Role of the Mg2+Ion in the Escherichia coli Ribonuclease HI Reaction (1994)
Uchiyama, Yohtaro, Iwai, Shigenori, Ueno, Yoshio, Ikehara, Morio, Ohtsuka, Eiko
To study the interaction and the role of the metal ion in the reaction catalyzed by Escherichia coli ribonuclease HI (E. coli RNase HI), substrate analogues containing a phosphorothioate linkage or...
Binding of nucleic acids to E.coli RNase HI observed by NMR and CD spectroscopy (1993)
Oda, Yasushi, Iwa, Shigenori, Ohtsuka, Eiko, Ishikawa, Momoyo, Ikehara, Morio, Nakamura, Haruki
To clarify the mechanism by which the RNA portion of a DNA/RNA hybrid is specifically hydrolyzed by ribonuclease H (RNase H), the binding of a DNA/RNA hybrid, a DNA/DNA duplex, or an RNA/RNA duplex...
Crystal Structure of RNase T1(Y45W) Complexed with 3' AMP and Gf1pA (1993)
Gohda, Keigo, Itoh, Takeshi, Hiramatsu, Yasuyuki, Tomita, Ken-ichi, Nishikawa, Satoshi, Uesugi, Sei-ichi, ...
We have previously reported the crystallization of a mutant RNase T1(Y46W) with a synthetic modified trinucleotide ApGflpA [Hakoshima, T. et al. (1990) J. Biochem 108, 695–698]. In the present...
Hori, Naoko, Doi, Tomoko, Karaki, Yoko, Kituchi, Masakazu, Ikehara, Morio, Ohtsuka, Eiko
T4 endonuclease V catalyzes the hydrolysis of the glycosyl bond of a thymine dimer in a DNA duplex and the cleavage of the 3′-phosphate by β-elimination. We have previously identified a catalytic...
Structural models of ribonuclease H domains in reverse transcriptases from retroviruses (1991)
Nakamura, Haruki, Katayanagi, Katsuo, Morikawa, Kosuke, Ikehara, Morio
Tertiary models of ribonuclease H (RNase H) domains in reverse transcriptases (RT8) from Moloney murine leukemia virus (MuLV) and human immunodeficiency virus (HIV-1) were built based upon the X-ray...
NMR studies of a DNA containing 8-hydroxydeoxyguanosine (1991)
Oda, Yasushi, Uesugi, Seichi, Ikehara, Morio, Nishimura, Susumu, Kawase, Yasutoshi, Ishikawa, Hiroyuki, ...
The effects of hydroxylation at the C8 of a deoxyguanosine residue in DNA were studied by NMR analysis of a self-complementary dodecanucleotide, d(C1-G2-C3-oh8G4-A5-A6-T7-T8-C9-G10-C11-G12), which...
NMR studies for identification of dl:dG mismatch base-pairing structure in DNA (1991)
Oda, Yasushi, Uesugi, Seiichi, Ikehara, Morio, Kawase, Yasutoshi, Ohtsuka, Eiko
One- and two-dimensional NMR experiments have been undertaken to Investigate deoxylnosine:deoxyguanosine (dl:dG) base pairing in a seff-complementary dodecadeoxyribonucleotide, d(C1...
Hakoshima, Toshio, Tanaka, Masahiro, Itoh, Takeshi, Tomita, Ken-khi, Amisaki, Takashi, Nishikawa, Satoshi, ...
Hydrophobic effects on binding of ribonuclease Tl to guanine bases of several ribonucleotides have been proved by mutating a hydrophobic residue at the recognition site and by measuring the effect on...
Itoh, Takeshi, Tomita, Ken-ichi, Hakoshima, Toshio, Hiroaki, Hidekazu, Uesugi, Sei-ichi, Nishikawa, Satoshi, ...
The crystal structure of a mutant ribonuclease T1(Y45W) complexed with a specific inhibitor, 2′GMP, has been determined by X-ray diffraction and refined at 1.9 A� resolution to a conventional...
A thermoresistant mutant of ribonuclease T1 having three disulfide bonds (1990)
Nishikawa, Satoshi, Adiwinata, Jeanne, Morioka, Hiroshi, Fujimura, Takao, Tanaka, Toshiki, Uesugi, Seiichi, ...
