This research was designed to ascertain the effect of having a roommate(s) from America in relation to the grade point averages (GPA) and the degrees of cultural assimilation of students from China....
This research was designed to ascertain the effect of having a roommate(s) from America in relation to the grade point averages (GPA) and the degrees of cultural assimilation of students from China....
ATOM: a powerful gene-based association test by combining optimally weighted markers (2009)
Li, Mingyao, Wang, Kai, Grant, Struan F. A., Hakonarson, Hakon, Li, Chun
Background: Large-scale candidate-gene and genome-wide association studies genotype multiple SNPs within or surrounding a gene, including both tag and functional SNPs. The immense amount of data...
Keating, Brendan J, Tischfield, Sam, Murray, Sarah S, Bhangale, Tushar, Price, Thomas S, Glessner, Joseph T, ...
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide...
Genetic and population analysis GWAsimulator: A rapid whole genome simulation program (2008)
Summary: GWAsimulator implements a rapid moving-window algorithm to simulate genotype data for case-control or population samples from genomic SNP chips. For case-control data, the program generates...
Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms (2008)
Diskin, Sharon J., Li, Mingyao, Hou, Cuiping, Yang, Shuzhang, Glessner, Joseph, Hakonarson, Hakon, ...
Whole-genome microarrays with large-insert clones designed to determine DNA copy number often show variation in hybridization intensity that is related to the genomic position of the clones. We found...
GWAsimulator: a rapid whole-genome simulation program (2008)
Summary: GWAsimulator implements a rapid moving-window algorithm to simulate genotype data for case-control or population samples from genomic SNP chips. For case-control data, the program generates...
Modeling genetic inheritance of copy number variations (2008)
Wang, Kai, Chen, Zhen, Tadesse, Mahlet G., Glessner, Joseph, Grant, Struan F. A., Hakonarson, Hakon, ...
Copy number variations (CNVs) are being used as genetic markers or functional candidates in gene-mapping studies. However, unlike single nucleotide polymorphism or microsatellite genotyping...
Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population (2007)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease with a moderately strong genetic component. Previous linkage and candidate gene studies have identified several regions that predispose to...
Wang, Kai, Li, Mingyao, Hadley, Dexter, Liu, Rui, Glessner, Joseph, Grant, Struan F.A., ...
Comprehensive identification and cataloging of copy number variations (CNVs) is required to provide a complete view of human genetic variation. The resolution of CNV detection in previous...
Statistical methods in gene mapping of complex diseases. (2005)
Dissertation (Ph.D.)--University of Michigan.
Zareparsi, Sepideh, Buraczynska, Monika, Branham, Kari E.H., Shah, Sapna, Eng, Donna, Li, Mingyao, ...
Age-related macular degeneration (AMD) is a genetically heterogeneous disease that leads to progressive and irreversible vision loss among the elderly. Inflammation, oxidative damage, cholesterol...
Li, Mingyao, Boehnke, Michael, Abecasis, Gonçalo R.
Linkage mapping of complex diseases is often followed by association studies between phenotypes and marker genotypes through use of case-control or family-based designs. Given fixed genotyping...
Quantitative Trait Linkage Analysis Using Gaussian Copulas
Li, Mingyao, Boehnke, Michael, Abecasis, Gonçalo R., Song, Peter X.-K.
Mapping and identifying variants that influence quantitative traits is an important problem for genetic studies. Traditional QTL mapping relies on a variance-components (VC) approach with the key...
Joint Modeling of Linkage and Association: Identifying SNPs Responsible for a Linkage Signal
Li, Mingyao, Boehnke, Michael, Abecasis, Gonçalo R.
Once genetic linkage has been identified for a complex disease, the next step is often association analysis, in which single-nucleotide polymorphisms (SNPs) within the linkage region are genotyped...
Zareparsi, Sepideh, Branham, Kari E. H., Li, Mingyao, Shah, Sapna, Klein, Robert J., Ott, Jurg, ...
Using a large sample of cases and controls from a single center, we show that a T→C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with susceptibility to...
Li, Mingyao, Boehnke, Michael, Abecasis, Gonçalo R.
Linkage mapping of complex diseases is often followed by association studies between phenotypes and marker genotypes through use of case-control or family-based designs. Given fixed genotyping...
Quantitative Trait Linkage Analysis Using Gaussian Copulas
Li, Mingyao, Boehnke, Michael, Abecasis, Gonçalo R., Song, Peter X.-K.
Mapping and identifying variants that influence quantitative traits is an important problem for genetic studies. Traditional QTL mapping relies on a variance-components (VC) approach with the key...
Grant, Struan F. A., Li, Mingyao, Bradfield, Jonathan P., Kim, Cecilia E., Annaiah, Kiran, Santa, Erin, ...
Recently an association was demonstrated between the single nucleotide polymorphism (SNP), rs9939609, within the FTO locus and obesity as a consequence of a genome wide association (GWA) study of...
Wang, Kai, Li, Mingyao, Hadley, Dexter, Liu, Rui, Glessner, Joseph, Grant, Struan F.A., ...
Comprehensive identification and cataloging of copy number variations (CNVs) is required to provide a complete view of human genetic variation. The resolution of CNV detection in previous...
Genome-wide linkage and association analysis of rheumatoid arthritis in a Canadian population
Rheumatoid arthritis (RA) is an autoimmune disease with a moderately strong genetic component. Previous linkage and candidate gene studies have identified several regions that predispose to RA,...
Ewens, Warren J., Li, Mingyao, Spielman, Richard S.
Quantitative trait transmission/disequilibrium tests (quantitative TDTs) are commonly used in family-based genetic association studies of quantitative traits. Despite the availability of various...
Keating, Brendan J., Tischfield, Sam, Murray, Sarah S., Bhangale, Tushar, Price, Thomas S., Glessner, Joseph T., ...
A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide...
Adjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms
Diskin, Sharon J., Li, Mingyao, Hou, Cuiping, Yang, Shuzhang, Glessner, Joseph, Hakonarson, Hakon, ...
Whole-genome microarrays with large-insert clones designed to determine DNA copy number often show variation in hybridization intensity that is related to the genomic position of the clones. We found...
Modeling genetic inheritance of copy number variations
Wang, Kai, Chen, Zhen, Tadesse, Mahlet G., Glessner, Joseph, Grant, Struan F. A., Hakonarson, Hakon, ...
Copy number variations (CNVs) are being used as genetic markers or functional candidates in gene-mapping studies. However, unlike single nucleotide polymorphism or microsatellite genotyping...
Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans
Edmondson, Andrew C., Brown, Robert J., Kathiresan, Sekar, Cupples, L. Adrienne, Demissie, Serkalem, Manning, Alisa Knodle, ...
Elevated plasma concentrations of HDL cholesterol (HDL-C) are associated with protection from atherosclerotic cardiovascular disease. Animal models indicate that decreased expression of endothelial...
Bucan, Maja, Abrahams, Brett S., Wang, Kai, Glessner, Joseph T., Herman, Edward I., Sonnenblick, Lisa I., ...
The genetics underlying the autism spectrum disorders (ASDs) is complex and remains poorly understood. Previous work has demonstrated an important role for structural variation in a subset of cases,...
Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease
Wang, Kai, Zhang, Haitao, Kugathasan, Subra, Annese, Vito, Bradfield, Jonathan P., Russell, Richard K., ...
Previous genome-wide association (GWA) studies typically focus on single-locus analysis, which may not have the power to detect the majority of genuinely associated loci. Here, we applied pathway...