Montserrat Aguadé

Polimorfisme nucleotídic i canvis adaptatius recents (2009)

Montserrat Aguadé

En observar els individus d'una espècie es detecten característiques que els fan estar especialment adaptats al medi biòtic i abiòtic en què es troben. La selecció natural és la força motriu...

Nucleotide and Copy-Number Polymorphism at the Odorant Receptor Genes Or22a and Or22b in Drosophila melanogaster (2009)

Aguadé, Montserrat

In Drosophila, odorant receptors are encoded by an old and moderately sized multigene family. Or22a and Or22b are two tandemly arranged genes of this family that have proved to be the result of a...

Positive Selection Has Driven the Evolution of the Drosophila Insulin-Like Receptor (InR) at Different Timescales (2009)

Guirao-Rico, Sara, Aguadé, Montserrat

The highly conserved insulin-signaling pathway influences very diverse processes including intermediary metabolism, reproduction, aging, and growth. The first pathway component is the insulin...

Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes (2009)

Alvarez-Ponce, David, Aguadé, Montserrat, Rozas, Julio

Biological function is based on complex networks consisting of large numbers of interacting molecules. The evolutionary properties of molecular networks and, in particular, the impact of network...

Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster (2007)

Orengo, Dorcas J., Aguadé, Montserrat

Nucleotide variation in populations originating from the recent range expansion of a species should reflect their adaptation to new habitats as well as their demographic history. A survey of...

Genome Scans of Variation and Adaptive Change: Extended Analysis of a Candidate Locus Close to the phantom Gene Region in Drosophila melanogaster (2007)

Orengo, Dorcas J., Aguadé, Montserrat

Nucleotide variation in populations originating from the recent range expansion of a species should reflect their adaptation to new habitats as well as their demographic history. A survey of...

Positive Selection Versus Demography: Evolutionary Inferences Based on an Unusual Haplotype Structure in Drosophila simulans (2006)

Quesada, Humberto, Ramos-Onsins, Sebastián E., Rozas, Julio, Aguadé, Montserrat

Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of D. simulans...

Positive Selection Versus Demography: Evolutionary Inferences Based on an Unusual Haplotype Structure in Drosophila simulans (2006)

Quesada, Humberto, Ramos-Onsins, Sebastián E., Rozas, Julio, Aguadé, Montserrat

Coalescent simulations were used to investigate the possible role of population subdivision and history in shaping nucleotide variation in a recombining 88-kb genomic fragment of Drosophila simulans...

Comparative Molecular Population Genetics of the Xdh Locus in the Cactophilic Sibling Species Drosophila buzzatii and D. koepferae (2004)

Piccinali, Romina, Aguadé, Montserrat, Hasson, Esteban

The Xdh (rosy) gene is one of the best studied in the Drosophila genus from an evolutionary viewpoint. Here we analyze nucleotide variation in a 1875-bp fragment of the second exon of Xdh in...

Excess of Nonsynonymous Polymorphism at Acph-1 in Different Gene Arrangements of Drosophila subobscura (2003)

Navarro-Sabaté, Àurea, Aguadé, Montserrat, Segarra, Carmen

Nucleotide variation in the Acph-1 gene region was analyzed in a natural population of Drosophila subobscura from Bizerte (Tunisia). The lines studied differed in their gene arrangement for segment I...

Nucleotide Polymorphism in the RpII215 Gene Region of the Insular Species Drosophila guanche: Reduced Efficacy of Weak Selection on Synonymous Variation (2003)

Pérez, José A., Munté, Agustí, Rozas, Julio, Segarra, Carmen, Aguadé, Montserrat

An approximately 6.9-kb region encompassing the RpII215 gene was sequenced for 24 individuals of the island endemic species Drosophila guanche. The comparative analysis of synonymous polymorphism and...

Comparative Molecular Population Genetics of the Xdh Locus in the Cactophilic Sibling Species Drosophila buzzatii and D. koepferae (2003)

Piccinali, Romina, Aguadé, Montserrat, Hasson, Esteban

The Xdh (rosy) gene is one of the best studied in Drosophila from an evolutionary viewpoint. Here we analyze nucleotide variation in an ∼ 1875-bp fragment of the second exon of Xdh in Argentinian...

Excess of Nonsynonymous Polymorphism at Acph-1 in Different Gene Arrangements of Drosophila subobscura (2003)

Navarro-Sabaté, Àurea, Aguadé, Montserrat, Segarra, Carmen

Nucleotide variation in the Acph-1 gene region was analyzed in a natural population of Drosophila subobscura from Bizerte (Tunisia). The lines studied differed in their gene arrangement for segment I...

