Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia (2009)
Koga, Minori, Ishiguro, Hiroki, Yazaki, Saori, Horiuchi, Yasue, Arai, Makoto, Niizato, Kazuhiro, ...
Chromatin remodeling may play a role in the neurobiology of schizophrenia and the process, therefore, may be considered as a therapeutic target. The SMARCA2 gene encodes BRM in the SWI/SNF...
AP-1 dimers regulate transcription of the p14/p19ARF tumor suppressor gene. (2005)
Ameyar-Zazoua, Maya, Wisniewska, Marta, Bakiri, Latifa, F. Wagner, Erwin, Yaniv, Moshe, B. Weitzman, Jonathan
Gresh, Lionel, Yaniv, Moshe, Rousseau, Guy G, ...
BACKGROUND/AIMS: The portal tracts contain bile ducts associated with branches of the portal vein and of the hepatic artery. Hepatic artery malformations are found in diseases in which fetal biliary...
Muchardt, Christian, Sardet, Claude, Bourachot, Brigitte, Onufryk, Christina, Yaniv, Moshe
In yeast, the SNF/SWI complex is involved in transcriptional activation of several inducible promoters, possiblyby causing a local modification of the chromatin structure. Recently, two human...
Control of HPV 18 DNA replication by cellular and viral transcription factors (1995)
Demeret, Caroline, Le Moal, Mikael, Yaniv, Moshe, Thierry, Françoise
Papillomavirus replication in vivo requires the interaction of the virally encoded proteins E1 and E2 with the origin of replication which is localised in the regulatory region (long control region...
Structure of the gene enconding hepatocyte nuclear factor 1 (HNF1) (1992)
Bach, Ingolf, Pontoglio, Marco, Yaniv, Moshe
Genomlc clones have been isolated that cover the entire gene for the transcription factor HNF1 (hepatocyte nuclear factor 1). This protein governs the expression of many genes, synthesized in the...
Gauthier, Jean-Michel, Dillner, Joakim, Yaniv, Moshe
In order to probe the structure of the transcription factor encoded by the E2 Open Reading Frame of papillomaviruses, we raised polyclonal antibodies against a series of synthetic peptides thai cover...
Two members of an HNF1 homeoprotein family are expressed in human liver (1991)
Bach, Ingolf, Mattei, Marie-Geneviéve, Cereghini, Silvia, Yaniv, Moshe
HNF1 is a transcriptional activator, required for the liver-specific expression of a variety of genes, that binds to DNA as a dimer via the most diverged homeodomain known so far. We were Interested...
A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain (1990)
Chouard, Tanguy, Blumenfeld, Marta, Bach, Ingolf, Vandekerckhove, Joël, Cereghini, Silvia, Yaniv, Moshe
Hepatic Nuclear Factor 1 (HNF1, also referred to as LFB1, HP1 or APF) is a liver-specific transcnption factor required for the expression of many hepatocyte specific genes. We report here the...
Molecular analysis of the interaction between an enhancer binding factor and its DNA target (1986)
The fine contacts of a mouse nuclear factor, called PEB1. with the B enhancer of polyoma virus were analyzed. It protects against DNasel attack a region of about 50 base pairs that can be divided in...
Cossart, Pascale, Katinka, Michaël, Yaniv, Moshe
We have sequenced a DNA fragment containing the Escherichia coli thrA-thrB junction, the complete thrB gene and the thrB-thrC junction. The intergenic sequence thrA and thrB is onlyone base pair. The...
A fraction of the cellular nicking-closing (NC) enzyme cosediments with SV40 chromatin isolated after Triton X-100 treatment of infected cells nuclei. Extraction of viral DNA according to the Hirt...
RB and hbrm cooperate to repress the activation functions of E2F1
Trouche, Didier, Le Chalony, Catherine, Muchardt, Christian, Yaniv, Moshe, Kouzarides, Tony
Forced expression of the retinoblastoma (RB) gene product inhibits the proliferation of cells in culture. A major target of the RB protein is the S-phase-inducing transcription factor E2F1. RB binds...
The human brm protein is cleaved during apoptosis: The role of cathepsin G
Biggs, Joseph R., Yang, Jie, Gullberg, Urban, Muchardt, Christian, Yaniv, Moshe, Kraft, Andrew S.
