Immunointervention for patients with HIV and tuberculosis (2009)
Vani, Janakiraman, Bansai, Kushagra, Kazatchkine, Michel D, Kaveri, Srini V, Bayry, Jagadeesh
Therapeutic options aimed at confronting the HIV pandemic face many obstacles. Current opinion on HIV-induced pathogenic immune activation and strategies aimed at eliminating HIV, including a...
Bayry, Jagadeesh, Bansal, Kushagra, Kazatchkine, Michel D, Kaveri, Srini V
Intravenous immunoglobulin (IVIg) is widely used to treat autoimmune diseases. Several mutually nonexclusive mechanisms are proposed to explain the beneficial effects of IVIg in patients (1, 2)....
Elluru, Sri, Van Huyen, Jean-Paul, Delignat, Sandrine, Kazatchkine, Michel D, Friboulet, Alain, Kaveri, Srini V, ...
Abstract Background Viscum album (VA) preparations have been used as a complimentary therapy in cancer. In addition to their cytotoxic properties, they have also been shown to have immunostimulatory...
Catalytic IgG from Patients with Hemophilia A Inactivate Therapeutic Factor VIII (2006)
Lacroix-Desmazes, Sebastien, Bharath, Wootla, Dasgupta, Suryasarathi, Sandrine, Delignat, Bayry, Jagadeesh, Reinbolt, Joseph, ...
Factor VIII (FVIII) inhibitors are anti-FVIII IgG that arise in up to 50% of the patients with hemophilia A, upon therapeutic administration of exogenous FVIII. Factor VIII inhibitors neutralize the...
Catalytic IgG from Patients with Hemophilia A Inactivate Therapeutic Factor VII (2006)
Lacroix-Desmazes, Sebastien, Wootla, Bharath, Dasgupta, Suryasarathi, Delignat, Sandrine, Bayry, Jagadeesh, Reinbolt, Joseph, ...
Factor VIII (FVIII) inhibitors are anti-FVIII IgG that arise in up to 50% of the patients with hemophilia A, upon therapeutic administration of exogenous FVIII. Factor VIII inhibitors neutralize the...
Physiopathology of catalytic antibodies:the case for factor VIII-hydrolyzing immunoglobulin G (2006)
Bharath, Wootla, Dasgupta, Suryasarathi, Mallet, Vincent, Kazatchkine, Michel D, Nagaraja, Valakunja, Friboulet, Alain, ...
Antibodies that are able to catalyze the antigen for which they are specific are produced spontaneously by the immune system. Catalytic immunoglobulins (Igs) both of the IgM and IgG isotypes have...
Varambally, Sooryanarayana, Bar-Dayan, Yaron, Bayry, Jagadeesh, Lacroix-Desmazes, Sébastien, Horn, Michael, Sorel, Marc, ...
Natural polyreactive IgM autoantibodies, encoded by unmutated germline Ig V genes, represent a major fraction of the normal circulating IgM repertoire. We have previously shown that therapeutic...
The prevalence of proteolytic antibodies against factor VIII in hemophilia A (2002)
Bayry, Jagadeesh, Misra, Namita, Horn, Michael P, Villard, Sylvie, Pashov, Anastas, ...
BACKGROUND: Factor VIII inhibitors are IgG alloantibodies that arise during replacement therapy in 25 to 50 percent of patients with severe hemophilia A. The hydrolysis of factor VIII by anti--factor...
The prevalence of proteolytic antibodies against factor VIII in hemophilia A (2002)
Bayry, Jagadeesh, Misra, Namita, Horn, Michael P, Villard, Sylvie, Pashov, Anastas, ...
BACKGROUND: Factor VIII inhibitors are IgG alloantibodies that arise during replacement therapy in 25 to 50 percent of patients with severe hemophilia A. The hydrolysis of factor VIII by anti--factor...
Fischer, Elizabeth M., Mouhoub, Amal, Maillet, Françoise, Frémeaux-Bacchi, Véronique, Krief, Corinne, Gould, Hannah, ...
CD21, the C3d/CD23/Epstein–Barr virus (EBV), receptor is expressed at low density on cells of the T lineage. Immature thymocytes express CD21 with high density. In the present study, we have...
