustavo, Kasper, Dennis, Madan, Anup, Rodrigues, Stephani, ...
Group B Streptococcus (GBS) is an important pathogen of neonates, pregnant women, and immunocompromised individuals. GBS isolates associated with human infection produce one of nine antigenically...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...
The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...
Role of NADase in Virulence in Experimental Invasive Group A Streptococcal Infection
Bricker, Angela L., Carey, Vincent J., Wessels, Michael R.
Group A streptococci (GAS) produce several exoproteins that are thought to contribute to the pathogenesis of human infection. Two such proteins, streptolysin O (SLO) and NAD+-glycohydrolase (NADase),...
Srivastava, Amit, Henneke, Philipp, Visintin, Alberto, Morse, Sarah C., Martin, Victoria, Watkins, Claire, ...
Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to...
Measurement of Human Antibodies to Type III Group B Streptococcus
Kasper, Dennis L., Wessels, Michael R., Guttormsen, Hilde-Kari, Paoletti, Lawrence C., Edwards, Morven S., Baker, Carol J.
Ashbaugh, Cameron D., Wessels, Michael R.
The cysteine protease of group A streptococci has been suggested to contribute to the pathogenesis of invasive infection through degradation of host tissue, activation of the host inflammatory...
Ashbaugh, Cameron D., Albertí, Sebastián, Wessels, Michael R.
Enzymes directing the biosynthesis of the group A streptococcal hyaluronic acid capsule are encoded in the hasABC gene cluster. Inactivation of hasC, encoding UDP-glucose pyrophosphorylase in the...
Wessels, Michael R., Paoletti, Lawrence C., Guttormsen, Hilde-Kari, Michon, Francis, D’Ambra, Anello J., Kasper, Dennis L.
In this study, we tested the hypothesis that the immunogenicity and protective efficacy of polysaccharide-protein conjugate vaccines are influenced by three variables: (i) molecular size of the...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Eisen, Jonathan A., Peterson, Scott, Wessels, Michael R., ...
The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes....
Sierig, Gabriele, Cywes, Colette, Wessels, Michael R., Ashbaugh, Cameron D.
Although the toxicity of streptolysin O (SLO) and streptolysin S (SLS) in purified group A streptococci (GAS) has been established, the effect of these molecules in natural infection is not well...
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
Malley, Richard, Henneke, Philipp, Morse, Sarah C., Cieslewicz, Michael J., Lipsitch, Marc, Thompson, Claudette M., ...
Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to contribute...
The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+
Gryllos, Ioannis, Levin, James C., Wessels, Michael R.
Group A streptococci control expression of key virulence determinants via the two-component sensor/regulator system CsrR/CsrS. The membrane-bound sensor CsrS is thought to respond to previously...
Levy, Ofer, Jean-Jacques, Rochelle M., Cywes, Colette, Sisson, Richard B., Zarember, Kol A., Godowski, Paul J., ...
Group B Streptococcus (GBS) is a major cause of newborn sepsis and meningitis and induces systemic release of tumor necrosis factor alpha (TNF-α), believed to play a role in morbidity and mortality....
CD44 as a receptor for colonization of the pharynx by group A Streptococcus
Cywes, Colette, Stamenkovic, Ivan, Wessels, Michael R.
The pharynx is the primary reservoir for strains of group A Streptococcus (GAS) associated both with pharyngitis (streptococcal sore throat) and with invasive or “flesh-eating” soft tissue...
Regulation of Virulence by a Two-Component System in Group B Streptococcus†
Jiang, Sheng-Mei, Cieslewicz, Michael J., Kasper, Dennis L., Wessels, Michael R.
Group B Streptococcus (GBS) is frequently carried in the gastrointestinal or genitourinary tract as a commensal organism, yet it has the potential to cause life-threatening infection in newborn...
Cytolysin-dependent evasion of lysosomal killing
Håkansson, Anders, Bentley, Colette Cywes, Shakhnovic, Elizabeth A., Wessels, Michael R.
Local host defenses limit proliferation and systemic spread of pathogenic bacteria from sites of mucosal colonization. For pathogens such as streptococci that fail to grow intracellularly,...
Structural and Genetic Diversity of Group B Streptococcus Capsular Polysaccharides
Cieslewicz, Michael J., Chaffin, Donald, Glusman, Gustavo, Kasper, Dennis, Madan, Anup, Rodrigues, Stephani, ...
Group B Streptococcus (GBS) is an important pathogen of neonates, pregnant women, and immunocompromised individuals. GBS isolates associated with human infection produce one of nine antigenically...
Tettelin, Hervé, Masignani, Vega, Cieslewicz, Michael J., Donati, Claudio, Medini, Duccio, Ward, Naomi L., ...
The development of efficient and inexpensive genome sequencing methods has revolutionized the study of human bacterial pathogens and improved vaccine design. Unfortunately, the sequence of a single...
Role of NADase in Virulence in Experimental Invasive Group A Streptococcal Infection
Bricker, Angela L., Carey, Vincent J., Wessels, Michael R.
Group A streptococci (GAS) produce several exoproteins that are thought to contribute to the pathogenesis of human infection. Two such proteins, streptolysin O (SLO) and NAD+-glycohydrolase (NADase),...
Srivastava, Amit, Henneke, Philipp, Visintin, Alberto, Morse, Sarah C., Martin, Victoria, Watkins, Claire, ...
Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to...
Levy, Ofer, Suter, Eugénie E., Miller, Richard L., Wessels, Michael R.
Newborns are prone to microbial infection and have poor memory responses to multiple antigens. We have previously shown that human neonatal blood monocytes exhibit impaired TNF-α responses to most...
Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †
Jiang, Sheng-Mei, Ishmael, Nadeeza, Hotopp, Julie Dunning, Puliti, Manuela, Tissi, Luciana, Kumar, Nikhil, ...
CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene...
Gryllos, Ioannis, Grifantini, Renata, Colaprico, Annalisa, Cary, Max E., Hakansson, Anders, Carey, David W., ...
The peroxide response transcriptional regulator, PerR, is thought to contribute to virulence of group A Streptococcus (GAS); however, the specific mechanism through which it enhances adaptation for...
Induction of group A Streptococcus virulence by a human antimicrobial peptide
Gryllos, Ioannis, Tran-Winkler, Hien J., Cheng, Ming-Fang, Chung, Hachung, Bolcome, Robert, Lu, Wuyuan, ...
Group A streptococci (Streptococcus pyogenes or GAS) freshly isolated from individuals with streptococcal sore throat or invasive (“flesh-eating”) infection often grow as mucoid colonies on...