Quinn, Jennifer J., Ma, Quang D., Tinsley, Matthew R., Koch, Christof, Fanselow, Michael S.
Retrograde amnesia following disruptions of hippocampal function is often temporally graded, with recent memories being more impaired. Evidence supports the existence of one or more neocortical...
Trace fear conditioning is enhanced in mice lacking the {delta} subunit of the GABAA receptor (2005)
Wiltgen, Brian J., Sanders, Matthew J., Ferguson, Carolyn, Homanics, Gregg E., Fanselow, Michael S.
The δ subunit of the GABAA receptor (GABAAR) is highly expressed in the dentate gyrus of the hippocampus. Genetic deletion of this subunit reduces synaptic and extrasynaptic inhibition and decreases...
Trace fear conditioning is enhanced in mice lacking the {delta} subunit of the GABAA receptor (2005)
Wiltgen, Brian J., Sanders, Matthew J., Ferguson, Carolyn, Homanics, Gregg E., Fanselow, Michael S.
The δ subunit of the GABAA receptor (GABAAR) is highly expressed in the dentate gyrus of the hippocampus. Genetic deletion of this subunit reduces synaptic and extrasynaptic inhibition and decreases...
Trace but not delay fear conditioning requires attention and the anterior cingulate cortex (2003)
Han, C. J., O'Tuathaigh, Colm M., Van Trigt, Laurent, Quinn, Jennifer J., Fanselow, Michael S., Mongeau, Raymond, ...
Higher cognitive functions such as attention have been difficult to model in genetically tractable organisms. In humans, attention-distracting stimuli interfere with trace but not delay conditioning,...
Scopolamine and Pavlovian fear conditioning in rats: dose-effect analysis (1999)
Anagnostaras, Stephan G., Maren, Stephen, Sage, Jennifer R., Goodrich, Stacy, Fanselow, Michael S.
Muscarinic-cholinergic antagonism produces learning and memory deficits in a wide variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia...
Anagnostaras, Stephan G., Maren, Stephen, Fanselow, Michael S.
We have shown previously that electrolytic lesions of the dorsal hippocampus (DH) produce a severe deficit in contextual fear if made 1 d, but not 28 d, after fear conditioning (). As such, the...
Maren, Stephen, Fanselow, Michael S.
The present experiments compared the effects of 2 appetitive motivational states on the acquisition of Pavlovian fear conditioning in rats (Rattus norvegicus). In Experiment 1, rats were deprived of...
Rosen, Jeffrey B., Fanselow, Michael S., Young, Stacey L., Sitcoske, Martin, Maren, Stephen
This study investigated the increase in expression in the amygdala of 2 immediate-early genes, c-fos and NGFI-A, following contextual fear conditioning. The immediate-shock freezing deficit paradigm...
De Oca, Beatrice M., DeCola, Joseph P., Maren, Stephen, Fanselow, Michael S.
In fear conditioning, a rat is placed in a distinct environment and delivered footshock. The response to the footshock itself is called an activity burst and includes running, jumping, and...
Anagnostaras, Stephan G., Maren, Stephen, DeCola, Joseph P., Lane, Nathan I., Gale, Greg D., Schlinger, Barney A., ...
We recently reported that Pavlovian fear conditioning and hippocampal perforant-path long-term potentiation (LTP) are sexually dimorphic in rats. Males show greater contextual fear conditioning,...
The startled seahorse: is the hippocampus necessary for contextual fear conditioning? (1998)
Maren, Stephen, Anagnostaras, Stephan G., Fanselow, Michael S.
Peer Reviewed
Neurotoxic lesions of the dorsal hippocampus and Pavlovian fear conditioning in rats (1997)
Maren, Stephen, Aharonov, Gal, Fanselow, Michael S.
Electrolytic lesions of the dorsal hippocampus (DH) produce deficits in both the acquisition and expression of conditional fear to contextual stimuli in rats. To assess whether damage to DH neurons...
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Maren, Stephen, Fanselow, Michael S.
Recent data indicate that dorsal hippocampal (DH) lesions disrupt Pavlovian fear conditioning to contextual cues in rats. In the present study, we examined the effects of electrolytic lesions of the...
Maren, Stephen, Aharonov, Gal, Stote, Deborah L., Fanselow, Michael S.
Three experiments examined the effects of intra-amygdaloid infusions of an N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), on contextual fear conditioning in...
Maren, Stephen, Aharonov, Gal, Fanselow, Michael S.
The role of the basolateral amygdala (LA) in the acquisition and expression of Pavlovian fear conditioning was examined in 80 rats. Excitotoxic lesions were made in the BLA using N-methyl-D-aspartate...
The amygdala and fear conditioning: has the nut been cracked? (1996)
Maren, Stephen, Fanselow, Michael S.
Peer Reviewed
Maren, Stephen, Fanselow, Michael S.
Several studies suggest that axonal projections from the hippocampal formation (HF) to the basolateral amygdala (BLA) play a role in Pavlovian fear conditioning to contextual conditional stimuli. We...
Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats (1995)
Anagnostaras, Stephan G., Maren, Stephen, Fanselow, Michael S.