Molecular-dynamic calculations predict that, if Tyr24 and Asn84 are each replaced by a Cys residue, it should be possible to form a third disulfide bond in ribonuclease T1 (RNase T1) between these...
Hakoshima, Toshio, Oka, Ken-ichi, Toda, Shyoji, Tanaka, Masahiro, Goda, Keigo, Higo, Takashi, ...
Ribonuclease T1 and the mutant enzymes were cocrystallized with several ribonucleotides, including non-hydrolyzable substrate analogs of di- and triribonucleotides, which have a novel guanylate in...
Structure and activity of artificial mutant variants of human growth hormone (1989)
Nishikawa, Satoshi, Nishida, Yoshitaka, Uemura, Haruki, Yamada, Yasuki, Tanaka, Toshiki, Uesugi, Seiichi, ...
Four artificial mutant variants of human growth hormone (hGH) with the following characteristics were prepared in Escherichia coli by in vitro mutagenesis: (i) replacement of Trp86 with Tyr (W86Y...
Hakoshima, Toshio, Toda, Shoji, Sugio, Shigetoshi, Tomita, Ken-ichi, Nishikawa, Satoshi, Morioka, Hiroshi, ...
Recognition by ribonuclease T1 of guanine bases via multidentate hydrogen bonding and stacking interactions appears to be mediated mainly by a short peptide segment formed by one stretch of a...
Miura, Kazunobu, Kamiya, Hiroyuki, Kubota, Sachie, Ikehara, Morio, Nishimura, Susumu, Ohtsuka, Eiko
A gene coding for the novel ras protein, p21x, in which the domains of guanine binding and phosphate binding were exchanged, was constructed and expressed in Escherichia coli. The gene product, p21x,...
Tanaka, Toshiki, Tamatsukuri, Shigeru, Ikehara, Morio
Oligoribonucleotides with chain length of 7, 11, 15, 17, 24 and 34 were synthesized on long chain alkylamine controlled pore glass beads (LCA-CPG) using o-nitrobenzyl protection of 2'-hydroxyis via a...
Tanaka, Toshiki, Sakata, Takeshi, Fujimoto, Kazuko, Ikehara, Morio
Lipophilic protecting groups mTrNHfCH2)n X (mTr: monomethoxy-trityl, X=NH, O, S, n=2, 3, 4, 6) were attachecd to the 51-phosphoryl group of 3′-O-protected thymidine. When the diamine derivatives...
Nishikawa, Satoshi, Yanase, Kohichi, Tokunaga-Doi, Tomoko, Kodama, Kazumi, Gomi, Hideyuki, Uesugi, Seiichi, ...
The gene for insulin-like growth factor I (IGF-I) was constructed from chemically synthesized deoxyoligonucleotides and expressed in Escherichia coli, under the control of a trp promoter, as a set of...
Tanaka, Toshiki, Tamatsukuri, Shigeru, Ikehara, Morio
The hepta and undecaribonucleotide were synthesized on a controlled pore glass beads using o-nitrobenzyl protection of 2′-hydroxyls via a phosphite approach. By using 5-p-nitrophenyltetrazole for...
Doi, Takefumi, Yamane, Akio, Matsugi, Jitsuhiro, Ohtsuka, Eiko, Ikehara, Morio
Insertion of the four major nucleotides at the 5′-side of the anticodon triplet of E. coli tRNAMet was performed by joining of the half molecules obtained b limited digestion with RNase A and the...
LEE, Sang Jong, AKUTSU, Hideo, KYOGOKU, Yoshimasa, KITANO, Katsuhiko, TOZUKA, Zenzaburo, OHTA, Atsunori, ...
The imino proton resonances of λ OR3 17mer in water were observed at 500 Mhz with the time-shared Redfield pulse train. All of the 17 imino proton resonances could be assigned specifically to...
KUWANO, Ryozo, ARAKI, Kazuaki, USUI, Hiroshi, FUKUI, Toshikazu, OHTSUKA, Eiko, IKEHARA, Morio, ...
A mixture of 14-mer oligodeoxynucleotides was used for the screening of a cDNA clone coding for a cholecystokinin (CCK) precursor from a cDNA library for rat brain microsomal poly(A)RNA. The longest...
