Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver (2007)
Okumura, Hirotoshi, Katoh, Miki, Sawada, Toshiro, Nakajima, Miki, Soeno, Yoshinori, Yabuuchi, Hikaru, ...
The liver of a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human...
Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver (2007)
Okumura, Hirotoshi, Katoh, Miki, Sawada, Toshiro, Nakajima, Miki, Soeno, Yoshinori, Yabuuchi, Hikaru, ...
The liver of a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodificient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human...
Nakajima, Miki, Fukami, T., Yamanaka, H., Higashi, E., Sakai, H., Yoshida, R., ...
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine and is a possible modulator of nicotine addiction. Quantitative and qualitative differences in nicotine addiction have been observed...
Komagata, Sayaka, Nakajima, Miki, Tsuchiya, Yuki, Katoh, Miki, Kizu, Ryoichi, Kyo, Satoru, ...
Estrogen receptor α (ERα) is a ligand-inducible transcription factor that mediates the biological effects of estrogens and antiestrogens. Many point mutations in the human ERα gene have been...
Tsuchiya, Yuki, Nakajima, Miki, Takagi, Shingo, Katoh, Miki, Zheng, Wenchao, Jefcoate, Colin R, ...
Cytochrome P450 (CYP) 1B1, which catalyzes 17β-estradiol 4-hydroxylation, is expressed in steroid-related tissues including ovary, testis, and adrenal gland. Generally, the expressions of...
Minami, Keiichi, Saito, Toshiro, Narahara, Masatoshi, Tomita, Hiroyuki, Kato, Hirokazu, Sugiyama, Hisashi, ...
In the field of gene expression analysis, DNA microarray technology has a major impact on many different areas including toxicogenomics, such as in predicting the adverse effects of new drug...
Chaperone Proteins Involved in Troglitazone-Induced Toxicity in Human Hepatoma Cell Lines (2005)
Maniratanachote, Rawiwan, Minami, Keiichi, Katoh, Miki, Nakajima, Miki, Yokoi, Tsuyoshi
Troglitazone (TRO), an effective thiazolidinedione antidiabetic agent, was reported to produce idiosyncratic hepatotoxic effects in some individuals. In contrast, rosiglitazone (RSG), in the same...
Minami, Keiichi, Saito, Toshiro, Narahara, Masatoshi, Tomita, Hiroyuki, Kato, Hirokazu, Sugiyama, Hisashi, ...
In the field of gene expression analysis, DNA microarray technology has a major impact on many different areas including toxicogenomics, such as in predicting the adverse effects of new drug...
Chaperone Proteins Involved in Troglitazone-Induced Toxicity in Human Hepatoma Cell Lines (2004)
Maniratanachote, Rawiwan, Minami, Keiichi, Katoh, Miki, Nakajima, Miki, Yokoi, Tsuyoshi
Troglitazone (TRO), an effective thiazolidinedione antidiabetic agent, was reported to produce idiosyncratic hepatotoxic effects in some individuals. In contrast, rosiglitazone (RSG), in the same...
Tsuchiya, Yuki, Nakajima, Miki, Itoh, Satsuki, Iwanari, Masashi, Yokoi, Tsuyoshi
Aryl hydrocarbon receptor repressor (AhRR) has been recently identified as a negative factor that suppresses aryl hydrocarbon receptor (AhR)-mediated transcriptional gene expression. In the present...
Critical Enhancer Region to Which AhR/ARNT and Sp1 Bind in the Human CYP1B1 Gene (2003)
Tsuchiya, Yuki, Nakajima, Miki, Yokoi, Tsuyoshi
Cytochrome P450 (CYP) 1B1 is known to be induced by polycyclic aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The constitutive and TCDD-inducible transcriptional...
Tsuchiya, Yuki, Nakajima, Miki, Itoh, Satsuki, Iwanari, Masashi, Yokoi, Tsuyoshi
Aryl hydrocarbon receptor repressor (AhRR) has been recently identified as a negative factor that suppresses aryl hydrocarbon receptor (AhR)-mediated transcriptional gene expression. In the present...
Tsuchiya, Yuki, Nakajima, Miki, Itoh, Satsuki, Iwanari, Masashi, Yokoi, Tsuyoshi
Aryl hydrocarbon receptor repressor (AhRR) has been recently identified as a negative factor that suppresses aryl hydrocarbon receptor (AhR)-mediated transcriptional gene expression. In the present...
Induction of cytochrome P450 1B1 in lung, liver and kidney of rats exposed to diesel exhaust (2001)
Hatanaka, Naoya, Yamazaki, Hiroshi, Kizu, Ryoichi, Hayakawa, Kazuichi, Aoki, Yasunobu, Iwanari, Masashi, ...
We have shown previously that diesel exhaust particle (DEP) extracts (DEPE) and 1-nitropyrene were genotoxically activated by human cytochrome P450 1B1 in SOS/umu assay. In this study, the in vivo...
Nakajima, Miki, Yokoi, Tsuyoshi, Mizutani, Mayumi, Kinoshitah, Moritoshi, Funayama, Masato, Kamataki, Tetsuya
A genetic polymorphism was identified in the 5′-flanking region of human CYP1A2 gene, and its effect on the transcriptional activation of the CYP1A2 gene was investigated. Nucleotide sequence...
Komagata, Sayaka, Nakajima, Miki, Tsuchiya, Yuki, Katoh, Miki, Kizu, Ryoichi, Kyo, Satoru, ...
Estrogen receptor α (ERα) is a ligand-inducible transcription factor that mediates the biological effects of estrogens and antiestrogens. Many point mutations in the human ERα gene have been...
Nakajima, Miki, Fukami, T., Yamanaka, H., Higashi, E., Sakai, H., Yoshida, R., ...
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine and is a possible modulator of nicotine addiction. Quantitative and qualitative differences in nicotine addiction have been observed...
Komagata, Sayaka, Nakajima, Miki, Tsuchiya, Yuki, Katoh, Miki, Kizu, Ryoichi, Kyo, Satoru, ...
Estrogen receptor α (ERα) is a ligand-inducible transcription factor that mediates the biological effects of estrogens and antiestrogens. Many point mutations in the human ERα gene have been...
Nakajima, Miki, Fukami, T., Yamanaka, H., Higashi, E., Sakai, H., Yoshida, R., ...
Human cytochrome P450 (CYP) 2A6 metabolizes nicotine to cotinine and is a possible modulator of nicotine addiction. Quantitative and qualitative differences in nicotine addiction have been observed...