The human brm (hbrm) protein (homologue of the Drosophila melanogaster brahma and Saccharomyces cervisiae SNF-2 proteins) is part of a polypeptide complex believed to regulate chromatin conformation....
Viollet, Benoît, Yaniv, Moshe, Pontoglio, Marco
The failure to transcribe the phenylalanine hydroxylase (PAH) gene in the liver of hepatocyte nuclear factor 1α (HNF1α)-deficient mice correlated with DNA hypermethylation and the presence of an...
Bourachot, Brigitte, Yaniv, Moshe, Muchardt, Christian
The mammalian SWI-SNF complex is a chromatin-remodelling machinery involved in the modulation of gene expression. Its activity relies on two closely related ATPases known as brm/SNF2α and...
Raney, Anneke K., Eggers, Carrie M., Kline, Eric F., Guidotti, Luca G., Pontoglio, Marco, Yaniv, Moshe, ...
The role of hepatocyte nuclear factor 1α (HNF1α) in the regulation of hepatitis B virus (HBV) transcription and replication in vivo was investigated using a HNF1α-null HBV transgenic mouse model....
Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity
Soutoglou, Evi, Viollet, Benoit, Vaxillaire, Martine, Yaniv, Moshe, Pontoglio, Marco, Talianidis, Iannis
CREB-binding protein (CBP) and CBP-associated factor (P/CAF) are coactivators possessing an intrinsic histone acetyltransferase (HAT) activity. They are positioned at promoter regions via association...
A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
Girardin, Stephen E., Yaniv, Moshe
CrkII, a cellular homolog of v-crk, belongs to a family of adaptor proteins that play a central role in signal transduction cascades. We demonstrate that CrkII interacts directly with c-Jun...
Promoter Specificity and Biological Activity of Tethered AP-1 Dimers
Bakiri, Latifa, Matsuo, Koichi, Wisniewska, Marta, Wagner, Erwin F., Yaniv, Moshe
Activator protein 1 (AP-1) is a group of dimeric transcription factors composed of Jun, Fos, and ATF family proteins. Both gain- and loss-of-function studies have revealed specific roles for...
Bouallaga, Isabelle, Teissier, Sébastien, Yaniv, Moshe, Thierry, Françoise
A strong epithelial specific enhancer drives transcription of the human papillomavirus type 18 (HPV18) oncogenes. Its activity depends on the formation of a higher-order nucleoprotein complex...
JunD protects against chronic kidney disease by regulating paracrine mitogens
Pillebout, Evangéline, Weitzman, Jonathan B., Burtin, Martine, Martino, Carla, Federici, Pierre, Yaniv, Moshe, ...
The AP-1 transcription factor, composed of Jun and Fos proteins, plays a crucial role in the fine tuning of cell proliferation. We showed previously that AP-1 complexes are activated during the...
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter
Agarwal, Sunita K., Novotny, Elizabeth A., Crabtree, Judy S., Weitzman, Jonathan B., Yaniv, Moshe, Burns, A. Lee, ...
Different components of the AP1 transcription factor complex appear to have distinct effects on cell proliferation and transformation. In contrast to other AP1 components, JunD has been shown to...
Growth inhibition by the mammalian SWI–SNF subunit Brm is regulated by acetylation
Bourachot, Brigitte, Yaniv, Moshe, Muchardt, Christian
In mammalian cells, the SWI–SNF chromatin-remodeling complex is a regulator of cell proliferation, and overexpression of the catalytic subunit Brm interferes with cell cycle progression. Here, we...
Bakiri, Latifa, Lallemand, Dominique, Bossy-Wetzel, Ella, Yaniv, Moshe
The transcription factor AP-1, composed of Jun and Fos proteins, is a major target of mitogen-activated signal transduction pathways. However, little is known about AP-1 function in normal cycling...
Bidirectional Transcription and the Regulation of Phage λ Repressor Synthesis
Spiegelman, Willard G., Reichardt, Louis F., Yaniv, Moshe, Heinemann, Stephen F., Kaiser, A. D., Eisen, Harvey
There are two promoters for transcription of gene cI in phage λ, the gene that codes for phage repressor. The promoters, called pre and prm, are located on the distal (pre) and proximal (prm) sides...