Ronda, Nicoletta, Haury, Mattias, Nobrega, Alberto, Kaveri, Srinivas V., Coutinho, Antonio, Kazatchkine, Michel D.
The present study demonstrates that natural IgG with anti-endothelial cell activity is present in the serum of healthy individuals and in pooled normal human Ig. By using a novel method that allows...
Saoudi, Abdelhadi, Hurez, Vincent, De Kozak, Yvonne, Kuhn, Joelle, Kaveri, Srinivas V., Kazatchkine, Michel D., ...
We have evaluated the effect of human Igs for intravenous use (IVIg) on the onset and development of experimental autoimmune uveoretinitis (EAU), a T cell-dependent autoimmune disease induced in rats...
Si-Mohamed, Ali, Andreoletti, Laurent, Colombet, Isabelle, Carreno, Marie-Paule, Lopez, Gladys, Chatelier, Gilles, ...
Two commercially available hypersensitive assays for human immunodeficiency virus type 1 (HIV-1) RNA quantitation, AMPLICOR HIV-1 Monitor Test 1.5 and Quantiplex HIV RNA 3.0, were compared to detect...
Hocini, Hakim, Becquart, Pierre, Bouhlal, Hicham, Adle-Biassette, Homa, Kazatchkine, Michel D., Bélec, Laurent
In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral...
Chomont, Nicolas, Grésenguet, Gérard, Lévy, Michel, Hocini, Hakim, Becquart, Pierre, Matta, Mathieu, ...
The detection of traces of semen in cervicovaginal secretions (CVS) from sexually active women practicing unprotected sex is a prerequisite for the accurate study of cervicovaginal immunity. Two...
Bélec, Laurent, Mohamed, Ali Si, Müller-Trutwin, Michaela C., Gilquin, Jacques, Gutmann, Laurent, Safar, Michel, ...
A small number of cases of human immunodeficiency virus (HIV) infection have been reported in individuals with no identified risk factors for transmission. We report on the seroconversion of the...
Hocini, Hakim, Becquart, Pierre, Bouhlal, Hicham, Chomont, Nicolas, Ancuta, Petronela, Kazatchkine, Michel D., ...
We report that both primary and laboratory-adapted infectious human immunodeficiency virus type 1 (HIV-1) isolates in a cell-free form are capable of transcytosis through a tight and polarized...
Carreno, Marie-Paule, Chomont, Nicolas, Kazatchkine, Michel D., Irinopoulou, Theano, Krief, Corrine, Mohamed, Ali-Si, ...
Transmigration of human immunodeficiency virus (HIV)-infected mononuclear cells through the genital mucosa is one of the possible mechanisms of sexual transmission of HIV. Here, we investigated the...
Kazatchkine, Michel D., Fearon, Douglas T., Metcalfe, Dean D., Rosenberg, Robert D., Austen, K. Frank
The ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification C3 convertase is independent of antithrombin binding activity and requires substitution of the...
Natural antibodies sustain differentiation and maturation of human dendritic cells
Bayry, Jagadeesh, Lacroix-Desmazes, Sébastien, Donkova-Petrini, Vladimira, Carbonneil, Cédric, Misra, Namita, Lepelletier, Yves, ...
The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of...
High levels of catalytic antibodies correlate with favorable outcome in sepsis
Lacroix-Desmazes, Sébastien, Bayry, Jagadeesh, Kaveri, Srini V., Hayon-Sonsino, David, Thorenoor, Nithyananda, Charpentier, Julien, ...
Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic...
Si-Mohamed, Ali, Andreoletti, Laurent, Colombet, Isabelle, Carreno, Marie-Paule, Lopez, Gladys, Chatelier, Gilles, ...
Two commercially available hypersensitive assays for human immunodeficiency virus type 1 (HIV-1) RNA quantitation, AMPLICOR HIV-1 Monitor Test 1.5 and Quantiplex HIV RNA 3.0, were compared to detect...
Hocini, Hakim, Becquart, Pierre, Bouhlal, Hicham, Adle-Biassette, Homa, Kazatchkine, Michel D., Bélec, Laurent
In the present study, we demonstrate that recombinant human secretory leukocyte protease inhibitor (rhSLPI) inhibits infection of lymphocyte- and monocyte-derived tumor cell lines and peripheral...
