Rapid serological detection of autoantibodies associated with Sjögren's syndrome (2009)
Burbelo, Peter D, Ching, Kathryn H, Issa, Alexandra T, Loftus, Caroline M, Li, Yi, Satoh, Minoru, ...
Abstract Background Sjögren's syndrome (SjS) is a relatively common autoimmune disease characterized by oral and ocular dryness. There is an increasing need for simple, sensitive and rapid...
Palafox Sánchez, Claudia, Satoh, Minoru, Chan, Edward KL, Carcamo, Wendy C, Muñoz Valle, José, Orozco Barocio, Gerardo, ...
Abstract Introduction Systemic lupus erythematosus is characterized by production of autoantibodies to RNA or DNA–protein complexes such as small nuclear ribonucleoproteins (snRNPs). A role of...
Li, Yi, Lee, Pui Y, Sobel, Eric S, Narain, Sonali, Satoh, Minoru, Segal, Mark S, ...
Abstract Introduction The high-affinity receptor for IgG Fcγ/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune...
Pauley, Kaleb M, Satoh, Minoru, Chan, Annie L, Bubb, Michael R, Reeves, Westley H, Chan, Edward KL
Abstract Introduction MicroRNAs are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their targeted mRNAs. It is known that...
Satoh, Minoru, Fujimoto, Sohachi, Arakawa, Sayaka, Yada, Toyotaka, Namikoshi, Tamehachi, Haruna, Yoshisuke, ...
Background Recent studies showed that angiotensin II type 1 receptor blocker (ARB) slows progression of chronic renal disease in patients with type 2 diabetes, regardless of changes in blood...
Yamasaki, Yoshioki, Narain, Sonali, Hernandez, Liza, Barker, Tolga, Ikeda, Keigo, Segal, Mark S, ...
Abstract Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa, is a single-stranded-DNA-binding factor involved in DNA replication, repair, and...
Autoimmune targeting of key components of RNA interference (2006)
Jakymiw, Andrew, Ikeda, Keigo, Fritzler, Marvin J, Reeves, Westley H, Satoh, Minoru, Chan, Edward KL
Abstract RNA interference (RNAi) is an evolutionarily conserved mechanism that is involved in the post-transcriptional silencing of genes. This process elicits the degradation or translational...
Distinctive Patterns of Autoimmune Response Induced by Different Types of Mineral Oil (2004)
Kuroda, Yoshiki, Akaogi, Jun, Nacionales, Dina C., Wasdo, Scott C., Szabo, Nancy J., Reeves, Westley H., ...
Although mineral oils are generally considered nontoxic and have a long history of use in humans, the mineral oil Bayol F (incomplete Freund's adjuvant, IFA) and certain mineral oil components...
Distinctive Patterns of Autoimmune Response Induced by Different Types of Mineral Oil (2004)
Kuroda, Yoshiki, Akaogi, Jun, Nacionales, Dina C., Wasdo, Scott C., Szabo, Nancy J., Reeves, Westley H., ...
Although mineral oils are generally considered non-toxic and have a long history of use in humans, the mineral oil Bayol F (incomplete Freund's adjuvant, IFA) and certain mineral oil components...
Satoh, Minoru, Mizutani, Akiei, Behney, Krista M., Kuroda, Yoshiki, Akaogi, Jun, Yoshida, Hideo, ...
Murine lupus can occur spontaneously or be induced by hydrocarbons, such as pristane. Spontaneous disease in MRL and NZB/W F1 mice is suppressed by the xid (X‐linked immunodeficiency) mutation,...
Usui, Hitomi, Shikata, Kenichi, Matsuda, Mitsuhiro, Okada, Shinichi, Ogawa, Daisuke, Yamashita, Tetsuji, ...
Background. An inflammatory process may be one of the critical factors that contribute to the development of diabetic nephropathy (DN). We reported previously that intercellular adhesion...
Mukai, Yasushi, Rikitake, Yoshiyuki, Shiojima, Ichiro, Wolfrum, Sebastian, Satoh, Minoru, Takeshita, Kyosuke, ...
To determine whether endothelial Akt could affect vascular lesion formation, mutant mice with a constitutively active Akt transgene, which could be inducibly targeted to the vascular endothelium...
Requirement of Rac1 in the development of cardiac hypertrophy
Satoh, Minoru, Ogita, Hisakazu, Takeshita, Kyosuke, Mukai, Yasushi, Kwiatkowski, David J., Liao, James K.