A transcriptional network in polycystic kidney disease
Gresh, Lionel, Fischer, Evelyne, Reimann, Andreas, Tanguy, Myriam, Garbay, Serge, Shao, Xinli, ...
Mutations in cystic kidney disease genes represent a major genetic cause of end-stage renal disease. However, the molecular cascades controlling the expression of these genes are still poorly...
Chromatin-Like Structures in Polyoma Virus and Simian Virus 40 Lytic Cycle
Cremisi, Chantal, Pignatti, Pier Franco, Croissant, Odile, Yaniv, Moshe
Nucleoprotein complexes containing viral DNA and cellular histones were extracted from nuclei of permissive cells infected with polyoma virus or simian virus 40 (SV40) and examined by electron...
HNF1α controls renal glucose reabsorption in mouse and man
Pontoglio, Marco, Prié, Dominique, Cheret, Claire, Doyen, Antonia, Leroy, Christine, Froguel, Philippe, ...
Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1 α (HNF1α) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine,...
Bouallaga, Isabelle, Massicard, Séverine, Yaniv, Moshe, Thierry, Françoise
Recent studies have reported new mechanisms that mediate the transcriptional synergy of strong tissue-specific enhancers, involving the cooperative assembly of higher-order nucleoprotein complexes...
Klochendler-Yeivin, Agnes, Fiette, Laurence, Barra, Jaqueline, Muchardt, Christian, Babinet, Charles, Yaniv, Moshe
The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Anderson, Aimee L., Banks, Krista E., Pontoglio, Marco, Yaniv, Moshe, McLachlan, Alan
Treatment with alpha interferon is a standard therapy for patients with chronic hepatitis B virus (HBV) infections. This treatment can reduce virus load and ameliorate disease symptoms. However, in...
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
Gresh, Lionel, Bourachot, Brigitte, Reimann, Andreas, Guigas, Bruno, Fiette, Laurence, Garbay, Serge, ...
Regulation of gene expression underlies cell differentiation and organogenesis. Both transcription factors and chromatin modifiers are crucial for this process. To study the role of the ATP-dependent...
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3
Mateescu, Bogdan, England, Patrick, Halgand, Frederic, Yaniv, Moshe, Muchardt, Christian
Histone H3 lysine 9 methylation is associated with long-term transcriptional repression through recruitment of heterochromatin protein 1 (HP1) proteins. These proteins are believed to promote the...
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
Muchardt, Christian, Guillemé, Marie, Seeler, Jacob-S., Trouche, Didier, Dejean, Anne, Yaniv, Moshe
In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K9-methylated H3 histones are distributed...
Klochendler-Yeivin, Agnes, Picarsky, Eli, Yaniv, Moshe
The gene encoding the SNF5/Ini1 core subunit of the SWI/SNF chromatin remodeling complex is a tumor suppressor in humans and mice, with an essential role in early embryonic development. To...
RB and hbrm cooperate to repress the activation functions of E2F1
Trouche, Didier, Le Chalony, Catherine, Muchardt, Christian, Yaniv, Moshe, Kouzarides, Tony
Forced expression of the retinoblastoma (RB) gene product inhibits the proliferation of cells in culture. A major target of the RB protein is the S-phase-inducing transcription factor E2F1. RB binds...
The human brm protein is cleaved during apoptosis: The role of cathepsin G
Biggs, Joseph R., Yang, Jie, Gullberg, Urban, Muchardt, Christian, Yaniv, Moshe, Kraft, Andrew S.
The human brm (hbrm) protein (homologue of the Drosophila melanogaster brahma and Saccharomyces cervisiae SNF-2 proteins) is part of a polypeptide complex believed to regulate chromatin conformation....
Viollet, Benoît, Yaniv, Moshe, Pontoglio, Marco
The failure to transcribe the phenylalanine hydroxylase (PAH) gene in the liver of hepatocyte nuclear factor 1α (HNF1α)-deficient mice correlated with DNA hypermethylation and the presence of an...
Bourachot, Brigitte, Yaniv, Moshe, Muchardt, Christian
The mammalian SWI-SNF complex is a chromatin-remodelling machinery involved in the modulation of gene expression. Its activity relies on two closely related ATPases known as brm/SNF2α and...
