Miguel Lafarga

LPS-induced down-regulation of NO-sensitive guanylyl cyclase in astrocytes occurs by proteasomal degradation in nuclear bodies (2007)

Berciano, María T., Baltrons, María Antonia, Pifarré, Paula, Lafarga, Miguel, García, Agustina

From 3rd International Conference on cGMP Generators, Effectors and Therapeutic Implications.-- This abstract is available from: http://www.biomedcentral.com/1471-2210/7/S1/P3

In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1 (2005)

TAVANEZ, JOÃO PAULO, CALADO, PATRICIA, BRAGA, JOSÉ, LAFARGA, MIGUEL, CARMO-FONSECA, MARIA

A broad range of degenerative diseases is associated with intracellular inclusions formed by toxic, aggregation-prone mutant proteins. Intranuclear inclusions constitute a pathological hallmark of...

In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1 (2005)

TAVANEZ, JOÃO PAULO, CALADO, PATRICIA, BRAGA, JOSÉ, LAFARGA, MIGUEL, CARMO-FONSECA, MARIA

A broad range of degenerative diseases is associated with intracellular inclusions formed by toxic, aggregation-prone mutant proteins. Intranuclear inclusions constitute a pathological hallmark of...

Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus (2004)

Berciano, Maria T., Villagra, Nuria T., Ojeda, Jose L., Navascues, Joaquin, Gomes, Anita, Lafarga, Miguel, ...

Intranuclear inclusions composed of tubular filaments constitute a pathological hallmark of oculopharyngeal muscular dystrophy (OPMD). Autosomal dominant OPMD is caused by (GCG) repeat expansions in...

Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus (2004)

Berciano, Maria T., Villagra, Nuria T., Ojeda, Jose L., Navascues, Joaquin, Gomes, Anita, Lafarga, Miguel, ...

Intranuclear inclusions composed of tubular filaments constitute a pathological hallmark of oculopharyngeal muscular dystrophy (OPMD). Autosomal dominant OPMD is caused by (GCG) repeat expansions in...

Oculopharyngeal muscular dystrophy-like nuclear inclusions are present in normal magnocellular neurosecretory neurons of the hypothalamus (2004)

Berciano, Maria T., Villagra, Nuria T., Ojeda, Jose L., Navascues, Joaquin, Gomes, Anita, Lafarga, Miguel, ...

Intranuclear inclusions composed of tubular filaments constitute a pathological hallmark of oculopharyngeal muscular dystrophy (OPMD). Autosomal dominant OPMD is caused by (GCG) repeat expansions in...

Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product. (2001)

Tucker, Karen E., Berciano, Maria Teresa, Jacobs, Erica Y., LePage, David F., Shpargel, Karl B., Rossire, Jennifer J., ...

Cajal bodies (CBs) are nuclear suborganelles involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs). In addition to snRNPs, they are highly enriched in basal transcription and cell...

Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome

Lafarga, Miguel, Berciano, Maria Teresa, Pena, Emma, Mayo, Isabel, Castaño, Jose G., Bohmann, Dirk, ...

Nuclear bodies represent a heterogeneous class of nuclear structures. Herein, we describe that a subset of nuclear bodies is highly enriched in components of the ubiquitin–proteasome pathway of...

Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors

Arozarena, Imanol, Matallanas, David, Berciano, María T., Sanz-Moreno, Victoria, Calvo, Fernando, Muñoz, María T., ...

Recent findings indicate that in addition to its location in the peripheral plasma membrane, H-Ras is found in endomembranes like the endoplasmic reticulum and the Golgi complex. In these locations...

In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1

TAVANEZ, JOÃO PAULO, CALADO, PATRICIA, BRAGA, JOSÉ, LAFARGA, MIGUEL, CARMO-FONSECA, MARIA

A broad range of degenerative diseases is associated with intracellular inclusions formed by toxic, aggregation-prone mutant proteins. Intranuclear inclusions constitute a pathological hallmark of...

Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome

Lafarga, Miguel, Berciano, Maria Teresa, Pena, Emma, Mayo, Isabel, Castaño, Jose G., Bohmann, Dirk, ...

