Mutsunori Shirai

Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus (2009)

Azuma, Yoshinao, Hosoyama, Akira, Matsutani, Minenosuke, Furuya, Naoko, Horikawa, Hiroshi, Harada, Takeshi, ...

Acetobacter species have been used for brewing traditional vinegar and are known to have genetic instability. To clarify the mutability, Acetobacter pasteurianus NBRC 3283, which forms a...

Genome-wide Analysis of Chlamydophila pneumoniae Gene Expression at the Late Stage of Infection (2008)

Miura, Koshiro, Toh, Hidehiro, Hirakawa, Hideki, Sugii, Manabu, Murata, Masayuki, Nakai, Kenta, ...

Chlamydophila pneumoniae, an obligate intracellular eubacterium, changes its form from a vegetative reticulate body into an infectious elementary body during the late stage of its infection cycle....

Genome Sequence of the Cat Pathogen, Chlamydophila felis (2006)

Azuma, Yoshinao, Hirakawa, Hideki, Yamashita, Atsushi, Cai, Yan, Rahman, Mohd Akhlakur, Suzuki, Harumi, ...

Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the...

Genome Sequence of the Cat Pathogen, Chlamydophila felis (2006)

Azuma, Yoshinao, Hirakawa, Hideki, Yamashita, Atsushi, Cai, Yan, Rahman, Mohd Akhlakur, Suzuki, Harumi, ...

Chlamydophila felis (Chlamydia psittaci feline pneumonitis agent) is a worldwide spread pathogen for pneumonia and conjunctivitis in cats. Herein, we determined the entire genomic DNA sequence of the...

Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite Chlamydia (2005)

Rahman, Mohd. Akhlakur, Azuma, Yoshinao, Fukunaga, Hajime, Murakami, Tomoyuki, Sugi, Kazurou, Fukushi, Hideto, ...

Objectives: Chlamydiae are obligate intracellular bacteria, causing a variety of diseases, i.e. pneumonia, sexually transmitted disease, conjunctivitis and zoonosis. Tryptophan depletion by...

Serotonin and melatonin, neurohormones for homeostasis, as novel inhibitors of infections by the intracellular parasite chlamydia (2005)

Rahman, Mohd. Akhlakur, Azuma, Yoshinao, Fukunaga, Hajime, Murakami, Tomoyuki, Sugi, Kazurou, Fukushi, Hideto, ...

Objectives: Chlamydiae are obligate intracellular bacteria, causing a variety of diseases, i.e. pneumonia, sexually transmitted disease, conjunctivitis and zoonosis. Tryptophan depletion by...

In silico Inference of Inclusion Membrane Protein Family in Obligate Intracellular Parasites Chlamydiae (2003)

Toh, Hidehiro, Miura, Koshiro, Shirai, Mutsunori, Hattori, Masahira

Chlamydiae are obligate intracellular pathogens that proliferate only inside a vacuole, called an inclusion. Chlamydial Inc proteins are known to be a major component of the inclusion membrane, but...

A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori (2002)

Okamoto, Takeshi, Yoshiyama, Hironori, Nakazawa, Teruko, Park, In-Dal, Chang, Myung-Woong, Yanai, Hideo, ...

Reports on the isolation of amoxicillin-resistant Helicobacter pylori are increasing worldwide, which may cause serious problems in eradication therapy. To elucidate the mechanism of amoxicillin...

A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori (2002)

Okamoto, Takeshi, Yoshiyama, Hironori, Nakazawa, Teruko, Park, In-Dal, Chang, Myung-Woong, Yanai, Hideo, ...

Reports on the isolation of amoxicillin-resistant Helicobacter pylori are increasing worldwide, which may cause serious problems in eradication therapy. To elucidate the mechanism of amoxicillin...

A change in PBP1 is involved in amoxicillin resistance of clinical isolates of Helicobacter pylori (2002)

Okamoto, Takeshi, Yoshiyama, Hironori, Nakazawa, Teruko, Park, In-Dal, Chang, Myung-Woong, Yanai, Hideo, ...

Reports on the isolation of amoxicillin-resistant Helicobacter pylori are increasing worldwide, which may cause serious problems in eradication therapy. To elucidate the mechanism of amoxicillin...

Differences in genotypes of Helicobacter pylori from different human populations. (2000)

Kersulyte, Dangeruta, Mukhopadhyay, Asish K., Velapati O, Billie, Su, WanWen, Pan, ZhiJun, Garcia, Claudia, ...

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric...

Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA (2000)

Shirai, Mutsunori, Hirakawa, Hideki, Kimoto, Mitsuaki, Tabuchi, Mitsuaki, Kishi, Fumio, Ouchi, Kazunobu, ...

Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C.pneumoniae infection and atherosclerosis. We determined...

Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model

Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...

DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...

In Vitro Anti-Helicobacter pylori Activities of New Rifamycin Derivatives, KRM-1648 and KRM-1657

Akada, Junko K., Shirai, Mutsunori, Fujii, Kenji, Okita, Kiwamu, Nakazawa, Teruko

The new rifamycin derivatives KRM-1657 and KRM-1648 were evaluated for their in vitro antimicrobial activities against 44 strains of Helicobacter pylori. Although the drugs were not very active...

Differences in Genotypes of Helicobacter pylori from Different Human Populations

Kersulyte, Dangeruta, Mukhopadhyay, Asish K., Velapatiño, Billie, Su, WanWen, Pan, ZhiJun, Garcia, Claudia, ...

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric...

