Rose, C., Ytrebø, L.M., Davies, N.A., Sen, S., Nedredal, G.I., Belanger, M., ...
We previously demonstrated in pigs with acute liver failure (ALF) that albumin dialysis using the molecular adsorbents recirculating system (MARS) attenuated a rise in intracranial pressure (ICP)....
Mookerjee, R.P., Stadlbauer, V., Lidder, S., Wright, G.A.K., Hodges, S.J., Davies, N.A., ...
Mortality in patients with alcoholic hepatitis (AH) remains high, and although corticosteroids are widely used for treatment, the results vary considerably. In AH, neutrophils are primed and...
Endotoxemia produces coma and brain swelling in bile duct ligated rats (2007)
Wright, G., Davies, N.A., Shawcross, D.L., Hodges, S.J., Zwingmann, C., Brooks, H.F., ...
This study explores the hypothesis that the inflammatory response induced by administration of lipopolysaccharide (LPS) exacerbates brain edema in cirrhotic rats; and if so whether this is associated...
Mookerjee, R.P., Wiesenthal, A., Icking, A., Hodges, S.J., Davies, N.A., Schilling, K., ...
Background & Aims: Increased intrahepatic resistance in cirrhosis is associated with reduced endothelial NO synthase (eNOS) activity and exacerbated by superimposed inflammation. NOSTRIN induces...
Mookerjee, R.P., Dalton, R.N., Davies, N.A., Hodges, S.J., Turner, C., Williams, R., ...
Acute liver failure (ALF) is characterized by rapid progressive organ failure and poor outcome. The pathophysiology of multiorgan dysfunction in ALF remains unclear but increased systemic...
Mookerjee, R.P., Malaki, M., Davies, N.A., Hodges, S.J., Dalton, R.N., Turner, C., ...
Previous studies suggest reduced hepatic endothelial nitric oxide synthase activity contributes to increased intrahepatic resistance. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide...
Interorgan ammonia, glutamate, and glutamine trafficking in pigs with acute liver failure (2006)
Ytrebø, L.M., Sen, S., Rose, C., Ten Have, A.M., Davies, N.A., Hodges, S., ...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data about how the individual organs handle ammonia limits our ability to develop novel therapeutic...
Davies, N.A., Hodges, S.J., Pitsillides, A.A., Mookerjee, R.P., Jalan, R., Mehdizadeh, S.
The production of nitric oxide (NO) in liver disease and its role in vascular control has been a subject of much interest in recent years. However, the activity of guanylate cyclase (GC), the enzyme...
Albumin dialysis reduces portal pressure acutely in patients with severe alcoholic hepatitis (2005)
Sen, S., Mookerjee, R.P., Cheshire, L.M., Davies, N.A., Williams, R., Jalan, R.
Background/Aims In patients with alcoholic hepatitis (AH), inflammation contributes to the severity of portal hypertension. This study evaluates the acute effects of albumin dialysis, using the...
Nitrosyl heme production compared in endotoxemic and hemorrhagic shock (2005)
Davies, N.A., Brealey, D.A., Stidwill, R., Singer, M., Svistunenko, D.A., Cooper, C.E.
We compared nitric oxide production and nitrosyl hemoglobin steady state concentrations during the early phases of endotoxemic and hemorrhagic shock of equivalent severity. Sprague–Dawley rats were...
Shawcross, D.L., Davies, N.A., Mookerjee, R.P., Hayes, P.C., Williams, R., Lee, A., ...
There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom...
Shawcross, D.L., Davies, N.A., Mookerjee, R.P., Hayes, P.C., Williams, R., Lee, A., ...
There is increasing evidence that terlipressin is useful in patients with cirrhosis and hepatorenal syndrome, but there are no data of its use in patients with acute liver failure (ALF) in whom...
Shawcross, D.L., Davies, N.A., Williams, R., Jalan, R.
Background: Studies in acute liver failure show correlation between evidence of a systemic inflammatory response syndrome (SIRS) and progression of Hepatic Encephalopathy (HE). We tested the...
Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis (2003)
Tilg, H., Jalan, R., Kaser, A., Davies, N.A., Offner, F.A., Hodges, S.J., ...
Background/Aims: Severe alcoholic hepatitis (AH) is associated with high mortality. Tumor necrosis factor-alpha (TNF) has been demonstrated to play an important role in its pathophysiology. Methods:...
Association between mitochondrial dysfunction and severity and outcome of septic shock (2002)
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., ...
Summary: Background: Sepsis-induced multiple organ failure is the major cause of mortality and morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is...
Association between mitochondrial dysfunction and severity and outcome of septic shock (2002)
Brealey, D., Brand, M., Hargreaves, I., Heales, S., Land, J., Smolenski, R., ...
Background: Sepsis-induced multiple organ failure is the major cause of mortality and morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is caused remain...