Many investisators have recognized that sophisticated mechanical translation or other computational linguistic systems will require language learning capabilities, both in the ability to discover and...
MSIM 602: Computer Science Concepts for Modeling and Simulation (2008)
Course Syllabus, N. Dale, D. T. Joyce, C. Weems
MSIM 602 provides an introduction to computer science concepts essential to implementing and understanding the performance of simulation software. The course emphasis is on the implementation and use...
Dale, A. G., Dale, N., Pendergraft, E. D.
Two key problems, both of which must be solved as a part continuing progress toward full use of the computer are discussed: automatic classification techniques, and how to use them as a basis for...
ATP is a mediator of chemosensory transduction in the central nervous system (2005)
Gourine, A.V., Llaudet, E., Dale, N., Spyer, K.M.
Extracellular signalling by the purine nucleotide ATP has long been associated with sensory function1, 2, 3, 4, 5, 6, 7, 8. In the periphery, ATP mediates nociception3, 4, 5, mechanosensitivity3, 6,...
Pearson, R.A., Dale, N., Llaudet, E., Mobbs, P.
The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+...
Pearson, R.A., Dale, N., Llaudet, E., Mobbs, P.
The retinal pigment epithelium (RPE) plays an essential role in the normal development of the underlying neural retina, but the mechanisms by which this regulation occurs are largely unknown. Ca2+...
Begg, M., Dale, N., Llaudet, E., Molleman, A., Parsons, M.
Original article can be found at: http://www.nature.com/bjp/index.html Copyright British Pharmacological Society and Nature Publishing Group. DOI: 10.1038/sj.bjp.0704985 [Full text of this article is...
Rates of Axial Transport of 11C and 14C in Characean Cells: Faster than Visible Streaming? (1983)
DALE, N., LUNN, G., FENSOM, D. S., WILLIAMS, E. J.
Movements of 11C and 14C in N. translucens occur at rates two to five times greater than those of visually observed streaming. Like cytoplasmic streaming, longitudinal tracer movement is stopped...
L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons.
Although modulation of synaptic transmission between Aplysia mechanosensory and motor neurons has been an important model for processes thought to underlie simple forms of learning and memory, the...
Braha, O, Dale, N, Hochner, B, Klein, M, Abrams, T W, Kandel, E R
Presynaptic facilitation of transmitter release contributes to behavioral sensitization and dishabituation, two simple forms of learning in Aplysia. This enhancement of transmitter release can be...
1. The actions of GABAB receptors in the generation of the neuronal pattern underlying swimming in the Xenopus embryo have been investigated using the agonist baclofen. 2. Baclofen (10-100 microM)...
1. Acutely isolated Xenopus spinal neurons possess a slowly activating Ca(2+)-dependent outward current which was revealed either by removal of external Ca2+ or by the addition of the Ca2+ channel...
Kinetic characterization of the voltage-gated currents possessed by Xenopus embryo spinal neurons.
1. Using the whole-cell patch clamp technique, the voltage-gated currents of neurons acutely isolated from the Xenopus embryo spinal cord were studied. 2. The spinal neurons possessed a very fast Na+...
Experimentally derived model for the locomotor pattern generator in the Xenopus embryo.
1. Simulations of Xenopus embryo spinal neurons were endowed with Hodgkin-Huxley-style models of voltage-dependent Na+, Ca2+, slow K+ and fast K+ currents together with a Na(+)-dependent K+ current....
A large, sustained Na(+)- and voltage-dependent K+ current in spinal neurons of the frog embryo.
1. Neurons from the Xenopus embryo spinal cord were dissociated and conventional patch clamp techniques were used to record the whole-cell currents in the presence of tetrodotoxin (TTX). 2. The...
1. The monoamine transmitter 5-hydroxytryptamine (5-HT) and the peptide Phe-Met-Arg-Phe-amide (FMRFa), which appear to contribute to presynaptic facilitation and inhibition of the sensorimotor...
The neuronal basis of the excitation received by motoneurones during swimming in curarized Xenopus embryos has been investigated further. Extracellular stimulation of axons in the fibre tracts of the...
Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.
The mechanism of reciprocal inhibition between antagonistic motor centres during swimming in the paralysed Xenopus embryo has been investigated further. Paired intracellular recordings have been made...
