Uhlirova, Mirka, Foy, Brian D., Beaty, Barry J., Olson, Ken E., Riddiford, Lynn M., Jindra, Marek
The transcription factor Broad-Complex (BR-C) is required for differentiation of adult structures as well as for the programmed death of obsolete larval organs during metamorphosis of the fruit fly...
Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila
Jindra, Marek, Gaziova, Ivana, Uhlirova, Mirka, Okabe, Masataka, Hiromi, Yasushi, Hirose, Susumu
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by...
Uhlirova, Mirka, Jasper, Heinrich, Bohmann, Dirk
The role of c-Jun N-terminal kinase (JNK) signaling in cancer is enigmatic, and both tumor-promoting and tumor-suppressing functions have been ascribed to JNK pathway components. We have used the...
Uhlirova, Mirka, Foy, Brian D., Beaty, Barry J., Olson, Ken E., Riddiford, Lynn M., Jindra, Marek
The transcription factor Broad-Complex (BR-C) is required for differentiation of adult structures as well as for the programmed death of obsolete larval organs during metamorphosis of the fruit fly...
Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila
Jindra, Marek, Gaziova, Ivana, Uhlirova, Mirka, Okabe, Masataka, Hiromi, Yasushi, Hirose, Susumu
Basic leucine zipper proteins Jun and Fos form the dimeric transcription factor AP-1, essential for cell differentiation and immune and antioxidant defenses. AP-1 activity is controlled, in part, by...
Uhlirova, Mirka, Jasper, Heinrich, Bohmann, Dirk
The role of c-Jun N-terminal kinase (JNK) signaling in cancer is enigmatic, and both tumor-promoting and tumor-suppressing functions have been ascribed to JNK pathway components. We have used the...
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila
Uhlirova, Mirka, Bohmann, Dirk
Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to induce malignant tumors. Such mutant tissue overproliferates, resists...