Uesugi, Seiichi, Ohkubo, Mitsuru, Ohtsuka, Eiko, Ikehara, Morio, Kobayashi, Yuji, Kyogoku, Yoshimasa
The poly [r(C-G)]duplex shows an unusually large negative CD band in the long wavelength region. in order to elucidate this phenomenon, r(C-G-C-G) and r(C-G-C-G-C-G) were synthesized by a...
Uesugi, Seiichi, Shida, Toshio, Ikehara, Morio, Kobayashi, Yuji, Kyogoku, Yoshimasa
To elucidate the mechanism of DNA strand scission by bleomycin, a d(C-G C-G-C-G) duplex was treated with the bleomycin-iron ion complex in the presence of H2 O2 and degradation products (1, 2,...
Kuwano, Ryozo, Usui, Hiroshi, Maeda, Toshinaga, Fukui, Toshikazu, Yamanari, Nobuko, Ohtsuka, Eiko, ...
The complete nucleotide sequence of mRNA for β-subunit of rat brain S-100 protein was determined from recombinant cDNA clones. The sequence was composed of 1488 bp which Included the 276 bp of the...
Nishimura, Yoshifumi, Tsuboi, Masamichi, Nakano, Toru, Higuchi, Shigesada, Sato, Tomohiro, Shida, Toshio, ...
Observations of Raman spectra of various nucleic acids indicate that the guanine ring breathing frequency is sensitive to the internal rotation angle around the glycosidic bond and to the...
Ohtsuka, Eiko, Doi, Takefumi, Fukumoto, Ryoichi, Matsugi, Jitsuhiro, Ikehara, Morio
E. coli tRNAfMet was hydrolyzed with RNase A using a limited amount of the enzyme to give two half molecules lacking the anticodon trimer and 3′-terminal dimer. Chemically synthesized trimers CUAp...
Ohtsuka, Eiko, Taniyama, Yoshio, Marumoto, Ryuji, Sato, Hiroko, Hirosaki, Haruhisa, Ikehara, Morio
A phosphorylating reagent o-chlorophenyl phosphoro-p-anisi-dochloridate was synthesized to phosphorylate the 3'-hydroxyl group of N, 5'-protected deoxynucleosides. These nucleotides served as...
E. coli initiator tRNA analogs with different nucleotides in the discriminator base position (1982)
Uemura, Haruki, Imai, Mayumi, Ohtsuka, Eiko, Ikehara, Morio, Söll, Dieter
The effect of base changes at the fourth position from the 3′-terminus of Esoheriohia coli initiator tRNA Met has been studied to test the ′discriminator hypothesis′ which proposed that the...
FUKUI, Toshikazu, ISHIHAMA, Akira, OHTSUKA, Eiko, IKEHARA, Morio, FUKUDA, Ryuji
The influence of oligodeoxynucleotide chain length on the priming activity of the reverse transcription was investigated in poly(A)-dependent poly(dT), poly(C)-dependent poly(dG) and influenza virus...
The crystal and molecular structure of 2':-deoxy-2':-fluoroinosine monohydrate (1981)
Hakoshima, Toshio, Omori, Hisako, Tomita, Ken-ichi, Miki, Hiroko, Ikehara, Morio
The structure of the hydrate of 2′-deoxy-2′-fluoroinosine has been determined by single-crystal x-ray diffraction. The nucleoslde crystallises inspace group P212121, with unit cell dimensions, a...
WATANABE, Takahide, INOUE, Akio, TONOMURA, Yuji, UESUGI, Seiichi, IKEHARA, Morio
A fluorescent ATP analog, 2′-(5-dimethylaminonaphthalene-1-sulfonyl)amino-2′-deoxy ATP (DNS-ATP), was synthesized. In water, the wavelengths of maximum excitation were 260 and 340 nm, and that of...
Characterization of nascent DNA fragments produced by excision of uracil residues in DNA (1981)
Machida, Yasunori, Okazaki, Tuneko, Miyake, Tetsuo, Ohtsuka, Eiko, Ikehara, Morio
Nascent short DNA chains could result from repair of incorporated uracil residues or be intermediates in discontinuous replication. We have characterized short DNA chains having...
KAWAKAMI, Kiyoshi, ISHIHAMA, Akira, OHTSUKA, Eiko, TANAKA, Toshiki, TAKASHIMA, Hideaki, IKEHARA, Morio
The virion-associated RNA-dependent RNA polymerase of influenza virus PR8 was activated by treatment with specific non-ionic detergents, and was remarkably stimulated by exogenously added...
