Michel Lagarde

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation. (2009)

Zeiller, Caroline, Mebarek, Saïda, Jaafar, Rami, Pirola, Luciano, Lagarde, Michel, Prigent, Annie-France, ...

Endothelial permeability is controlled by adhesive strengths which connect cells to each other through interendothelial junctions and by contractile forces associated with cytoskeleton...

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation. (2009)

Zeiller, Caroline, Mebarek, Saïda, Jaafar, Rami, Pirola, Luciano, Lagarde, Michel, Prigent, Annie-France, ...

Endothelial permeability is controlled by adhesive strengths which connect cells to each other through interendothelial junctions and by contractile forces associated with cytoskeleton...

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation. (2009)

Zeiller, Caroline, Mebarek, Saïda, Jaafar, Rami, Pirola, Luciano, Lagarde, Michel, Prigent, Annie-France, ...

Endothelial permeability is controlled by adhesive strengths which connect cells to each other through interendothelial junctions and by contractile forces associated with cytoskeleton...

Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men. (2009)

Calzada, Catherine, Colas, Romain, Guillot, Nicolas, Guichardant, Michel, Laville, Martine, Véricel, Evelyne, ...

OBJECTIVE: To determine the effect of supplementation with increasing doses of docosahexaenoic acid (DHA), as the only n-3 polyunsaturated fatty acid (PUFA), on low-density lipoprotein (LDL) redox...

Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men. (2009)

Calzada, Catherine, Colas, Romain, Guillot, Nicolas, Guichardant, Michel, Laville, Martine, Véricel, Evelyne, ...

OBJECTIVE: To determine the effect of supplementation with increasing doses of docosahexaenoic acid (DHA), as the only n-3 polyunsaturated fatty acid (PUFA), on low-density lipoprotein (LDL) redox...

Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men. (2009)

Calzada, Catherine, Colas, Romain, Guillot, Nicolas, Guichardant, Michel, Laville, Martine, Véricel, Evelyne, ...

OBJECTIVE: To determine the effect of supplementation with increasing doses of docosahexaenoic acid (DHA), as the only n-3 polyunsaturated fatty acid (PUFA), on low-density lipoprotein (LDL) redox...

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. (2009)

Chen, Ping, Fenet, Bernard, Michaud, Sabine, Tomczyk, Nick, Véricel, Evelyne, Lagarde, Michel, ...

Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of...

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. (2009)

Chen, Ping, Fenet, Bernard, Michaud, Sabine, Tomczyk, Nick, Véricel, Evelyne, Lagarde, Michel, ...

Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of...

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. (2009)

Chen, Ping, Fenet, Bernard, Michaud, Sabine, Tomczyk, Nick, Véricel, Evelyne, Lagarde, Michel, ...

Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of...

Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation. (2009)

Chen, Ping, Fenet, Bernard, Michaud, Sabine, Tomczyk, Nick, Véricel, Evelyne, Lagarde, Michel, ...

Our study aimed to establish the complete structure of the main dihydroxy conjugated triene issued from the lipoxygenation (soybean enzyme) of docosahexaenoic acid, named PDX, an isomer of...

Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers. (2008)

Stanke-Labesque, Françoise, Molière, Patrick, Bessard, Jeanine, Laville, Martine, Véricel, Evelyne, Lagarde, Michel

n-3 PUFA supplementation helps in the prevention or treatment of inflammatory diseases and CVD. However, many supplementations reported so far are either a combination of n-3 PUFA or used large daily...

Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers. (2008)

Stanke-Labesque, Françoise, Molière, Patrick, Bessard, Jeanine, Laville, Martine, Véricel, Evelyne, Lagarde, Michel

n-3 PUFA supplementation helps in the prevention or treatment of inflammatory diseases and CVD. However, many supplementations reported so far are either a combination of n-3 PUFA or used large daily...

Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis. (2008)

Guillot, Nicolas, Debard, Cyrille, Calzada, Catherine, Vidal, Hubert, Lagarde, Michel, Véricel, Evelyne

Beneficial effects of docosahexaenoic acid (DHA) intake in the prevention of cardiovascular diseases are known, and platelets play a crucial role in cardiovascular complications. However, high doses...

Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis. (2008)

Guillot, Nicolas, Debard, Cyrille, Calzada, Catherine, Vidal, Hubert, Lagarde, Michel, Véricel, Evelyne

Beneficial effects of docosahexaenoic acid (DHA) intake in the prevention of cardiovascular diseases are known, and platelets play a crucial role in cardiovascular complications. However, high doses...

Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. (2008)

Mebarek, Saïda, Ermak, Natalia, Benzaria, Amal, Vicca, Stéphanie, Dubois, Madeleine, Némoz, Georges, ...

Dietary intake of long-chain n-3 PUFA has been reported to decrease several markers of lymphocyte activation and modulate monocyte susceptibility to apoptosis. However, most human studies examined...

Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. (2008)

Mebarek, Saïda, Ermak, Natalia, Benzaria, Amal, Vicca, Stéphanie, Dubois, Madeleine, Némoz, Georges, ...

Dietary intake of long-chain n-3 PUFA has been reported to decrease several markers of lymphocyte activation and modulate monocyte susceptibility to apoptosis. However, most human studies examined...

Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. (2008)

Mebarek, Saïda, Ermak, Natalia, Benzaria, Amal, Vicca, Stéphanie, Dubois, Madeleine, Némoz, Georges, ...

Dietary intake of long-chain n-3 PUFA has been reported to decrease several markers of lymphocyte activation and modulate monocyte susceptibility to apoptosis. However, most human studies examined...

Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis. (2008)

Guillot, Nicolas, Debard, Cyrille, Calzada, Catherine, Vidal, Hubert, Lagarde, Michel, Véricel, Evelyne

Beneficial effects of docosahexaenoic acid (DHA) intake in the prevention of cardiovascular diseases are known, and platelets play a crucial role in cardiovascular complications. However, high doses...

Effect of dietary supplementation with increasing doses of docosahexaenoic acid on neutrophil lipid composition and leukotriene production in human healthy volunteers. (2008)

Stanke-Labesque, Françoise, Molière, Patrick, Bessard, Jeanine, Laville, Martine, Véricel, Evelyne, Lagarde, Michel

n-3 PUFA supplementation helps in the prevention or treatment of inflammatory diseases and CVD. However, many supplementations reported so far are either a combination of n-3 PUFA or used large daily...

The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity. (2007)

Ibrahim, Salam, Calzada, Catherine, Pruneta-Deloche, Valérie, Lagarde, Michel, Ponsin, Gabriel

We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200...

The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity. (2007)

Ibrahim, Salam, Calzada, Catherine, Pruneta-Deloche, Valérie, Lagarde, Michel, Ponsin, Gabriel

We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200...

In vitro glycoxidized low-density lipoproteins and low-density lipoproteins isolated from type 2 diabetic patients activate platelets via p38 mitogen-activated protein kinase. (2007)

Calzada, Catherine, Coulon, Laurent, Halimi, Déborah, Le Coquil, Elodie, Pruneta-Deloche, Valérie, Moulin, Philippe, ...

CONTEXT: Platelet hyperactivation contributes to the increased risk for atherothrombosis in type 2 diabetes and is associated with oxidative stress. Plasma low-density lipoproteins (LDLs) are exposed...

In vitro glycoxidized low-density lipoproteins and low-density lipoproteins isolated from type 2 diabetic patients activate platelets via p38 mitogen-activated protein kinase. (2007)

Calzada, Catherine, Coulon, Laurent, Halimi, Déborah, Le Coquil, Elodie, Pruneta-Deloche, Valérie, Moulin, Philippe, ...