Raney, Anneke K., Eggers, Carrie M., Kline, Eric F., Guidotti, Luca G., Pontoglio, Marco, Yaniv, Moshe, ...
The role of hepatocyte nuclear factor 1α (HNF1α) in the regulation of hepatitis B virus (HBV) transcription and replication in vivo was investigated using a HNF1α-null HBV transgenic mouse model....
Transcription factor-dependent regulation of CBP and P/CAF histone acetyltransferase activity
Soutoglou, Evi, Viollet, Benoit, Vaxillaire, Martine, Yaniv, Moshe, Pontoglio, Marco, Talianidis, Iannis
CREB-binding protein (CBP) and CBP-associated factor (P/CAF) are coactivators possessing an intrinsic histone acetyltransferase (HAT) activity. They are positioned at promoter regions via association...
A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation
Girardin, Stephen E., Yaniv, Moshe
CrkII, a cellular homolog of v-crk, belongs to a family of adaptor proteins that play a central role in signal transduction cascades. We demonstrate that CrkII interacts directly with c-Jun...
Promoter Specificity and Biological Activity of Tethered AP-1 Dimers
Bakiri, Latifa, Matsuo, Koichi, Wisniewska, Marta, Wagner, Erwin F., Yaniv, Moshe
Activator protein 1 (AP-1) is a group of dimeric transcription factors composed of Jun, Fos, and ATF family proteins. Both gain- and loss-of-function studies have revealed specific roles for...
Bouallaga, Isabelle, Teissier, Sébastien, Yaniv, Moshe, Thierry, Françoise
A strong epithelial specific enhancer drives transcription of the human papillomavirus type 18 (HPV18) oncogenes. Its activity depends on the formation of a higher-order nucleoprotein complex...
JunD protects against chronic kidney disease by regulating paracrine mitogens
Pillebout, Evangéline, Weitzman, Jonathan B., Burtin, Martine, Martino, Carla, Federici, Pierre, Yaniv, Moshe, ...
The AP-1 transcription factor, composed of Jun and Fos proteins, plays a crucial role in the fine tuning of cell proliferation. We showed previously that AP-1 complexes are activated during the...
Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter
Agarwal, Sunita K., Novotny, Elizabeth A., Crabtree, Judy S., Weitzman, Jonathan B., Yaniv, Moshe, Burns, A. Lee, ...
Different components of the AP1 transcription factor complex appear to have distinct effects on cell proliferation and transformation. In contrast to other AP1 components, JunD has been shown to...
Growth inhibition by the mammalian SWI–SNF subunit Brm is regulated by acetylation
Bourachot, Brigitte, Yaniv, Moshe, Muchardt, Christian
In mammalian cells, the SWI–SNF chromatin-remodeling complex is a regulator of cell proliferation, and overexpression of the catalytic subunit Brm interferes with cell cycle progression. Here, we...
Bakiri, Latifa, Lallemand, Dominique, Bossy-Wetzel, Ella, Yaniv, Moshe
The transcription factor AP-1, composed of Jun and Fos proteins, is a major target of mitogen-activated signal transduction pathways. However, little is known about AP-1 function in normal cycling...
Bidirectional Transcription and the Regulation of Phage λ Repressor Synthesis
Spiegelman, Willard G., Reichardt, Louis F., Yaniv, Moshe, Heinemann, Stephen F., Kaiser, A. D., Eisen, Harvey
There are two promoters for transcription of gene cI in phage λ, the gene that codes for phage repressor. The promoters, called pre and prm, are located on the distal (pre) and proximal (prm) sides...
A transcriptional network in polycystic kidney disease
Gresh, Lionel, Fischer, Evelyne, Reimann, Andreas, Tanguy, Myriam, Garbay, Serge, Shao, Xinli, ...
Mutations in cystic kidney disease genes represent a major genetic cause of end-stage renal disease. However, the molecular cascades controlling the expression of these genes are still poorly...