Ohtsuka, Eiko, Doi, Takefumi, Uemura, Haruki, Taniyama, Yoshio, Ikehara, Morio
A tetradecanucleotide U-A-G-C (U-C-G)2G-G-C-Up corresponding to bases 21–34 of a nascent sequence of formylmethionyl tRNA of E. coli has been synthesized by the joining of two combinations of...
ISHIHAMA, Akira, ENAMI, Masayoshi, NISHIJIMA, Yoshikazu, FUKUI, Toshikazu, OHTSUKA, Eiko, IKEHARA, Morio
The effects of 2′-substitutions of ATP on the substrate and inhibitor properties for RNA synthesis were studied in the poly(dAT)-dependent reaction of Escherichia coli RNA polymerase. In the...
Polynucleotides. LVII.1 Synthesis and properties of poly (2'-chloro-2'-deoxyinosinic acid) (1979)
Kakiuchi, Nobuko, Fukui, Toshikazu, Ikehara, Morio
Poly(2′-chloro-2′-deoxyinosinic acid) [poly (Icl)] was synthesized from Icl 5′ -DP by polymerization with polynudleotide phosphorylase. UV absorption properties of poly (Icl) are very similar...
Synthesis of E.coli tRNAfMet fragments and their joining with RNA ligase (1978)
Ohtsuka, Eiko, Tanaka, Toshiki, Miyake, Tetsuo, Nakagawa, Eiko, Antkowiak, Janina, Wakabayashi, Toshiaki, ...
Oligonucleotides corresponding to the E. coli tRNAfMet have been synthesized. A diester approach has been used for the synthesis of 6, 7, 8 and 9. A block condensation of nucleotides with...
Polynucleotides. LVI1. Synthesis and properties of poly(2'-deoxy-2'-fluoroinosinic acid) (1978)
Ikehara, Morio, Kakiuchi, Nobuko, Fukui, Toshikazu
Poly(2′ -deoxy-2′ -fluoroinosinic acid) [poly (If)] was synthesized by polymerization of 2′ -deoxy-2′ -fluoroinosine 5′ -diphosphate catalyzed by Escherichia coli polynucleotide...
Polynucleotides. XLV1) Synthesis and properties of poly(2'-azido-2'-deoxyinosinic acid) (1977)
Fukui, Toshikazu, Kakiuchi, Nubuko, Ikehara, Morio
Poly (2′-azido-2′-deoxyinosinic acid), [poly (Iz)] , was synthesized from 2′-azido-2′-deoxyinosine diphosphate by the action of polynucleotide phosphorylase. Poly (Iz) has UV absorption...
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid) (1977)
Clercq, Erik De, Huang, Guang-Fu, Torrence, Paul F., Fukui, Toshikazu, Kakiuchi, Nobuko, Ikehara, Morio
Poly(2-azaadenylic acid) ((aza2A)n) and poly(2-azainosinic acid ((aza2l)n), two newly synthesized analogues of (A)n and (I)n, in which CH-2 of the purine ring is replaced by a nitrogen atom, have...
Polynucleotides. XLVI. 1 Synthesis and properties of poly (2'-amino-2'-deoxyadenylic acid) (1977)
Ikehara, Morio, Fukui, Toshikazu, Kakiuchi, Nobuko
Poly (2′-amino-2′-deoxyadenylic acid) [poly (Aa)] was prepared from chemically synthesized 2′-amino-2′-deoxy-ADP by the catalysis of polynucleotide phosphorylase. Poly (Aa) showed a similar...
Ikehara, Morio, Fukui, Toshikazu, Kakiuchi, Nobuko
Poly (2′-chloro-2′-deoxyadenylic acid) and poly (2′-bromo- 2′-deoxyadenylic acid) were synthesized from the corresponding diphosphates with the aid of polynucleotide phosphorylase from E....
Ikehara, Morio, Tanaka, Shoji, Fukui, Toshikazu, Ohtsuka, Eiko
2′-O-o-Nitrobenzyluridine, -cytidine and -adenosine were phosphorylated with phosphoryl chloride to the corresponding 5′-phosphates and led to 5′-diphosphates by the method of Moffatt and...
