Mithun Vinod Shah

Network model of survival signaling in large granular lymphocyte leukemia

Zhang, Ranran, Shah, Mithun Vinod, Yang, Jun, Nyland, Susan B., Liu, Xin, Yun, Jong K., ...

T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T lymphocytes (CTL). To systematically understand signaling components that...

Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes

Shah, Mithun Vinod, Zhang, Ranran, Irby, Rosalyn, Kothapalli, Ravi, Liu, Xin, Arrington, Ty, ...

T-cell large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of CD3+CD8+ cells. Leukemic LGLs correspond to terminally differentiated effector-memory cytotoxic T lymphocytes...