Chromatin-Like Structures in Polyoma Virus and Simian Virus 40 Lytic Cycle
Cremisi, Chantal, Pignatti, Pier Franco, Croissant, Odile, Yaniv, Moshe
Nucleoprotein complexes containing viral DNA and cellular histones were extracted from nuclei of permissive cells infected with polyoma virus or simian virus 40 (SV40) and examined by electron...
HNF1α controls renal glucose reabsorption in mouse and man
Pontoglio, Marco, Prié, Dominique, Cheret, Claire, Doyen, Antonia, Leroy, Christine, Froguel, Philippe, ...
Recently it has been shown that dominant mutations in the human hepatocyte nuclear factor 1 α (HNF1α) gene, encoding for a homeoprotein that is expressed in liver, kidney, pancreas and intestine,...
Bouallaga, Isabelle, Massicard, Séverine, Yaniv, Moshe, Thierry, Françoise
Recent studies have reported new mechanisms that mediate the transcriptional synergy of strong tissue-specific enhancers, involving the cooperative assembly of higher-order nucleoprotein complexes...
Klochendler-Yeivin, Agnes, Fiette, Laurence, Barra, Jaqueline, Muchardt, Christian, Babinet, Charles, Yaniv, Moshe
The assembly of eukaryotic DNA into nucleosomes and derived higher order structures constitutes a barrier for transcription, replication and repair. A number of chromatin remodeling complexes, as...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Anderson, Aimee L., Banks, Krista E., Pontoglio, Marco, Yaniv, Moshe, McLachlan, Alan
Treatment with alpha interferon is a standard therapy for patients with chronic hepatitis B virus (HBV) infections. This treatment can reduce virus load and ameliorate disease symptoms. However, in...
The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
Gresh, Lionel, Bourachot, Brigitte, Reimann, Andreas, Guigas, Bruno, Fiette, Laurence, Garbay, Serge, ...
Regulation of gene expression underlies cell differentiation and organogenesis. Both transcription factors and chromatin modifiers are crucial for this process. To study the role of the ATP-dependent...
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3
Mateescu, Bogdan, England, Patrick, Halgand, Frederic, Yaniv, Moshe, Muchardt, Christian
Histone H3 lysine 9 methylation is associated with long-term transcriptional repression through recruitment of heterochromatin protein 1 (HP1) proteins. These proteins are believed to promote the...
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
Muchardt, Christian, Guillemé, Marie, Seeler, Jacob-S., Trouche, Didier, Dejean, Anne, Yaniv, Moshe
In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K9-methylated H3 histones are distributed...
Klochendler-Yeivin, Agnes, Picarsky, Eli, Yaniv, Moshe
The gene encoding the SNF5/Ini1 core subunit of the SWI/SNF chromatin remodeling complex is a tumor suppressor in humans and mice, with an essential role in early embryonic development. To...
Casalino, Laura, Bakiri, Latifa, Talotta, Francesco, Weitzman, Jonathan B, Fusco, Alfredo, Yaniv, Moshe, ...
Fra-1 is frequently overexpressed in epithelial cancers and implicated in invasiveness. We previously showed that Fra-1 plays crucial roles in RAS transformation in rat thyroid cells and mouse...
Hepatocyte Nuclear Factor 1α Controls the Expression of Terminal Complement Genes
Pontoglio, Marco, Pausa, Mario, Doyen, Antonia, Viollet, Benoit, Yaniv, Moshe, Tedesco, Francesco
The terminal components of the complement system contribute to host defense by forming the multiprotein membrane attack complex (MAC) which is responsible for cell lysis and several noncytotoxic...
Reyes, Jose C., Muchardt, Christian, Yaniv, Moshe
Biochemical and genetic evidence suggest that the SWI/SNF complex is involved in the remodeling of chromatin during gene activation. We have used antibodies specific against three human subunits of...
Yaniv, Moshe, Blumberg, Nehemia
Discoid lateral meniscus is an intra-articular knee disorder typically presented in the young population and during adolescence. Different types of meniscal disorders and varied forms of presentation...
Bourgo, Ryan J., Siddiqui, Hasan, Fox, Sejal, Solomon, David, Sansam, Courtney G., Yaniv, Moshe, ...
Switch (SWI)/sucrose nonfermentable (SNF) is an evolutionarily conserved complex with ATPase function, capable of regulating nucleosome position to alter transcriptional programs within the cell. It...