Non-invasive Monitoring of Glutathione Metabolism and Heterogeneity in Rat Tumor Tissue (2008)
P. E. Thelwall, A. Y. Yemin, N. E. Simpson, T. Schehl, J. M. Macdonald, S. J. Blackb, ...
Glutathione (GSH) is a tri-peptide of glutamate, cysteine and glycine. It is one of the primary antioxidants found in tissue and plays a major role in cancer development and therapy response (1-4)....
Two polymorphisms at the D10S94 locus (1990)
Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E., Goodfellow, P.J.
Three polymorphisms at the D10S85 locus (1990)
Goodfellow, P.J., Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E.
A polymorphic locus, D10S5, at 10q21.1 (1987)
McDermid, H.E., Goodfellow, P.J., Duncan, A.M.V., Brasch, K.R., Simpson, N.E., Souza, C.D., ...
Three RFLPs recognized by an anonymous sequence localized to 21q11.2 [HGM8 D21S72] (1986)
Goodfellow, P. J., Duncan, A. M. V., Simpson, N. E., White, B. N.
A polymorphic locus, D10S5, at 10q21.1.
McDermid, H E, Goodfellow, P J, Duncan, A M, Brasch, K R, Simpson, N E, Souza, C D, ...
Two polymorphisms at the D10S94 locus
Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E., Goodfellow, P.J.
Three polymorphisms at the D10S85 locus
Goodfellow, P.J., Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E.
Goodfellow, P J, Myers, S, Anderson, L L, Brooks-Wilson, A R, Simpson, N E
Combined somatic cell hybrid and linkage studies between D10S94 and five pericentromeric loci (FNRB, D10Z1, MEN2A, RBP3, and D10S15) have localized the new DNA sequence pcl1/A1S-6-c23 at D10S94 to...
Carson, N L, Wu, J S, Jackson, C E, Kidd, K K, Simpson, N E
Two new morphs (F and G) detected by the centromeric alpha satellite probe p alpha 10RP8 and D10Z1 in HinfI digests are linked to the PstI polymorphisms of D10Z1, confirming their chromosome 10...
Farrer, L A, Goodfellow, P J, Lamarche, C M, Franjkovic, I, Myers, S, White, B N, ...
Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were typed for seven DNA markers and one red cell enzyme marker on chromosome 13. Close linkage was...
Linkage studies of Friedreich ataxia by means of blood-group and protein markers
Keats, B. J. B., Ward, L. J., Lu, M., Krieger, S., Wilensky, M. A., Forster-Gibson, C. J., ...
Friedreich ataxia (FA) is an autosomal recessive, neuro-degenerative disorder in which the pathogenetic mechanism remains unidentified despite extensive biochemical studies. Genetic-linkage studies...
Genetic mapping of DNA segments relative to the locus for the fragile-X syndrome at Xq27.3.
Mulligan, L M, Phillips, M A, Forster-Gibson, C J, Beckett, J, Partington, M W, Simpson, N E, ...
We have tested linkage between the locus for the fragile-X [fra(X)] syndrome at Xq27.3 and five polymorphic restriction sites identified by four DNA probes mapping distal to Xq26.1. A maximum...
Linkage analysis of a DNA marker localized to 20p12 and multiple endocrine neoplasia type 2A.
Goodfellow, P J, White, B N, Holden, J J, Duncan, A M, Sears, E V, Wang, H S, ...
A DNA segment D20S5 isolated from a chromosome 19/20 flow-sorted library was shown to identify two restriction fragment length polymorphisms (RFLPs) with MspI and PvuII. The probe was localized by...
Cholinesterase Newfoundland: a new succinylcholine-sensitive variant of cholinesterase at locus 1.
A family from Newfoundland was found to have a new rare variant for plasma cholinesterase (E.C.3.1.1.8) recognized by a high-percentage inhibition by dibucaine (DN), particularly when...
A polymorphic locus, D10S5, at 10q21.1.
McDermid, H E, Goodfellow, P J, Duncan, A M, Brasch, K R, Simpson, N E, Souza, C D, ...
Two polymorphisms at the D10S94 locus
Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E., Goodfellow, P.J.
Three polymorphisms at the D10S85 locus
Goodfellow, P.J., Brooks-Wilson, A.R., Smailus, D., Myers, S., Anderson, L., Simpson, N.E.