Lymphotoxin Inhibits Chlamydia pneumoniae Growth in HEp-2 Cells

Matsushima, Hiroshi, Shirai, Mutsunori, Ouchi, Kazunobu, Yamashita, Kenji, Kakutani, Tetsu, Furukawa, Susumu, ...

Cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-α) inhibit the intracellular replication of Chlamydia pneumoniae or Chlamydia trachomatis. In this study, we found that...

Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA

Shirai, Mutsunori, Hirakawa, Hideki, Kimoto, Mitsuaki, Tabuchi, Mitsuaki, Kishi, Fumio, Ouchi, Kazunobu, ...

Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C.pneumoniae infection and atherosclerosis. We determined...

Nucleotide Sequence and Characterization of cdrA, a Cell Division-Related Gene of Helicobacter pylori

Takeuchi, Hiroaki, Shirai, Mutsunori, Akada, Junko K., Tsuda, Masataka, Nakazawa, Teruko

We identified cell division-related gene cdrA in Helicobacter pylori HPK5. The putative gene product, CdrA, is a 367-amino-acid polypeptide that exhibited a high level of homology to conserved...

Efficient Class II Major Histocompatibility Complex Presentation of Endogenously Synthesized Hepatitis C Virus Core Protein by Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Lines to CD4+ T Cells

Chen, Ming, Shirai, Mutsunori, Liu, Zijuan, Arichi, Tatsumi, Takahashi, Hidemi, Nishioka, Mikio

The induction of an efficient CD4+ T-cell response against hepatitis C virus (HCV) is critical for control of the chronicity of HCV infection. The ability of HCV structural protein endogenously...

Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model

Arichi, Tatsumi, Saito, Takafumi, Major, Marian E., Belyakov, Igor M., Shirai, Mutsunori, Engelhard, Victor H., ...

DNA vaccines express antigens intracellularly and effectively induce cellular immune responses. Because only chimpanzees can be used to model human hepatitis C virus (HCV) infections, we developed a...

In Vitro Anti-Helicobacter pylori Activities of New Rifamycin Derivatives, KRM-1648 and KRM-1657

Akada, Junko K., Shirai, Mutsunori, Fujii, Kenji, Okita, Kiwamu, Nakazawa, Teruko

The new rifamycin derivatives KRM-1657 and KRM-1648 were evaluated for their in vitro antimicrobial activities against 44 strains of Helicobacter pylori. Although the drugs were not very active...

Differences in Genotypes of Helicobacter pylori from Different Human Populations

Kersulyte, Dangeruta, Mukhopadhyay, Asish K., Velapatiño, Billie, Su, WanWen, Pan, ZhiJun, Garcia, Claudia, ...

DNA motifs at several informative loci in more than 500 strains of Helicobacter pylori from five continents were studied by PCR and sequencing to gain insights into the evolution of this gastric...

Lymphotoxin Inhibits Chlamydia pneumoniae Growth in HEp-2 Cells

Matsushima, Hiroshi, Shirai, Mutsunori, Ouchi, Kazunobu, Yamashita, Kenji, Kakutani, Tetsu, Furukawa, Susumu, ...

Cytokines such as gamma interferon and tumor necrosis factor alpha (TNF-α) inhibit the intracellular replication of Chlamydia pneumoniae or Chlamydia trachomatis. In this study, we found that...

Comparison of whole genome sequences of Chlamydia pneumoniae J138 from Japan and CWL029 from USA

Shirai, Mutsunori, Hirakawa, Hideki, Kimoto, Mitsuaki, Tabuchi, Mitsuaki, Kishi, Fumio, Ouchi, Kazunobu, ...

Chlamydia pneumoniae is a widespread pathogen of humans causing pneumonia and bronchitis. There are many reports of an association between C.pneumoniae infection and atherosclerosis. We determined...

Nucleotide Sequence and Characterization of cdrA, a Cell Division-Related Gene of Helicobacter pylori

Takeuchi, Hiroaki, Shirai, Mutsunori, Akada, Junko K., Tsuda, Masataka, Nakazawa, Teruko

We identified cell division-related gene cdrA in Helicobacter pylori HPK5. The putative gene product, CdrA, is a 367-amino-acid polypeptide that exhibited a high level of homology to conserved...

Efficient Class II Major Histocompatibility Complex Presentation of Endogenously Synthesized Hepatitis C Virus Core Protein by Epstein-Barr Virus-Transformed B-Lymphoblastoid Cell Lines to CD4+ T Cells

Chen, Ming, Shirai, Mutsunori, Liu, Zijuan, Arichi, Tatsumi, Takahashi, Hidemi, Nishioka, Mikio

The induction of an efficient CD4+ T-cell response against hepatitis C virus (HCV) is critical for control of the chronicity of HCV infection. The ability of HCV structural protein endogenously...

Genome-wide Analysis of Chlamydophila pneumoniae Gene Expression at the Late Stage of Infection

Miura, Koshiro, Toh, Hidehiro, Hirakawa, Hideki, Sugii, Manabu, Murata, Masayuki, Nakai, Kenta, ...

Chlamydophila pneumoniae, an obligate intracellular eubacterium, changes its form from a vegetative reticulate body into an infectious elementary body during the late stage of its infection cycle....

Whole-genome analyses reveal genetic instability of Acetobacter pasteurianus

Azuma, Yoshinao, Hosoyama, Akira, Matsutani, Minenosuke, Furuya, Naoko, Horikawa, Hiroshi, Harada, Takeshi, ...

Acetobacter species have been used for brewing traditional vinegar and are known to have genetic instability. To clarify the mutability, Acetobacter pasteurianus NBRC 3283, which forms a...