TAKENAKA, Hitoshi, IKEHARA, Morio, TONOMURA, Yuji
The kinetic properties of the hydrolyses of 8-Br ATP and 8-SCH3 ATP by myosin [EC 3.6.1.3] and actomyosin were compared with those of ATP, and the following results were obtained. The Ca-NTPase...
Role of purine N-3 in the biologic activities of poly(A) and poly(I) (1976)
De Clercq, Erik, Torrence, Paul F., Fukui, Toshikazu, Ikehara, Morio
Poly(c3A) (poly 3-deazaadenylic acid) and poly(c3I) (poly 3-deazainosinic acid) differ in biological reactivity from their parent compounds poly(A) and poly(I) and from their 7-deaza counterparts...
Ohtsuka, Eiko, Nishikawa, Satoshi, Sugiura, Masahiro, Ikehara, Morio
T4 RNA ligase was found to join A-A-A-A-A-A and 32pU-U-U-U in the presence of ATP as cofactor. In this reaction the pyrophosphate of *pU-U-U-U and pA was isolated by chromatography on a RPC-5 column,...
Polynucleotides. XL. Synthesis and properties of poly 2'-azido-2'-deoxyadenylic acid (1976)
Ikehara, Morio, Fukui, Toshikazu, Kakiuchi, Nobuko
Poly 2′-azido-2′-deoxyadenylic acid (Poly Az) was synthesized from 2′-azido-2′-deoxyadenosine diphosphate by polynucleotide phosphorylase. Poly (Az) has U.V. absorption properties similar to...
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid) (1975)
De Clercq, Erik, Billiau, Alfons, Hattori, Masao, Ikehara, Morio
Poly (2-methylthioinosinic acid) [poly(ms2I)] was found to markedly inhibit the RNA directed DNA polymerase (reverse transcriptase) activity of murine (Moloney, Rauscher) leukemia virus and murine...
Clercq, Erik De, Hattori, Masao, Ikehara, Morio
Complexes of poly(C) with2 copolymers of inosinic acid containing various amounts of mismatched bases (m2G or ms2 I) have been examined for direct resistance to virus infection, interferon induction...
A dinucleoside monophosphate, 8, 2′-anhydro-8-mercapto-9-β-D-arabinofuranosyladenine phosphoryl-(3′-5′)-inosine (As pI) was synthesized by the condensation of protected 8-mercaptoadenosine...
8,3′-Anhydro-8-mercapto-9-β-D-xylofuranosyladenine (8,3′-S-cycloadenosine) was phosphorylated with cyanoethyl phosphate and DCC to 5′-phosphate. After 6-amino group was benzoylated, the...
Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid (1974)
Ikehara, Morio, Fukui, Toshikazu, Koide, Toshiko, Aba, Junko In
Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has...
Ohtsuka, Eiko, Nakamura, Sojiro, Yoneda, Mariko, Ikehara, Morio
Guanylyl-(3′-5′)-cytidine and guanylyl-(2′-5′)-cytidine were synthesized by condensing 5′-O-monamethoxytritylguanosine and N,2′,3′-O-triacetylcytidine 5′-phosphate using...
Poly(formycin phosphate) and poly (laurusin phosphate) were synthesized by polymerizing formycin and laurusin 5′-diphosphate by means of E. coli polynucleotide phosphorylase. The complex formation...
A dinucleoside ncnophosphate, 6,2′-anhydro-6-oxy-1-β-D–arabinofuranosyluracil-phosphoryl-(3′-5′)-6,2′-anhydro-6-oxy-1-β-D-arabinofuranosyluracil (I) was synthesized by the condensation...
IKEHARA, Morio, FUKUI, Toshikazu, UESUGI, Seiichi
Poly 1-deazaadenylic acid (poly 1-deazaA) and poly 3-deazaadenylic acid (poly 3-deazaA) were synthesized from 1-deaza and 3-deaza ADP by the use of E. coli polynucleotide phosphorylase [EC 2.7.7.8]....
ONISHI, Hirofumi, OHTSUKA, Eiko, IKEHARA, Morio, TONOMURA, Yuji
1. The hydrolysis of 1, N6-ethenoadenosine triphosphate (ϵATP) by myosin [EC 3.6.1.3] and the change in fluorescence of ϵATP induced by H-meromyosin were studied. (a) The amount of...
