Michael Wyand

Simian immunodeficiency virus DNA vaccine trial in macaques (1996)

Lu, Shan, Arthos, James, Montefiori, David C., Yasutomi, Yasuhiro, Manson, Kelledy, Mustafa, Farah, ...

An experimental vaccine consisting of five DNA plasmids expressing different combinations and forms of simian immunodeficiency virus-macaque (SIVmac) proteins has been evaluated for the ability to...

DNA vaccines (1996)

Robinson, Harriet L., Lu, Shan, Feltquate, David Marc, Torres, Celia Aurora Tiglao, Richmond, Joann M., Boyle, Christine Margaret, ...

Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys (1996)

Yasutomi, Yasuhiro, Robinson, Harriet L., Lu, Shan, Mustafa, Farah, Lekutis, Christine, Arthos, James, ...

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected...

Simian Immunodeficiency Virus (SIV) gag DNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection

Egan, Michael A., Charini, William A., Kuroda, Marcelo J., Schmitz, Jörn E., Racz, Paul, Tenner-Racz, Klara, ...

The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the simian immunodeficiency virus (SIV)/macaque model of AIDS. Making use of soluble...

Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine

Voss, Gerald, Manson, Kelledy, Montefiori, David, Watkins, David I., Heeney, Jonathan, Wyand, Michael, ...

Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing...

Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques

Abdel-Motal, Ussama M., Gillis, Jacqueline, Manson, Kelledy, Wyand, Michael, Montefiori, David, Stefano-Cole, Kelly, ...

The ability of memory T cells to mount a recall response plays a key role in the ability of vaccinated animals to contain viral challenge. In this study, we intensively monitored the expansion of SIV...

Simian Immunodeficiency Virus (SIV) gag DNA-Vaccinated Rhesus Monkeys Develop Secondary Cytotoxic T-Lymphocyte Responses and Control Viral Replication after Pathogenic SIV Infection

Egan, Michael A., Charini, William A., Kuroda, Marcelo J., Schmitz, Jörn E., Racz, Paul, Tenner-Racz, Klara, ...

The potential contribution of a plasmid DNA construct to vaccine-elicited protective immunity was explored in the simian immunodeficiency virus (SIV)/macaque model of AIDS. Making use of soluble...

Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine

Voss, Gerald, Manson, Kelledy, Montefiori, David, Watkins, David I., Heeney, Jonathan, Wyand, Michael, ...

Recombinant protein subunit AIDS vaccines have been based predominantly on the virus envelope protein. Such vaccines elicit neutralizing antibody responses that can provide type-specific sterilizing...