Identifying novel constrained elements by exploiting biased substitution patterns (2009)
Garber, Manuel, Guttman, Mitchell, Clamp, Michele, Zody, Michael C., Friedman, Nir, Xie, Xiaohui
Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved...
Mitchell Guttman, Carolyn Mies, Katarzyna Dudycz-Sulicz, Sharon J. Diskin, Don A. Baldwin, Christian J. Stoeckert Jr., ...
Genomic aberrations recurrent in a particular cancer type can be important prognostic markers for tumor progression. Typically in early tumorigenesis, cells incur a breakdown of the DNA replication...
Guttman, Mitchell, Mies, Carolyn, Dudycz-Sulicz, Katarzyna, Diskin, Sharon J, Baldwin, Don A, Stoeckert, Christian J, ...
Genomic aberrations recurrent in a particular cancer type can be important prognostic markers for tumor progression. Typically in early tumorigenesis, cells incur a breakdown of the DNA replication...
Identifying novel constrained elements by exploiting biased substitution patterns
Garber, Manuel, Guttman, Mitchell, Clamp, Michele, Zody, Michael C., Friedman, Nir, Xie, Xiaohui
Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved...
Khalil, Ahmad M., Guttman, Mitchell, Huarte, Maite, Garber, Manuel, Raj, Arjun, Rivea Morales, Dianali, ...
We recently showed that the mammalian genome encodes >1,000 large intergenic noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene expression patterns have...