Nucleotide Polymorphism in the RpII215 Gene Region of the Insular Species Drosophila guanche: Reduced Efficacy of Weak Selection on Synonymous Variation (2003)

Pérez, José A., Munté, Agustí, Rozas, Julio, Segarra, Carmen, Aguadé, Montserrat

An approximately 6.9-kb region encompassing the RpII215 gene was sequenced for 24 individuals of the island endemic species Drosophila guanche. The comparative analysis of synonymous polymorphism and...

Excess of Nonsynonymous Polymorphism at Acph-1 in Different Gene Arrangements of Drosophila subobscura (2003)

Navarro-Sabaté, Àurea, Aguadé, Montserrat, Segarra, Carmen

Nucleotide variation in the Acph-1 gene region was analyzed in a natural population of Drosophila subobscura from Bizerte (Tunisia). The lines studied differed in their gene arrangement for segment I...

Nucleotide Polymorphism in the RpII215 Gene Region of the Insular Species Drosophila guanche: Reduced Efficacy of Weak Selection on Synonymous Variation (2003)

Pérez, José A., Munté, Agustí, Rozas, Julio, Segarra, Carmen, Aguadé, Montserrat

An approximately 6.9-kb region encompassing the RpII215 gene was sequenced for 24 individuals of the island endemic species Drosophila guanche. The comparative analysis of synonymous polymorphism and...

Comparative Molecular Population Genetics of the Xdh Locus in the Cactophilic Sibling Species Drosophila buzzatii and D. koepferae (2003)

Piccinali, Romina, Aguadé, Montserrat, Hasson, Esteban

The Xdh (rosy) gene is one of the best studied in Drosophila from an evolutionary viewpoint. Here we analyze nucleotide variation in an ∼ 1875-bp fragment of the second exon of Xdh in Argentinian...

Nucleotide Sequence Variation at Two Genes of the Phenylpropanoid Pathway, the FAH1 and F3H Genes, in Arabidopsis thaliana (2001)

Aguadé, Montserrat

The FAH1 and F3H genes encode ferulate-5-hydroxylase and flavanone-3-hydroxylase, which are enzymes in the pathways leading to the synthesis of sinapic acid esters and flavonoids, respectively....

Excess Polymorphism at the Adh Locus in DROSOPHILA MELANOGASTER

Kreitman, Martin E., Aguadé, Montserrat

The evolutionary history of a region of DNA encompassing the Adh locus is studied by comparing patterns of variation in Drosophila melanogaster and its sibling species, D. simulans. An unexpectedly...

A Test of Neutral Molecular Evolution Based on Nucleotide Data

Hudson, Richard R., Kreitman, Martin, Aguadé, Montserrat

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of...

Chromosomal Inversion Polymorphism Leads to Extensive Genetic Structure: A Multilocus Survey in Drosophila subobscura

Munté, Agustí, Rozas, Julio, Aguadé, Montserrat, Segarra, Carmen

The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The OST and O3+4 chromosomal arrangements of this species differ by two overlapping inversions that...

DNA Sequence Polymorphism and Divergence at the erect wing and suppressor of sable Loci of Drosophila melanogaster and D. simulans

Braverman, John M., Lazzaro, Brian P., Aguadé, Montserrat, Langley, Charles H.

Several evolutionary models of linked selection (e.g., genetic hitchhiking, background selection, and random environment) predict a reduction in polymorphism relative to divergence in genomic regions...

Large-scale adaptive hitchhiking upon high recombination in Drosophila simulans.

Quesada, Humberto, Ramírez, Ursula E M, Rozas, Julio, Aguadé, Montserrat

Natural selection is expected to leave a characteristic footprint on neighboring nucleotide variation through the effects of genetic linkage. The size of the region affected is proportional to the...

Patterns of nucleotide polymorphism and divergence in the odorant-binding protein genes OS-E and OS-F: analysis in the melanogaster species subgroup of Drosophila.

Sánchez-Gracia, Alejandro, Aguadé, Montserrat, Rozas, Julio

The Olfactory Specific-E and -F genes (OS-E and OS-F) belong to the odorant-binding protein gene family, which includes the general odorant-binding proteins and the pheromone-binding proteins. In...

Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata.

Ramos-Onsins, Sebastián E, Stranger, Barbara E, Mitchell-Olds, Thomas, Aguadé, Montserrat

Nucleotide variation in eight effectively unlinked genes was surveyed in species-wide samples of the closely related outbreeding species Arabidopsis halleri and A. lyrata ssp. petraea and in three of...