Bath application of N-methyl-D-aspartate (NMDA), kainate or quisqualate to Xenopus embryos depolarized spinal cord motoneurones and reduced their input resistance in both normal salines and salines...
Factors influencing general practitioner referrals to a tertiary paediatric neurodisability service.
This study investigated factors influencing general practitioner (GP) referrals to a tertiary paediatric neurodisability service, including the reasons for referral, the children's characteristics,...
L-glutamate may be the fast excitatory transmitter of Aplysia sensory neurons.
Although modulation of synaptic transmission between Aplysia mechanosensory and motor neurons has been an important model for processes thought to underlie simple forms of learning and memory, the...
Braha, O, Dale, N, Hochner, B, Klein, M, Abrams, T W, Kandel, E R
Presynaptic facilitation of transmitter release contributes to behavioral sensitization and dishabituation, two simple forms of learning in Aplysia. This enhancement of transmitter release can be...
1. The actions of GABAB receptors in the generation of the neuronal pattern underlying swimming in the Xenopus embryo have been investigated using the agonist baclofen. 2. Baclofen (10-100 microM)...
1. Acutely isolated Xenopus spinal neurons possess a slowly activating Ca(2+)-dependent outward current which was revealed either by removal of external Ca2+ or by the addition of the Ca2+ channel...
Kinetic characterization of the voltage-gated currents possessed by Xenopus embryo spinal neurons.
1. Using the whole-cell patch clamp technique, the voltage-gated currents of neurons acutely isolated from the Xenopus embryo spinal cord were studied. 2. The spinal neurons possessed a very fast Na+...
Experimentally derived model for the locomotor pattern generator in the Xenopus embryo.
1. Simulations of Xenopus embryo spinal neurons were endowed with Hodgkin-Huxley-style models of voltage-dependent Na+, Ca2+, slow K+ and fast K+ currents together with a Na(+)-dependent K+ current....
A large, sustained Na(+)- and voltage-dependent K+ current in spinal neurons of the frog embryo.
1. Neurons from the Xenopus embryo spinal cord were dissociated and conventional patch clamp techniques were used to record the whole-cell currents in the presence of tetrodotoxin (TTX). 2. The...
1. The monoamine transmitter 5-hydroxytryptamine (5-HT) and the peptide Phe-Met-Arg-Phe-amide (FMRFa), which appear to contribute to presynaptic facilitation and inhibition of the sensorimotor...
The neuronal basis of the excitation received by motoneurones during swimming in curarized Xenopus embryos has been investigated further. Extracellular stimulation of axons in the fibre tracts of the...
Reciprocal inhibitory interneurones in the Xenopus embryo spinal cord.
The mechanism of reciprocal inhibition between antagonistic motor centres during swimming in the paralysed Xenopus embryo has been investigated further. Paired intracellular recordings have been made...
Bath application of N-methyl-D-aspartate (NMDA), kainate or quisqualate to Xenopus embryos depolarized spinal cord motoneurones and reduced their input resistance in both normal salines and salines...
Factors influencing general practitioner referrals to a tertiary paediatric neurodisability service.
This study investigated factors influencing general practitioner (GP) referrals to a tertiary paediatric neurodisability service, including the reasons for referral, the children's characteristics,...
Begg, M, Dale, N, Llaudet, E, Molleman, A, Parsons, M E
Interactions between the cannabinoid system and the adenosine system were investigated in the myenteric plexus-longitudinal muscle (MPLM) of the guinea-pig ileum.Electrically-evoked contractions of...
1. The potassium current in embryo spinal neurones of Xenopus consists of at least two kinetically distinct components with overlapping voltage-dependencies of activation. We investigated whether...
The K+ currents of spinal neurons acutely dissociated from Xenopus larvae were studied and compared with those of neurons dissociated from Xenopus embryos.The density of total outward current in the...
Neurological outcome of patients with ornithine carbamoyltransferase deficiency
Nicolaides, P, Liebsch, D, Dale, N, Leonard, J, Surtees, R
Background: Ornithine carbamoyltransferase (OCT) deficiency is the commonest of the inherited urea cycle disorders.