Goodfellow, P J, Myers, S, Anderson, L L, Brooks-Wilson, A R, Simpson, N E
Combined somatic cell hybrid and linkage studies between D10S94 and five pericentromeric loci (FNRB, D10Z1, MEN2A, RBP3, and D10S15) have localized the new DNA sequence pcl1/A1S-6-c23 at D10S94 to...
Carson, N L, Wu, J S, Jackson, C E, Kidd, K K, Simpson, N E
Two new morphs (F and G) detected by the centromeric alpha satellite probe p alpha 10RP8 and D10Z1 in HinfI digests are linked to the PstI polymorphisms of D10Z1, confirming their chromosome 10...
Farrer, L A, Goodfellow, P J, Lamarche, C M, Franjkovic, I, Myers, S, White, B N, ...
Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were typed for seven DNA markers and one red cell enzyme marker on chromosome 13. Close linkage was...
Linkage studies of Friedreich ataxia by means of blood-group and protein markers
Keats, B. J. B., Ward, L. J., Lu, M., Krieger, S., Wilensky, M. A., Forster-Gibson, C. J., ...
Friedreich ataxia (FA) is an autosomal recessive, neuro-degenerative disorder in which the pathogenetic mechanism remains unidentified despite extensive biochemical studies. Genetic-linkage studies...
Genetic mapping of DNA segments relative to the locus for the fragile-X syndrome at Xq27.3.
Mulligan, L M, Phillips, M A, Forster-Gibson, C J, Beckett, J, Partington, M W, Simpson, N E, ...
We have tested linkage between the locus for the fragile-X [fra(X)] syndrome at Xq27.3 and five polymorphic restriction sites identified by four DNA probes mapping distal to Xq26.1. A maximum...
Linkage analysis of a DNA marker localized to 20p12 and multiple endocrine neoplasia type 2A.
Goodfellow, P J, White, B N, Holden, J J, Duncan, A M, Sears, E V, Wang, H S, ...
A DNA segment D20S5 isolated from a chromosome 19/20 flow-sorted library was shown to identify two restriction fragment length polymorphisms (RFLPs) with MspI and PvuII. The probe was localized by...
Cholinesterase Newfoundland: a new succinylcholine-sensitive variant of cholinesterase at locus 1.
A family from Newfoundland was found to have a new rare variant for plasma cholinesterase (E.C.3.1.1.8) recognized by a high-percentage inhibition by dibucaine (DN), particularly when...
Multiple endocrine neoplasia, type II: a combined surgical and genetic approach to treatment.
Partington, M W, Ghent, W R, Sears, E V, Simpson, N E
A family with multiple endocrine neoplasia, type II living in southeastern Ontario is described. Twenty individuals are known to have had medullary carcinoma of the thyroid, pheochromocytoma or both,...
Hereditary angioneurotic edema and Charcot-Marie-Tooth disease in the same family.
Fernandez, P. G., Day, J. H., Simpson, N. E., Zachariah, P. K.
In one family two genetic diseases were transmitted as autosomal dominant traits; hereditary angioneurotic edema was inherited from the paternal side and Charcot-Marie Tooth disease from the maternal...
Antenatal diagnosis of neural tube defects in Canada: extension of a collaborative study.
Simpson, N. E., Dallaire, L., Miller, J. R., Siminovitch, L., Miller, J., Hamerton, J. L.
Experience with the diagnosis of neural tube defects from alpha1-fetoprotein (AFP) concentrations in amniotic fluid is reported from a prospective study of five laboratories testing for 13 Canadian...
Prenatal diagnosis of genetic disease in Canada: report of a collaborative study.
Simpson, N. E., Dallaire, L., Miller, J. R., Siminovich, L., Hamerton, J. L., Miller, J., ...
A study of 1223 amniocenteses carried out during 1020 pregnancies in 990 women showed that 2nd-trimester amniocentesis at about 16 weeks' gestation is a safe, accurate and reliable procedure for the...
Dic(21;21) in a Down's syndrome child with an unusual chromosome 9 variant in the mother.
Berg, J M, Gardner, H A, Gardner, R J, Goh, E G, Markovic, V D, Simpson, N E, ...
A child with characteristic clinical features of Down's syndrome and raised red cell SOD-1 activity was found to have, in addition to a single chromosome 21, a reverse dicentric tandem translocation...
The number of gene assignments to human chromosome 20 has increased slowly until recently. Only seven genes and one fragile site were confirmed assignments to chromosome 20 at the Ninth Human Gene...