Chomont, Nicolas, Grésenguet, Gérard, Lévy, Michel, Hocini, Hakim, Becquart, Pierre, Matta, Mathieu, ...
The detection of traces of semen in cervicovaginal secretions (CVS) from sexually active women practicing unprotected sex is a prerequisite for the accurate study of cervicovaginal immunity. Two...
Bélec, Laurent, Mohamed, Ali Si, Müller-Trutwin, Michaela C., Gilquin, Jacques, Gutmann, Laurent, Safar, Michel, ...
A small number of cases of human immunodeficiency virus (HIV) infection have been reported in individuals with no identified risk factors for transmission. We report on the seroconversion of the...
Hocini, Hakim, Becquart, Pierre, Bouhlal, Hicham, Chomont, Nicolas, Ancuta, Petronela, Kazatchkine, Michel D., ...
We report that both primary and laboratory-adapted infectious human immunodeficiency virus type 1 (HIV-1) isolates in a cell-free form are capable of transcytosis through a tight and polarized...
Carreno, Marie-Paule, Chomont, Nicolas, Kazatchkine, Michel D., Irinopoulou, Theano, Krief, Corrine, Mohamed, Ali-Si, ...
Transmigration of human immunodeficiency virus (HIV)-infected mononuclear cells through the genital mucosa is one of the possible mechanisms of sexual transmission of HIV. Here, we investigated the...
Kazatchkine, Michel D., Fearon, Douglas T., Metcalfe, Dean D., Rosenberg, Robert D., Austen, K. Frank
The ability of heparin glycosaminoglycan to prevent formation of the properdin-stabilized amplification C3 convertase is independent of antithrombin binding activity and requires substitution of the...
Natural antibodies sustain differentiation and maturation of human dendritic cells
Bayry, Jagadeesh, Lacroix-Desmazes, Sébastien, Donkova-Petrini, Vladimira, Carbonneil, Cédric, Misra, Namita, Lepelletier, Yves, ...
The differentiation and maturation of dendritic cells (DCs) is governed by various signals in the microenvironment. Monocytes and DCs circulate in peripheral blood, which contains high levels of...
High levels of catalytic antibodies correlate with favorable outcome in sepsis
Lacroix-Desmazes, Sébastien, Bayry, Jagadeesh, Kaveri, Srini V., Hayon-Sonsino, David, Thorenoor, Nithyananda, Charpentier, Julien, ...
Sepsis is the leading cause of death in intensive care units and results from a deleterious systemic host response to infection. Although initially perceived as potentially deleterious, catalytic...
Bayry, Jagadeesh, Delignat, Sandrine, Gaston, Anh Thu, Michel, Odile, Bruneval, Patrick, ...
BACKGROUND: Viscum album (VA) preparations consist of aqueous extracts of different types of lectins of VA. Mistletoe lectins have both cytotoxic and immunomodulatory properties that support their...
Dasgupta, Suryasarathi, Navarrete, Ana-Maria, Bayry, Jagadeesh, Delignat, Sandrine, Wootla, Bharath, André, Sébastien, ...
Several therapeutic self-proteins elicit immune responses when administered to patients. Such adverse immune responses reduce drug efficacy. To induce an immune response, a protein must interact with...
Elluru, Sri Ramulu, Delignat, Sandrine, Kazatchkine, Michel D, Friboulet, Alain, Kaveri, Srini V, ...
Bayry, Jagadeesh, Tchilian, Elma Z., Davies, Matthew N., Forbes, Emily K., Draper, Simon J., Kaveri, Srini V., ...
Adjuvants are substances that enhance immune responses and thus improve the efficacy of vaccination. Few adjuvants are available for use in humans, and the one that is most commonly used (alum) often...
Requena, Mary, Bouhlal, Hicham, Nasreddine, Nadine, Saidi, Hela, Gody, Jean-Chrysostome, Aubry, Sylvie, ...
The present study demonstrates that human breast milk and normal human polyclonal immunoglobulins purified from plasma [intravenous immunoglobulins (IVIg)] contain functional natural immunoglobulin A...