Nuclear bodies represent a heterogeneous class of nuclear structures. Herein, we describe that a subset of nuclear bodies is highly enriched in components of the ubiquitin–proteasome pathway of...

Activation of H-Ras in the Endoplasmic Reticulum by the RasGRF Family Guanine Nucleotide Exchange Factors

Arozarena, Imanol, Matallanas, David, Berciano, María T., Sanz-Moreno, Victoria, Calvo, Fernando, Muñoz, María T., ...

Recent findings indicate that in addition to its location in the peripheral plasma membrane, H-Ras is found in endomembranes like the endoplasmic reticulum and the Golgi complex. In these locations...

In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1

TAVANEZ, JOÃO PAULO, CALADO, PATRICIA, BRAGA, JOSÉ, LAFARGA, MIGUEL, CARMO-FONSECA, MARIA

A broad range of degenerative diseases is associated with intracellular inclusions formed by toxic, aggregation-prone mutant proteins. Intranuclear inclusions constitute a pathological hallmark of...

Mxi2 promotes stimulus-independent ERK nuclear translocation

Casar, Berta, Sanz-Moreno, Victoria, Yazicioglu, Mustafa N, Rodríguez, Javier, Berciano, María T, Lafarga, Miguel, ...

Spatial regulation of ERK1/2 MAP kinases is an essential yet largely unveiled mechanism for ensuring the fidelity and specificity of their signals. Mxi2 is a p38α isoform with the ability to bind...

Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product

Tucker, Karen E., Berciano, Maria Teresa, Jacobs, Erica Y., LePage, David F., Shpargel, Karl B., Rossire, Jennifer J., ...

Cajal bodies (CBs) are nuclear suborganelles involved in the biogenesis of small nuclear ribonucleoproteins (snRNPs). In addition to snRNPs, they are highly enriched in basal transcription and cell...

Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling

Pálmer, Héctor G., González-Sancho, José Manuel, Espada, Jesús, Berciano, María T., Puig, Isabel, Baulida, Josep, ...

The β-catenin signaling pathway is deregulated in nearly all colon cancers. Nonhypercalcemic vitamin D3 (1α,25-dehydroxyvitamin D3) analogues are candidate drugs to treat this neoplasia. We show...

The Spinal Muscular Atrophy Disease Gene Product, Smn: A Link between Snrnp Biogenesis and the Cajal (Coiled) Body

Carvalho, Teresa, Almeida, Fátima, Calapez, Alexandre, Lafarga, Miguel, Berciano, Maria T., Carmo-Fonseca, Maria

The spliceosomal snRNAs U1, U2, U4, and U5 are synthesized in the nucleus, exported to the cytoplasm to assemble with Sm proteins, and reimported to the nucleus as ribonucleoprotein particles....

Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution

González, María Victoria, Jiménez, Benilde, Berciano, María T., González-Sancho, José Manuel, Caelles, Carme, Lafarga, Miguel, ...

The immunosuppressive and antiinflammatory actions of glucocorticoid hormones are mediated by their transrepression of activating protein-1 (AP-1) and nuclear factor-kappa B (NFκB) transcription...

RhoA–ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells

Ordóñez-Morán, Paloma, Larriba, María Jesús, Pálmer, Héctor G., Valero, Ruth A., Barbáchano, Antonio, Duñach, Mireia, ...

The active vitamin D metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) inhibits proliferation and promotes differentiation of colon cancer cells through the activation of vitamin D receptor (VDR), a...

Hsp70 Chaperones and Type I PRMTs Are Sequestered at Intranuclear Inclusions Caused by Polyalanine Expansions in PABPN1

Tavanez, João Paulo, Bengoechea, Rocio, Berciano, Maria T., Lafarga, Miguel, Carmo-Fonseca, Maria, Enguita, Francisco J.

Genomic instability at loci with tandem arrays of simple repeats is the cause for many neurological, neurodegenerative and neuromuscular diseases. When located in coding regions, disease-associated...