Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients (2001)
Maebashi, Kazunori, Niimi, Masakazu, Kudoh, Michinari, Fischer, Frank J., Makimura, Koichi, Niimi, Kyoko, ...
Four Candida albicans isolates, TIMM 3163, TIMM 3164, TIMM 3165 and TIMM 3166, with reduced fluconazole susceptibility were obtained from three AIDS patients in Japan, and the mechanisms of their...
Hosseini-Mazinani, S. M., Koshikawa, Naoki, Sugimoto, Kazunori, Aoki, Yuhko, Arisawa, Mikio
A DNA fragment of 2.1 kb was specifically amplified by PCR with primers based on the amino acid sequences obtained from the N-terminal region and the cyanogen bromide-derived peptide of the sulfite...
Uritani, Masahiro, Nakano, Kyoko, Aoki, Yuhko, Shimada, Hisao, Arisawa, Mikio
EF-3 is a translational elongation factor specific to yeasts and fungi. Its carboxy-terminal region contains three lysine-clusters and is very basic. The region has been reported to be responsible...
ARISAWA, Mikio, MARUYAMA, Hiromi B.
During growth under phosphate-deficient conditions, Escherichia coli K12:W3110 cells acquired an apparent resistance to hypotonic lysis accompanied by a markedly reduced release of perienzymes into...
Yamazaki, Toshikazu, Kume, Hikaru, Murase, Setsuko, Yamashita, Eriko, Arisawa, Mikio
The data on visceral mycoses that had been reported in the Annual of the Pathological Autopsy Cases in Japan from 1969 to 1994 by the Japanese Society of Pathology were analyzed epidemiologically....
Depletion of the Squalene Synthase (ERG9) Gene Does Not Impair Growth of Candida glabrata in Mice
Nakayama, Hironobu, Izuta, Miho, Nakayama, Noboru, Arisawa, Mikio, Aoki, Yuko
Squalene synthase (farnesyl-diphosphate farnesyltransferase, EC 2.5.1.21) is the first committed enzyme of the sterol biosynthesis pathway. Inhibitors of this enzyme have been intensively studied as...
In Vitro and In Vivo Effects of 14α-Demethylase (ERG11) Depletion in Candida glabrata
Nakayama, Hironobu, Nakayama, Noboru, Arisawa, Mikio, Aoki, Yuko
Sterol 14α-demethylase (ERG11) is the target enzyme of azole antifungals that are widely used for the treatment of fungal infections. Candida glabrata is known to be less susceptible to fluconazole...
Hamada, Kenji, Terashima, Hiromichi, Arisawa, Mikio, Yabuki, Nami, Kitada, Kunio
The final destination of glycosylphosphatidylinositol (GPI)-attached proteins in Saccharomyces cerevisiae is the plasma membrane or the cell wall. Two kinds of signals have been proposed for their...
Nakayama, Hironobu, Mio, Toshiyuki, Nagahashi, Shigehisa, Kokado, Michiko, Arisawa, Mikio, Aoki, Yuko
Conventional tools for elucidating gene function are relatively scarce in Candida albicans, the most prevalent human fungal pathogen. To this end, we developed a convenient system to control gene...
Yamada-Okabe, Toshiko, Mio, Toshiyuki, Ono, Naomi, Kashima, Yuji, Matsui, Mitsuaki, Arisawa, Mikio, ...
The pathogenic fungus Candida albicans harbors three histidine kinase genes called CaSLN1, CaNIK1, and CaHK1. The disruption of any one of these three genes impaired the hyphal formation and...
Unusual Mode of Inhibition of Citrobacter freundii β-Lactamases by Ceftriaxone
Arisawa, Mikio, Ohshima, Junko, Maruyama, Hiromi B.
Several Citrobacter freundii β-lactamases, discernible by their substrate profiles and sensitivities to inhibition by newer cephalosporins, were inhibited by ceftriaxone in an unusual manner....
Slow Joining of Newly Replicated DNA Chains in DNA Polymerase I-Deficient Escherichia coli Mutants*
Okazaki, Reiji, Arisawa, Mikio, Sugino, Akio
In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally...
Yamazaki, Toshikazu, Kume, Hikaru, Murase, Setsuko, Yamashita, Eriko, Arisawa, Mikio
The data on visceral mycoses that had been reported in the Annual of the Pathological Autopsy Cases in Japan from 1969 to 1994 by the Japanese Society of Pathology were analyzed epidemiologically....
Depletion of the Squalene Synthase (ERG9) Gene Does Not Impair Growth of Candida glabrata in Mice
Nakayama, Hironobu, Izuta, Miho, Nakayama, Noboru, Arisawa, Mikio, Aoki, Yuko
Squalene synthase (farnesyl-diphosphate farnesyltransferase, EC 2.5.1.21) is the first committed enzyme of the sterol biosynthesis pathway. Inhibitors of this enzyme have been intensively studied as...
In Vitro and In Vivo Effects of 14α-Demethylase (ERG11) Depletion in Candida glabrata
Nakayama, Hironobu, Nakayama, Noboru, Arisawa, Mikio, Aoki, Yuko
Sterol 14α-demethylase (ERG11) is the target enzyme of azole antifungals that are widely used for the treatment of fungal infections. Candida glabrata is known to be less susceptible to fluconazole...
Hamada, Kenji, Terashima, Hiromichi, Arisawa, Mikio, Yabuki, Nami, Kitada, Kunio
The final destination of glycosylphosphatidylinositol (GPI)-attached proteins in Saccharomyces cerevisiae is the plasma membrane or the cell wall. Two kinds of signals have been proposed for their...
Nakayama, Hironobu, Mio, Toshiyuki, Nagahashi, Shigehisa, Kokado, Michiko, Arisawa, Mikio, Aoki, Yuko
Conventional tools for elucidating gene function are relatively scarce in Candida albicans, the most prevalent human fungal pathogen. To this end, we developed a convenient system to control gene...
Yamada-Okabe, Toshiko, Mio, Toshiyuki, Ono, Naomi, Kashima, Yuji, Matsui, Mitsuaki, Arisawa, Mikio, ...
The pathogenic fungus Candida albicans harbors three histidine kinase genes called CaSLN1, CaNIK1, and CaHK1. The disruption of any one of these three genes impaired the hyphal formation and...
Unusual Mode of Inhibition of Citrobacter freundii β-Lactamases by Ceftriaxone
Arisawa, Mikio, Ohshima, Junko, Maruyama, Hiromi B.
Several Citrobacter freundii β-lactamases, discernible by their substrate profiles and sensitivities to inhibition by newer cephalosporins, were inhibited by ceftriaxone in an unusual manner....
Slow Joining of Newly Replicated DNA Chains in DNA Polymerase I-Deficient Escherichia coli Mutants*
Okazaki, Reiji, Arisawa, Mikio, Sugino, Akio
In Escherichia coli mutants deficient in DNA polymerase I, newly replicated short DNA is joined at about 10% of the rate in the wild-type strains. It is postulated that DNA polymerase I normally...