The development of cardiac hypertrophy is mediated, in part, by increase in NADPH oxidase activity and myocardial oxidative stress. The Rho GTPase, Rac, regulates NADPH oxidase activity through...
Mukai, Yasushi, Rikitake, Yoshiyuki, Shiojima, Ichiro, Wolfrum, Sebastian, Satoh, Minoru, Takeshita, Kyosuke, ...
To determine whether endothelial Akt could affect vascular lesion formation, mutant mice with a constitutively active Akt transgene, which could be inducibly targeted to the vascular endothelium...
Requirement of Rac1 in the development of cardiac hypertrophy
Satoh, Minoru, Ogita, Hisakazu, Takeshita, Kyosuke, Mukai, Yasushi, Kwiatkowski, David J., Liao, James K.
The development of cardiac hypertrophy is mediated, in part, by increase in NADPH oxidase activity and myocardial oxidative stress. The Rho GTPase, Rac, regulates NADPH oxidase activity through...
Yamasaki, Yoshioki, Narain, Sonali, Hernandez, Liza, Barker, Tolga, Ikeda, Keigo, Segal, Mark S, ...
Replication protein A (RPA), a heterotrimer with subunits of molecular masses 70, 32, and 14 kDa, is a single-stranded-DNA-binding factor involved in DNA replication, repair, and recombination. There...
Autoimmune targeting of key components of RNA interference
Jakymiw, Andrew, Ikeda, Keigo, Fritzler, Marvin J, Reeves, Westley H, Satoh, Minoru, Chan, Edward KL
RNA interference (RNAi) is an evolutionarily conserved mechanism that is involved in the post-transcriptional silencing of genes. This process elicits the degradation or translational inhibition of...
Nacionales, Dina C., Kelly, Kindra M., Lee, Pui Y., Zhuang, Haoyang, Li, Yi, Weinstein, Jason S., ...
Lymphoid neogenesis is associated with antibody-mediated autoimmune diseases such as Sjogren’s syndrome and rheumatoid arthritis. Although systemic lupus erythematosus is the prototypical...
Amelioration of progressive renal injury by genetic manipulation of Klotho gene
Haruna, Yoshisuke, Kashihara, Naoki, Satoh, Minoru, Tomita, Naruya, Namikoshi, Tamehachi, Sasaki, Tamaki, ...
Klotho, an antiaging gene with restricted organ distribution, is mainly expressed in the kidney tubules; the mutant mice have shortened life span, arteriosclerosis, anemia, and osteoporesis, features...
Haruna, Yoshisuke, Morita, Yoshitaka, Yada, Toyotaka, Satoh, Minoru, Fox, David A., Kashihara, Naoki
Objective To investigate the effect of statins on vascular dysfunction in rat adjuvant-induced arthritis (AIA). Methods Fluvastatin (5 mg/kg/day) was administered orally to rats with AIA, for 21 days...
Small Interfering RNA-mediated Silencing Induces Target-dependent Assembly of GW/P Bodies
Lian, Shangli, Fritzler, Marvin J., Katz, Joseph, Hamazaki, Takashi, Terada, Naohiro, Satoh, Minoru, ...
Gene silencing using small interfering RNA (siRNA) is a valuable laboratory tool and a promising approach to therapeutics for a variety of human diseases. Recently, RNA interference (RNAi) has been...
Richards, Hanno B., Satoh, Minoru, Shaw, Melody, Libert, Claude, Poli, Valeria, Reeves, Westley H.
Pristane induces a lupus-like syndrome in nonautoimmune mice characterized by the development of glomerulonephritis and lupus-associated autoantibodies. This is accompanied by overproduction of...
Satoh, Minoru, Fujimoto, Sohachi, Arakawa, Sayaka, Yada, Toyotaka, Namikoshi, Tamehachi, Haruna, Yoshisuke, ...
Background Recent studies showed that angiotensin II type 1 receptor blocker (ARB) slows progression of chronic renal disease in patients with type 2 diabetes, regardless of changes in blood...
Palafox Sánchez, Claudia Azucena, Satoh, Minoru, Chan, Edward KL, Carcamo, Wendy C, Muñoz Valle, José Francisco, Orozco Barocio, Gerardo, ...
TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus
Lee, Pui Y., Kumagai, Yutaro, Li, Yi, Takeuchi, Osamu, Yoshida, Hideo, Weinstein, Jason, ...
Increased type I interferon (IFN-I) production and IFN-stimulated gene (ISG) expression are linked to the pathogenesis of systemic lupus erythematosus (SLE). Although the mechanisms responsible for...