The involvement of replication in single stranded oligonucleotide-mediated gene repair (2006)
Huen, Michael S. Y., Li, Xin-tian, Lu, Lin-Yu, Watt, Rory M., Liu, De-Pei, Huang, Jian-Dong
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this...
The involvement of replication in single stranded oligonucleotide-mediated gene repair (2006)
Huen, Michael S. Y., Li, Xin-tian, Lu, Lin-Yu, Watt, Rory M., Liu, De-Pei, Huang, Jian-Dong
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this...
The involvement of replication in single stranded oligonucleotide-mediated gene repair (2006)
Huen, Michael S. Y., Li, Xin-tian, Lu, Lin-Yu, Watt, Rory M., Liu, De-Pei, Huang, Jian-Dong
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this...
The involvement of replication in single stranded oligonucleotide-mediated gene repair
Huen, Michael S. Y., Li, Xin-tian, Lu, Lin-Yu, Watt, Rory M., Liu, De-Pei, Huang, Jian-Dong
Targeted gene repair mediated by single-stranded oligonucleotides (SSOs) has great potential for use in functional genomic studies and gene therapy. Genetic changes have been created using this...
Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis
Minter-Dykhouse, Katherine, Ward, Irene, Huen, Michael S.Y., Chen, Junjie, Lou, Zhenkun
The importance of the DNA damage response (DDR) pathway in development, genomic stability, and tumor suppression is well recognized. Although 53BP1 and MDC1 have been recently identified as critical...
Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly▿ †
Huen, Michael S. Y., Huang, Jun, Yuan, Jingsong, Yamamoto, Masahiro, Akira, Shizuo, Ashley, Carolyn, ...
The E2 ubiquitin-conjugating enzyme UBC13 plays pivotal roles in diverse biological processes. Recent studies have elucidated that UBC13, in concert with the E3 ubiquitin ligase RNF8, propagates the...
Huen, Michael S. Y., Sy, Shirley M.-H., Van Deursen, Jan M., Chen, Junjie
Chromatin endowed by histone modifications governs chromatin structure, which in turn represents a means to regulate cellular processes, including transcription and heterochromatin formation. Recent...
Histone Ubiquitination Associates with BRCA1-Dependent DNA Damage Response▿ †
Wu, Jiaxue, Huen, Michael S. Y., Lu, Lin-Yu, Ye, Lin, Dou, Yali, Ljungman, Mats, ...
Histone ubiquitination participates in multiple cellular processes, including the DNA damage response. However, the molecular mechanisms involved are not clear. Here, we have identified that...
PALB2 is an integral component of the BRCA complex required for homologous recombination repair
Sy, Shirley M. H., Huen, Michael S. Y., Chen, Junjie
Mutations in breast cancer susceptibility gene 1 and 2 (BRCA1 and BRCA2) predispose individuals to breast and ovarian cancer development. We previously reported an in vivo interaction between BRCA1...