CONTEXT: Platelet hyperactivation contributes to the increased risk for atherothrombosis in type 2 diabetes and is associated with oxidative stress. Plasma low-density lipoproteins (LDLs) are exposed...

In vitro glycoxidized low-density lipoproteins and low-density lipoproteins isolated from type 2 diabetic patients activate platelets via p38 mitogen-activated protein kinase. (2007)

Calzada, Catherine, Coulon, Laurent, Halimi, Déborah, Le Coquil, Elodie, Pruneta-Deloche, Valérie, Moulin, Philippe, ...

CONTEXT: Platelet hyperactivation contributes to the increased risk for atherothrombosis in type 2 diabetes and is associated with oxidative stress. Plasma low-density lipoproteins (LDLs) are exposed...

The transfer of VLDL-associated phospholipids to activated platelets depends upon cytosolic phospholipase A2 activity. (2007)

Ibrahim, Salam, Calzada, Catherine, Pruneta-Deloche, Valérie, Lagarde, Michel, Ponsin, Gabriel

We previously reported that VLDL could transfer phospholipids (PLs) to activated platelets. To identify the metabolic pathway involved in this process, the transfer of radiolabeled PLs from VLDL (200...

Inhibition of de novo ceramide synthesis upregulates phospholipase D and enhances myogenic differentiation. (2007)

Mebarek, Saïda, Komati, Hiba, Naro, Fabio, Zeiller, Caroline, Alvisi, Monica, Lagarde, Michel, ...

In L6 skeletal myoblasts induced to differentiate by Arg8-vasopressin treatment, a short-lived lowering of ceramide levels was observed, followed by a long-lasting elevation that was prevented by...

Inhibition of de novo ceramide synthesis upregulates phospholipase D and enhances myogenic differentiation. (2007)

Mebarek, Saïda, Komati, Hiba, Naro, Fabio, Zeiller, Caroline, Alvisi, Monica, Lagarde, Michel, ...

In L6 skeletal myoblasts induced to differentiate by Arg8-vasopressin treatment, a short-lived lowering of ceramide levels was observed, followed by a long-lasting elevation that was prevented by...

Inhibition of de novo ceramide synthesis upregulates phospholipase D and enhances myogenic differentiation. (2007)

Mebarek, Saïda, Komati, Hiba, Naro, Fabio, Zeiller, Caroline, Alvisi, Monica, Lagarde, Michel, ...

In L6 skeletal myoblasts induced to differentiate by Arg8-vasopressin treatment, a short-lived lowering of ceramide levels was observed, followed by a long-lasting elevation that was prevented by...

Involvement of gangliosides in glucosamine-induced proliferation decrease of retinal pericytes (2005)

Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, El Bawab, Samer

The hexosamine pathway (HP) is a biochemical hypothesis recently proposed explaining cellular alterations occurring during diabetic microvascular complications. Diabetic retinopathy is a common...

Involvement of gangliosides in glucosamine-induced proliferation decrease of retinal pericytes (2004)

Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, Bawab, Samer El

The hexosamine pathway (HP) is a biochemical hypothesis recently proposed explaining cellular alterations occurring during diabetic microvascular complications. Diabetic retinopathy is a common...

Involvement of gangliosides in glucosamine-induced proliferation decrease of retinal pericytes (2004)

Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, Bawab, Samer El

The hexosamine pathway (HP) is a biochemical hypothesis recently proposed explaining cellular alterations occurring during diabetic microvascular complications. Diabetic retinopathy is a common...

Monohydroxylated Fatty Acid Content in Peripheral Blood Mononuclear Cells and Immune Status of People at Long Times after the Chernobyl Accident (2001)

Anatoliy Chumak, Chantal Thevenon, Nadya Gulaya, Michel Guichardant, Victor Margitich, Dimitry Bazyka, ...

Chumak, A., Thevenon, C., Gulaya, N., Guichardant, M., Margitich, V., Bazyka, D., Kovalenko, A., Lagarde, M. and Prigent, A. F. Monohydroxylated Fatty Acid Content in Peripheral Blood Mononuclear...