Detecting the footprint of positive selection in a european population of Drosophila melanogaster: multilocus pattern of variation and distance to coding regions.

Orengo, Dorcas J, Aguadé, Montserrat

The effects on nucleotide variation of adaptations to temperate habitats and of the possible bottleneck associated with the origin of European populations of Drosophila melanogaster should be...

Excess Polymorphism at the Adh Locus in DROSOPHILA MELANOGASTER

Kreitman, Martin E., Aguadé, Montserrat

The evolutionary history of a region of DNA encompassing the Adh locus is studied by comparing patterns of variation in Drosophila melanogaster and its sibling species, D. simulans. An unexpectedly...

A Test of Neutral Molecular Evolution Based on Nucleotide Data

Hudson, Richard R., Kreitman, Martin, Aguadé, Montserrat

The neutral theory of molecular evolution predicts that regions of the genome that evolve at high rates, as revealed by interspecific DNA sequence comparisons, will also exhibit high levels of...

Chromosomal Inversion Polymorphism Leads to Extensive Genetic Structure: A Multilocus Survey in Drosophila subobscura

Munté, Agustí, Rozas, Julio, Aguadé, Montserrat, Segarra, Carmen

The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The OST and O3+4 chromosomal arrangements of this species differ by two overlapping inversions that...

DNA Sequence Polymorphism and Divergence at the erect wing and suppressor of sable Loci of Drosophila melanogaster and D. simulans

Braverman, John M., Lazzaro, Brian P., Aguadé, Montserrat, Langley, Charles H.

Several evolutionary models of linked selection (e.g., genetic hitchhiking, background selection, and random environment) predict a reduction in polymorphism relative to divergence in genomic regions...

Large-scale adaptive hitchhiking upon high recombination in Drosophila simulans.

Quesada, Humberto, Ramírez, Ursula E M, Rozas, Julio, Aguadé, Montserrat

Natural selection is expected to leave a characteristic footprint on neighboring nucleotide variation through the effects of genetic linkage. The size of the region affected is proportional to the...

Patterns of nucleotide polymorphism and divergence in the odorant-binding protein genes OS-E and OS-F: analysis in the melanogaster species subgroup of Drosophila.

Sánchez-Gracia, Alejandro, Aguadé, Montserrat, Rozas, Julio

The Olfactory Specific-E and -F genes (OS-E and OS-F) belong to the odorant-binding protein gene family, which includes the general odorant-binding proteins and the pheromone-binding proteins. In...

Multilocus analysis of variation and speciation in the closely related species Arabidopsis halleri and A. lyrata.

Ramos-Onsins, Sebastián E, Stranger, Barbara E, Mitchell-Olds, Thomas, Aguadé, Montserrat

Nucleotide variation in eight effectively unlinked genes was surveyed in species-wide samples of the closely related outbreeding species Arabidopsis halleri and A. lyrata ssp. petraea and in three of...

Detecting the footprint of positive selection in a european population of Drosophila melanogaster: multilocus pattern of variation and distance to coding regions.

Orengo, Dorcas J, Aguadé, Montserrat

The effects on nucleotide variation of adaptations to temperate habitats and of the possible bottleneck associated with the origin of European populations of Drosophila melanogaster should be...

The Dynamics of the roo Transposable Element In Mutation-Accumulation Lines and Segregating Populations of Drosophila melanogaster

Papaceit, Montserrat, Ávila, Victoria, Aguadé, Montserrat, García-Dorado, Aurora

We estimated the number of copies for the long terminal repeat (LTR) retrotransposable element roo in a set of long-standing Drosophila melanogaster mutation-accumulation full-sib lines and in two...

Polytene Chromosomal Maps of 11 Drosophila Species: The Order of Genomic Scaffolds Inferred From Genetic and Physical Maps

Schaeffer, Stephen W., Bhutkar, Arjun, McAllister, Bryant F., Matsuda, Muneo, Matzkin, Luciano M., O'Grady, Patrick M., ...

The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the species, in part to aid in the mapping of...

Network-level molecular evolutionary analysis of the insulin/TOR signal transduction pathway across 12 Drosophila genomes

Alvarez-Ponce, David, Aguadé, Montserrat, Rozas, Julio

Biological function is based on complex networks consisting of large numbers of interacting molecules. The evolutionary properties of molecular networks and, in particular, the impact of network...