Evidence for a Complex Mosaic Genome Pattern in a Full-length Hepatitis C Virus Sequence (2008)
Viazov, Sergei, Roggendorf, Michael
The genome of the hepatitis C virus (HCV) exhibits a high genetic variability. This remarkable heterogeneity is mainly attributed to the gradual accumulation of mutational changes, whereas the...
Supported by the German Hepatitis Network (BMBF) and the (2007)
Joerg Timm, Michael Roggendorf, Deutsche Forschungsgemeinschaft
With approximately 3 % of the world’s population (170 million people) infected with the hepatitis C virus (HCV), the WHO has declared HCV a global health problem. Upon acute infection about 50%-80...
Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Pestka, Jan, Zeisel, Mirjam, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, François-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Reinhard, Thomas, Ross, Rudolf S, Böhringer, Daniel, Cartsburg, Olaf, Roggendorf, Michael, ...
OBJECTIVE: To evaluate the efficacy of cidofovir 1% eyedrops with and without cyclosporin A 1% eyedrops as a treatment of acute adenoviral keratoconjunctivitis (AKC). DESIGN: Randomized, controlled...
Pützer, Brigitte M., Stiewe, Thorsten, Rödicker, Florian, Schildgen, Oliver, Rühm, Stefan, Dirsch, Olaf, ...
Background: Cytokine-based gene therapy strategies efficiently stimulate immune responses against many established transplanted tumors, leading to rejection of the tumor. In this study, we...
Lu, Mengji, Hilken, Gero, Kruppenbacher, Johannes, Kemper, Thekla, Schirmbeck, Reinhold, Reimann, Joerg, ...
DNA vaccination can induce humoral and cellular immune response to viral antigens and confer protection to virus infection. In woodchucks, we tested the protective efficacy of immune response to...
Menne, Stephan, Maschke, Jan, Lu, Mengji, Grosse-Wilde, Hans, Roggendorf, Michael
The infection of woodchucks with woodchuck hepatitis virus (WHV) provides an experimental model to study early immune responses during hepadnavirus infection that cannot be tested in patients. The...
Sequence Heterogeneity of TT Virus and Closely Related Viruses
Khudyakov, Yury E., Cong, Mian-er, Nichols, Barbara, Reed, Deoine, Dou, Xiao-Guang, Viazov, Sergei O., ...
TT virus (TTV) is a recently discovered infectious agent originally obtained from transfusion-related hepatitis. However, the causative link between the TTV infection and liver disease remains...
Lu, Mengji, Hilken, Gero, Yang, Dongliang, Kemper, Thekla, Roggendorf, Michael
Woodchuck hepatitis virus (WHV) mutants with core internal deletions (CID) occur naturally in chronically WHV-infected woodchucks, as do hepatitis B virus mutants in humans. We studied the...
Siegel, Felix, Lu, Mengji, Roggendorf, Michael
DNA vaccinations are able to induce strong cellular immune responses in mice and confer protection against infectious agents. However, DNA vaccination of large animals appears to be less effective...
Lu, Mengji, Lohrengel, Beate, Hilken, Gero, Kemper, Thekla, Roggendorf, Michael
Gamma interferon (IFN-γ) is an important mediator with multiple functions in the host defense against viral infection. IFN-γ, in concert with tumor necrosis factor alpha (TNF-α), leads to a...
Menne, Stephan, Roneker, Carol A., Roggendorf, Michael, Gerin, John L., Cote, Paul J., Tennant, Bud C.
In vitro proliferation of peripheral blood mononuclear cells was used to measure virus-specific cell-mediated immunity (vCMI) following neonatal woodchuck hepatitis virus (WHV) infection. Fifteen...
Fiedler, Melanie, Rödicker, Florian, Salucci, Valentina, Lu, Mengji, Aurisicchio, Luigi, Dahmen, Uta, ...
Alpha interferon (IFN-α) and IFN-γ are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects...
Lu, Mengji, Hilken, Gero, Kruppenbacher, Johannes, Kemper, Thekla, Schirmbeck, Reinhold, Reimann, Joerg, ...
DNA vaccination can induce humoral and cellular immune response to viral antigens and confer protection to virus infection. In woodchucks, we tested the protective efficacy of immune response to...
Menne, Stephan, Maschke, Jan, Lu, Mengji, Grosse-Wilde, Hans, Roggendorf, Michael
The infection of woodchucks with woodchuck hepatitis virus (WHV) provides an experimental model to study early immune responses during hepadnavirus infection that cannot be tested in patients. The...
Sequence Heterogeneity of TT Virus and Closely Related Viruses
Khudyakov, Yury E., Cong, Mian-er, Nichols, Barbara, Reed, Deoine, Dou, Xiao-Guang, Viazov, Sergei O., ...
TT virus (TTV) is a recently discovered infectious agent originally obtained from transfusion-related hepatitis. However, the causative link between the TTV infection and liver disease remains...
Lu, Mengji, Hilken, Gero, Yang, Dongliang, Kemper, Thekla, Roggendorf, Michael
Woodchuck hepatitis virus (WHV) mutants with core internal deletions (CID) occur naturally in chronically WHV-infected woodchucks, as do hepatitis B virus mutants in humans. We studied the...
Siegel, Felix, Lu, Mengji, Roggendorf, Michael
DNA vaccinations are able to induce strong cellular immune responses in mice and confer protection against infectious agents. However, DNA vaccination of large animals appears to be less effective...
Lu, Mengji, Lohrengel, Beate, Hilken, Gero, Kemper, Thekla, Roggendorf, Michael
Gamma interferon (IFN-γ) is an important mediator with multiple functions in the host defense against viral infection. IFN-γ, in concert with tumor necrosis factor alpha (TNF-α), leads to a...
Menne, Stephan, Roneker, Carol A., Roggendorf, Michael, Gerin, John L., Cote, Paul J., Tennant, Bud C.
In vitro proliferation of peripheral blood mononuclear cells was used to measure virus-specific cell-mediated immunity (vCMI) following neonatal woodchuck hepatitis virus (WHV) infection. Fifteen...
Fiedler, Melanie, Rödicker, Florian, Salucci, Valentina, Lu, Mengji, Aurisicchio, Luigi, Dahmen, Uta, ...
Alpha interferon (IFN-α) and IFN-γ are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects...
Pestka, Jan M., Zeisel, Mirjam B., Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, Francois-Loïc, ...
In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C is poorly defined. The analysis of...
Frank, Ina, Budde, Claudia, Fiedler, Melanie, Dahmen, Uta, Viazov, Sergei, Lu, Mengji, ...
Woodchucks infected with woodchuck hepatitis virus (WHV) are an excellent model for studying acute, self-limited and chronic hepadnaviral infections. Defects in the immunological response leading to...
Lu, Mengji, Yao, Xin, Xu, Yang, Lorenz, Heike, Dahmen, Uta, Chi, Haidong, ...
The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including...
Neumann-Haefelin, Christoph, Frick, David N., Wang, Jing Jing, Pybus, Oliver G., Salloum, Shadi, Narula, Gagandeep S., ...
Failure of the adaptive immune response to control infection with the hepatitis C virus (HCV) can result from mutational escape in targeted T-cell epitopes. Recent studies suggest that T-cell immune...
Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs ▿
Salloum, Shadi, Oniangue-Ndza, Cesar, Neumann-Haefelin, Christoph, Hudson, Laura, Giugliano, Silvia, Aus Dem Siepen, Marc, ...
The inherent sequence diversity of the hepatitis C virus (HCV) represents a major hurdle for the adaptive immune system to control viral replication. Mutational escape within targeted CD8 epitopes...