Involvement of Type 4 cAMP-Phosphodiesterase in the Myogenic Differentiation of L6 Cells

Naro, Fabio, Sette, Claudio, Vicini, Elena, De Arcangelis, Vania, Grange, Muriel, Conti, Marco, ...

Myogenic cell differentiation is induced by Arg8-vasopressin, whereas high cAMP levels and protein kinase A (PKA) activity inhibit myogenesis. We investigated the role of type 4 phosphodiesterase...

IGF-I–induced Differentiation of L6 Myogenic Cells Requires the Activity of cAMP-Phosphodiesterase

De Arcangelis, Vania, Coletti, Dario, Conti, Marco, Lagarde, Michel, Molinaro, Mario, Adamo, Sergio, ...

Inhibition of type 4 cAMP-specific phosphodiesterase (PDE4) activity in L6-C5 and L6-E9 abolished myogenic differentiation induced by low-serum medium and IGF-I. L6-C5 cells cultured in low-serum...

Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides

Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, Bawab, Samer El

Alterations in proliferation and hypertrophy of renal mesangial cells are typical features of diabetic nephropathy. The HP (hexosamine pathway) has been proposed as a biochemical hypothesis to...

Phospholipase D Is Involved in Myogenic Differentiation through Remodeling of Actin Cytoskeleton

Komati, Hiba, Naro, Fabio, Mebarek, Saida, De Arcangelis, Vania, Adamo, Sergio, Lagarde, Michel, ...

We investigated the role of phospholipase D (PLD) and its product phosphatidic acid (PA) in myogenic differentiation of cultured L6 rat skeletal myoblasts. Arginine-vasopressin (AVP), a...

Involvement of Type 4 cAMP-Phosphodiesterase in the Myogenic Differentiation of L6 Cells

Naro, Fabio, Sette, Claudio, Vicini, Elena, De Arcangelis, Vania, Grange, Muriel, Conti, Marco, ...

Myogenic cell differentiation is induced by Arg8-vasopressin, whereas high cAMP levels and protein kinase A (PKA) activity inhibit myogenesis. We investigated the role of type 4 phosphodiesterase...

IGF-I–induced Differentiation of L6 Myogenic Cells Requires the Activity of cAMP-Phosphodiesterase

De Arcangelis, Vania, Coletti, Dario, Conti, Marco, Lagarde, Michel, Molinaro, Mario, Adamo, Sergio, ...

Inhibition of type 4 cAMP-specific phosphodiesterase (PDE4) activity in L6-C5 and L6-E9 abolished myogenic differentiation induced by low-serum medium and IGF-I. L6-C5 cells cultured in low-serum...

Phospholipase D Is Involved in Myogenic Differentiation through Remodeling of Actin Cytoskeleton

Komati, Hiba, Naro, Fabio, Mebarek, Saida, De Arcangelis, Vania, Adamo, Sergio, Lagarde, Michel, ...

We investigated the role of phospholipase D (PLD) and its product phosphatidic acid (PA) in myogenic differentiation of cultured L6 rat skeletal myoblasts. Arginine-vasopressin (AVP), a...

Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implication of gangliosides

Masson, Elodie, Wiernsperger, Nicolas, Lagarde, Michel, Bawab, Samer El

Alterations in proliferation and hypertrophy of renal mesangial cells are typical features of diabetic nephropathy. The HP (hexosamine pathway) has been proposed as a biochemical hypothesis to...

Mechanisms involved in the stimulation of prostacyclin synthesis by human lymphocytes in human umbilical vein endothelial cells

Merhi-Soussi, Faten, Dominguez, Zury, Macovschi, Olga, Dubois, Madeleine, Nemoz, Georges, Lagarde, Michel, ...

Endothelial cells play an important role in the modulation of vascular tone because of their ability to produce vasoactive substances such as prostacyclin (PGI2). Cell–cell contact between human...