IKEHARA, Morio, FUKUI, Toshikazu
Aristeromycin 5'-diphosphate (ArDP) and 8, 2'-anhydro-8-mercapto-9-β-D-arabinofuranosyladenine 5'-diphosphate (cycloadenosine DP or ASDP) were synthesized and tested for their properties in the...
Interaction between Synthetic ATP Analogues and Actomyosin Systems. IV (1967)
TONOMURA, YUJI, IMAMURA, KIICHI, IKEHARA, MORIO, UNO, HITOSHI, HARADA, FUMIO
The following compounds were synthesized as analogues of ATP: Tubercidin 5′triphosphate (II), 2′ 3′-O-isopropylidene 6-chloro-(9-β-D-ribofuranosyl) purine 5′triphosphate (III) and 2′...
Polynucleotides. LII1 Synthesis and properties of poly(2′-deoxy-2′-fluoroadenylic acid)
Ikehara, Morio, Fukui, Toshikazu, Kakiuchi, Nobuko
2′-Deoxy-2′-fluoroadenosine was chemically transformed to its 5′-diphosphate and polymerized with polynucleotide phosphorylase to give poly(2′-deoxy-2′-fluoroadenylic acid) [poly(Af)]....
Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid
Ikehara, Morio, Fukui, Toshikazu, Koide, Toshiko, Inaba, Junko
Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has...
Poly(formycin phosphate) and poly(laurusin phosphate) were synthesized by polymerizing formycin and laurusin 5′-diphosphate by means of E. coli polynucleotide phosphorylase. The complex formation...
8,3′-Anhydro-8-mercapto-9-β-D-xylofuranosyladenine (8,3′-s-cycloadenosine) was phosphorylated with cyanoethyl phosphate and DCC to 5′-phosphate. After 6-amino group was benzoylated, the...
A dinucleoside monophosphate, 6,2′-anhydro-6-oxy-1-β-D-arabinofuranosyluracil-phosphoryl- (3′-5′)-6,2′-anhydro-6-oxy-1-β-D-arabinofuranosyluracil (I) was synthesized by the condensation...
Hakoshima, Toshio, Fukui, Toshikazu, Ikehara, Morio, Tomita, Ken-ichi
X-ray fiber diffraction studies of duplexes formed by 2-substituted poly(A) and poly(U) provide evidence for the existence of a double helical structure of poly(A)·poly(U) held together by...
Polynucleotides. LII1 Synthesis and properties of poly(2′-deoxy-2′-fluoroadenylic acid)
Ikehara, Morio, Fukui, Toshikazu, Kakiuchi, Nobuko
2′-Deoxy-2′-fluoroadenosine was chemically transformed to its 5′-diphosphate and polymerized with polynucleotide phosphorylase to give poly(2′-deoxy-2′-fluoroadenylic acid) [poly(Af)]....
Polynucleotides. XXII(1). Synthesis and properties of poly 7-deazainosinic acid
Ikehara, Morio, Fukui, Toshikazu, Koide, Toshiko, Inaba, Junko
Poly 7-deazainosinic acid has been prepared by the deamination and phosphorylation of tubercidin and the nucleoside diphosphate was polymerised using polynucleotide phosphorylase. The polymer has...
Poly(formycin phosphate) and poly(laurusin phosphate) were synthesized by polymerizing formycin and laurusin 5′-diphosphate by means of E. coli polynucleotide phosphorylase. The complex formation...
8,3′-Anhydro-8-mercapto-9-β-D-xylofuranosyladenine (8,3′-s-cycloadenosine) was phosphorylated with cyanoethyl phosphate and DCC to 5′-phosphate. After 6-amino group was benzoylated, the...
A dinucleoside monophosphate, 6,2′-anhydro-6-oxy-1-β-D-arabinofuranosyluracil-phosphoryl- (3′-5′)-6,2′-anhydro-6-oxy-1-β-D-arabinofuranosyluracil (I) was synthesized by the condensation...
Hakoshima, Toshio, Fukui, Toshikazu, Ikehara, Morio, Tomita, Ken-ichi
X-ray fiber diffraction studies of duplexes formed by 2-substituted poly(A) and poly(U) provide evidence for the existence of a double helical structure of poly(A)·poly(U) held together by...