Michel Chignard

Aspergillus fumigatus-induced IL-8 synthesis by respiratory epithelial cells is controlled by the PI3 kinase, p38 MAPK and ERK1/2 pathways and not by the TLR-MYD88 pathway. (2008)

Balloy, Viviane, Sallenave, Jean-Michel, Wu, Yongzheng, Touqui, Lhousseine, Latgé, Jean-Paul, Si-Tahar, Mustapha, ...

Previous studies have established that phagocytes are key cells of the pulmonary innate immune defense against A. fumigatus, an opportunistic fungus responsible of invasive pulmonary aspergillosis....

Aspergillus fumigatus-induced IL-8 synthesis by respiratory epithelial cells is controlled by the PI3 kinase, p38 MAPK and ERK1/2 pathways and not by the TLR-MYD88 pathway. (2008)

Balloy, Viviane, Sallenave, Jean-Michel, Wu, Yongzheng, Touqui, Lhousseine, Latgé, Jean-Paul, Si-Tahar, Mustapha, ...

Previous studies have established that phagocytes are key cells of the pulmonary innate immune defense against A. fumigatus, an opportunistic fungus responsible of invasive pulmonary aspergillosis....

Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin. (2008)

Ramphal, Reuben, Balloy, Viviane, Jyot, Jeevan, Verma, Amrisha, Si-Tahar, Mustapha, Chignard, Michel

Acute lung infection due to Pseudomonas aeruginosa is an increasingly serious problem that results in high mortality especially in the compromised host. In this study, we set out to ascertain what...

Control of Pseudomonas aeruginosa in the Lung Requires the Recognition of Either Lipopolysaccharide or Flagellin. (2008)

Ramphal, Reuben, Balloy, Viviane, Jyot, Jeevan, Verma, Amrisha, Si-Tahar, Mustapha, Chignard, Michel

Acute lung infection due to Pseudomonas aeruginosa is an increasingly serious problem that results in high mortality especially in the compromised host. In this study, we set out to ascertain what...

Aspergillus fumigatus-induced IL-8 synthesis by respiratory epithelial cells is controlled by the PI3 kinase, p38 MAPK and ERK1/2 pathways and not by the TLR-MYD88 pathway. (2008)

Balloy, Viviane, Sallenave, Jean-Michel, Wu, Yongzheng, Touqui, Lhousseine, Latgé, Jean-Paul, Si-Tahar, Mustapha, ...

Previous studies have established that phagocytes are key cells of the pulmonary innate immune defense against A. fumigatus, an opportunistic fungus responsible of invasive pulmonary aspergillosis....

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. (2007)

Chignard, Michel, Balloy, Viviane, Sallenave, Jean-Michel, Si-Tahar, Mustapha

Toll-like receptors are key to pathogen recognition by a host and to the subsequent triggering of an innate immune response. Experimental and clinical evidence shows that defects in Toll-like...

Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. (2007)

Chignard, Michel, Balloy, Viviane, Sallenave, Jean-Michel, Si-Tahar, Mustapha

Toll-like receptors are key to pathogen recognition by a host and to the subsequent triggering of an innate immune response. Experimental and clinical evidence shows that defects in Toll-like...

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. (2007)

Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts. (2007)

Chignard, Michel, Balloy, Viviane, Sallenave, Jean-Michel, Si-Tahar, Mustapha

Toll-like receptors are key to pathogen recognition by a host and to the subsequent triggering of an innate immune response. Experimental and clinical evidence shows that defects in Toll-like...

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia (2006)

Ronan Le Goffic, Viviane Balloy, Micheline Lagranderie, Lena Alexopoulou, Nicolas Escriou, Richard Flavell, ...

Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...

Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

Le-Barillec, Karine, Si-Tahar, Mustapha, Balloy, Viviane, Chignard, Michel

Human leukocyte elastase (HLE), a polymorphonuclear neutrophil (PMN) serine proteinase, is proteolytically active on some membrane receptors at the surface of immune cells. The present study focused...

Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis

Balloy, Viviane, Huerre, Michel, Latgé, Jean-Paul, Chignard, Michel

Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of...

Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice

González-Zorn, Bruno, Senna, Jose P. M., Fiette, Laurence, Shorte, Spencer, Testard, Aurélie, Chignard, Michel, ...

Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S....

Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis

Balloy, Viviane, Si-Tahar, Mustapha, Takeuchi, Osamu, Philippe, Bruno, Nahori, Marie-Anne, Tanguy, Myriam, ...

Aspergillus fumigatus, an opportunistic fungal pathogen, causes severe and usually fatal invasive pulmonary aspergillosis in immunocompromised hosts. Interestingly, Drosophila cells lacking the Toll...

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

Goffic, Ronan Le, Balloy, Viviane, Lagranderie, Micheline, Alexopoulou, Lena, Escriou, Nicolas, Flavell, Richard, ...

Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...

Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

Le-Barillec, Karine, Si-Tahar, Mustapha, Balloy, Viviane, Chignard, Michel

Human leukocyte elastase (HLE), a polymorphonuclear neutrophil (PMN) serine proteinase, is proteolytically active on some membrane receptors at the surface of immune cells. The present study focused...

Differences in Patterns of Infection and Inflammation for Corticosteroid Treatment and Chemotherapy in Experimental Invasive Pulmonary Aspergillosis

Balloy, Viviane, Huerre, Michel, Latgé, Jean-Paul, Chignard, Michel

Aspergillus fumigatus causes invasive pulmonary aspergillosis (IPA). This disease is one of the most life-threatening opportunistic infections in immunocompromised patients. The type of...

Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice

González-Zorn, Bruno, Senna, Jose P. M., Fiette, Laurence, Shorte, Spencer, Testard, Aurélie, Chignard, Michel, ...

Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S....

Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis

Balloy, Viviane, Si-Tahar, Mustapha, Takeuchi, Osamu, Philippe, Bruno, Nahori, Marie-Anne, Tanguy, Myriam, ...

Aspergillus fumigatus, an opportunistic fungal pathogen, causes severe and usually fatal invasive pulmonary aspergillosis in immunocompromised hosts. Interestingly, Drosophila cells lacking the Toll...

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

Goffic, Ronan Le, Balloy, Viviane, Lagranderie, Micheline, Alexopoulou, Lena, Escriou, Nicolas, Flavell, Richard, ...

Influenza A virus (IAV) is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. Recently, we demonstrated, using an in...

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system

Boneca, Ivo G., Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...

Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....

The Pseudomonas aeruginosa LasB Metalloproteinase Regulates the Human Urokinase-Type Plasminogen Activator Receptor through Domain-Specific Endoproteolysis▿

Leduc, Dominique, Beaufort, Nathalie, De Bentzmann, Sophie, Rousselle, Jean-Claude, Namane, Abdelkader, Chignard, Michel, ...

Pseudomonas aeruginosa is an opportunistic pathogen in human lungs, where its secretable LasB metalloproteinase can be a virulence factor. The urokinase-type plasminogen activator receptor (uPAR)...

Effects of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung

Singer, Monique, Boris Vargaftig, B, Chignard, Michel

Our previous work demonstrated that bacterial lipopolysaccharide (LPS), administered by aerosol, induced tumour necrosis factor (TNF-α) synthesis leading to the infiltration of neutrophils into mice...

Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway*

Balloy, Viviane, Sallenave, Jean-Michel, Wu, Yongzheng, Touqui, Lhousseine, Latgé, Jean-Paul, Si-Tahar, Mustapha, ...

Previous studies have established that phagocytes are key cells of the pulmonary innate immune defense against A. fumigatus, an opportunistic fungus responsible of invasive pulmonary aspergillosis....