Michelina Nascimbeni

Kinetics of Antiviral Activity and Intracellular Pharmacokinetics of Human Immunodeficiency Virus Type 1 Protease Inhibitors in Tissue Culture

Nascimbeni, Michelina, Lamotte, Claire, Peytavin, Gilles, Farinotti, Robert, Clavel, François

We have examined the kinetics of the inhibition of human immunodeficiency virus type 1 (HIV-1) particle infectivity by protease inhibitors (PIs) in cell culture, using either transfected HeLa cells...

Molecular and Immunological Significance of Chimpanzee Major Histocompatibility Complex Haplotypes for Hepatitis C Virus Immune Response and Vaccination Studies

Mizukoshi, Eishiro, Nascimbeni, Michelina, Blaustein, Joshua B., Mihalik, Kathleen, Rice, Charles M., Liang, T. Jake, ...

The chimpanzee is a critical animal model for studying cellular immune responses to infectious pathogens such as hepatitis B and C viruses, human immunodeficiency virus, and malaria. Several...

Previously Infected and Recovered Chimpanzees Exhibit Rapid Responses That Control Hepatitis C Virus Replication upon Rechallenge

Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...

Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...

The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity

Thomson, Michael, Nascimbeni, Michelina, Havert, Michael B., Major, Marian, Gonzales, Sophia, Alter, Harvey, ...

Clearance of hepatitis C virus (HCV) infection in humans and chimpanzees is thought to be associated with the induction of strong T-cell responses. We studied four chimpanzees infected with HCV...

Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...

The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...

Immunization with Hepatitis C Virus-Like Particles Induces Humoral and Cellular Immune Responses in Nonhuman Primates

Jeong, Sook-Hyang, Qiao, Ming, Nascimbeni, Michelina, Hu, Zongyi, Rehermann, Barbara, Murthy, Krishna, ...

We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing the cDNA of the HCV structural proteins (core, E1, and E2). These...

Kinetics of Antiviral Activity and Intracellular Pharmacokinetics of Human Immunodeficiency Virus Type 1 Protease Inhibitors in Tissue Culture

Nascimbeni, Michelina, Lamotte, Claire, Peytavin, Gilles, Farinotti, Robert, Clavel, François

We have examined the kinetics of the inhibition of human immunodeficiency virus type 1 (HIV-1) particle infectivity by protease inhibitors (PIs) in cell culture, using either transfected HeLa cells...

Molecular and Immunological Significance of Chimpanzee Major Histocompatibility Complex Haplotypes for Hepatitis C Virus Immune Response and Vaccination Studies

Mizukoshi, Eishiro, Nascimbeni, Michelina, Blaustein, Joshua B., Mihalik, Kathleen, Rice, Charles M., Liang, T. Jake, ...

The chimpanzee is a critical animal model for studying cellular immune responses to infectious pathogens such as hepatitis B and C viruses, human immunodeficiency virus, and malaria. Several...

Previously Infected and Recovered Chimpanzees Exhibit Rapid Responses That Control Hepatitis C Virus Replication upon Rechallenge

Major, Marian E., Mihalik, Kathleen, Puig, Montserrat, Rehermann, Barbara, Nascimbeni, Michelina, Rice, Charles M., ...

Responses in three chimpanzees were compared following challenge with a clonal hepatitis C virus (HCV) contained in plasma from an animal that had received infectious RNA transcripts. Two of the...

The Clearance of Hepatitis C Virus Infection in Chimpanzees May Not Necessarily Correlate with the Appearance of Acquired Immunity

Thomson, Michael, Nascimbeni, Michelina, Havert, Michael B., Major, Marian, Gonzales, Sophia, Alter, Harvey, ...

Clearance of hepatitis C virus (HCV) infection in humans and chimpanzees is thought to be associated with the induction of strong T-cell responses. We studied four chimpanzees infected with HCV...

Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees

Nascimbeni, Michelina, Mizukoshi, Eishiro, Bosmann, Markus, Major, Marian E., Mihalik, Kathleen, Rice, Charles M., ...

The immunological correlates of hepatitis C virus (HCV)-specific immunity are not well understood. Antibodies to HCV structural proteins do not appear to play a key role in clearance of the virus and...

Immunization with Hepatitis C Virus-Like Particles Induces Humoral and Cellular Immune Responses in Nonhuman Primates

Jeong, Sook-Hyang, Qiao, Ming, Nascimbeni, Michelina, Hu, Zongyi, Rehermann, Barbara, Murthy, Krishna, ...

We have previously reported the production of hepatitis C virus-like particles (HCV-LP) using a recombinant baculovirus containing the cDNA of the HCV structural proteins (core, E1, and E2). These...

A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes

Dasgupta, Suryasarathi, Navarrete, Ana-Maria, Bayry, Jagadeesh, Delignat, Sandrine, Wootla, Bharath, André, Sébastien, ...

Several therapeutic self-proteins elicit immune responses when administered to patients. Such adverse immune responses reduce drug efficacy. To induce an immune response, a protein must interact with...