Monika Löffler

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain (2004)

Hansen, Majbritt, Le Nours, Jérôme, Johansson, Eva, Antal, Torben, Ullrich, Alexandra, Löffler, Monika, ...

The flavin enzyme dihydroorotate dehydrogenase (DHOD; EC 1.3.99.11) catalyzes the oxidation of dihydroorotate to orotate, the fourth step in the de novo pyrimidine biosynthesis of UMP. The enzyme is...

Functional Expression of Human Dihydroorotate Dehydrogenase (DHODH) in pyr4 Mutants of Ustilago maydis Allows Target Validation of DHODH Inhibitors In Vivo▿

Zameitat, Elke, Freymark, Gerald, Dietz, Cornelia D., Löffler, Monika, Bölker, Michael

Dihydroorotate dehydrogenase (DHODH; EC 1.3.99.11) is a central enzyme of pyrimidine biosynthesis and catalyzes the oxidation of dihydroorotate to orotate. DHODH is an important target for...

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain

Hansen, Majbritt, Le Nours, Jérôme, Johansson, Eva, Antal, Torben, Ullrich, Alexandra, Löffler, Monika, ...

The flavin enzyme dihydroorotate dehydrogenase (DHOD; EC 1.3.99.11) catalyzes the oxidation of dihydroorotate to orotate, the fourth step in the de novo pyrimidine biosynthesis of UMP. The enzyme is...

KATP channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart

Hanley, Peter J, Mickel, Markus, Löffler, Monika, Brandt, Ulrich, Daut, Jürgen

Diazoxide and 5-hydroxydecanoate (5-HD; C10:0) are reputed to target specifically mitochondrial ATP-sensitive K+ (KATP) channels. Here we describe KATP channel-independent targets of diazoxide and...