Muscarinic cholinergic antagonism produces learning and memory deficits in a variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia for...
Maren, Stephen, De Oca, Beatrice, Fanselow, Michael S.
Three experiments investigated sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats. Experiment 1 revealed a robust sex difference in the magnitude of...
Water deprivation enhances fear conditioning to contextual, but not discrete, stimuli in rats (1994)
Maren, Stephen, DeCola, Joseph P., Fanselow, Michael S.
Water-deprived and nondeprived rats were fear conditioned with a discrete tone conditional stimulus (CS) and an aversive footshock unconditional stimulus (US). Twenty-four and 48 hr following...
Maren, Stephen, DeCola, Joseph P., Swain, Rodney A., Fanselow, Michael S., Thompson, Richard F.
The influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and...
Naloxone and Pavlovian fear conditioning / (1980)
Thesis--University of Washington.
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Mihalek, Robert M., Banerjee, Pradeep K., Korpi, Esa R., Quinlan, Joseph J., Firestone, Leonard L., Mi, Zhi-Ping, ...
γ-Aminobutyric acid (GABA) type A receptors mediate fast inhibitory synaptic transmission and have been implicated in responses to sedative/hypnotic agents (including neuroactive steroids), anxiety,...
Li, Hong Hua, Yu, Wei-Hong, Rozengurt, Nora, Zhao, Hui-Zhi, Lyons, Karen M., Anagnostaras, Stephan, ...
The Sanfilippo syndrome type B is an autosomal recessive disorder caused by mutation in the gene (NAGLU) encoding α-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation...
Trace but not delay fear conditioning requires attention and the anterior cingulate cortex
Han, C. J., O'Tuathaigh, Colm M., Van Trigt, Laurent, Quinn, Jennifer J., Fanselow, Michael S., Mongeau, Raymond, ...
Higher cognitive functions such as attention have been difficult to model in genetically tractable organisms. In humans, attention-distracting stimuli interfere with trace but not delay conditioning,...
Trace fear conditioning is enhanced in mice lacking the δ subunit of the GABAA receptor
Wiltgen, Brian J., Sanders, Matthew J., Ferguson, Carolyn, Homanics, Gregg E., Fanselow, Michael S.
The δ subunit of the GABAA receptor (GABAAR) is highly expressed in the dentate gyrus of the hippocampus. Genetic deletion of this subunit reduces synaptic and extrasynaptic inhibition and decreases...
Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice
Kim, Jeansok J., Shih, Jean C., Chen, Kevin, Chen, Lu, Bao, Shaowen, Maren, Stephen, ...
Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex,...
Mihalek, Robert M., Banerjee, Pradeep K., Korpi, Esa R., Quinlan, Joseph J., Firestone, Leonard L., Mi, Zhi-Ping, ...
γ-Aminobutyric acid (GABA) type A receptors mediate fast inhibitory synaptic transmission and have been implicated in responses to sedative/hypnotic agents (including neuroactive steroids), anxiety,...
Li, Hong Hua, Yu, Wei-Hong, Rozengurt, Nora, Zhao, Hui-Zhi, Lyons, Karen M., Anagnostaras, Stephan, ...
The Sanfilippo syndrome type B is an autosomal recessive disorder caused by mutation in the gene (NAGLU) encoding α-N-acetylglucosaminidase, a lysosomal enzyme required for the stepwise degradation...
Trace but not delay fear conditioning requires attention and the anterior cingulate cortex
Han, C. J., O'Tuathaigh, Colm M., Van Trigt, Laurent, Quinn, Jennifer J., Fanselow, Michael S., Mongeau, Raymond, ...
Higher cognitive functions such as attention have been difficult to model in genetically tractable organisms. In humans, attention-distracting stimuli interfere with trace but not delay conditioning,...
Trace fear conditioning is enhanced in mice lacking the δ subunit of the GABAA receptor
Wiltgen, Brian J., Sanders, Matthew J., Ferguson, Carolyn, Homanics, Gregg E., Fanselow, Michael S.
The δ subunit of the GABAA receptor (GABAAR) is highly expressed in the dentate gyrus of the hippocampus. Genetic deletion of this subunit reduces synaptic and extrasynaptic inhibition and decreases...
Blaeser, Frank, Sanders, Matthew J., Truong, Nga, Ko, Shanelle, Wu, Long Jun, Wozniak, David F., ...
Signaling by the Ca2+/calmodulin kinase (CaMK) cascade has been implicated in neuronal gene transcription, synaptic plasticity, and long-term memory consolidation. The CaM kinase kinase α (CaMKKα)...
A High Through-Put Reverse Genetic Screen Identifies Two Genes Involved in Remote Memory in Mice
Matynia, Anna, Anagnostaras, Stephan G., Wiltgen, Brian J., Lacuesta, Maress, Fanselow, Michael S., Silva, Alcino J.
Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational mechanisms. In contrast, very little is known...
Wiltgen, Brian J., Godsil, Bill P., Peng, Zechun, Saab, Faysal, June, Harry L., Linn, Michael L. Van, ...
Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation...